Mepolizumab uye Reslizumab yeAsinophilic Asthma
Chirwere chechirwere chirwere chisingaperi chisingagumi chinokonzera kusvika 12 muzana yevanhu uye chinonyanya kufanana muUnited States nedzimwe nyika dzemaMadokero. Chirwere chinokonzerwa nezviitiko zvinowanzoitika zvekufema, kukwezva, kupfupika kwemhepo uye chifukidzo chechifuva, zvine zviratidzo zvichibva kune zvinyoro kana kuti zvishoma nezvishoma kusvika zvakanyanya uye kutyisidzira upenyu.
Vanhu vane chirwere chakasimba vanogona kuva nekuderera kukuru muhupenyu hwehupenyu uye vanogona kuve nekuwedzerwa kwekuwedzera kwekuda kwekudiwa kwemukanwa corticosteroids , nzvimbo dzekukurumidza dzekushanyira, uye hospital hospital.
Kune miviri yakasiyana yemishonga inonzi asthma inowanikwa yekudzivirira asthma. Kazhinji idzi dzinosanganisira corticosteroids inhaled , nguva refu inobata bronchodilators, uye leukotriene modifier zvinodhaka, zvakadai sa Singulair . Vanhu vane chirwere chakasimba chemaharahma vanoda kushandiswa kweXolair . Pasinei nemishonga iyi yakasiyana-siyana yemishonga, zvisinei, dzakawanda zve asthmatics dzinoramba dzichingowedzera kuwedzera kunoda kushandiswa kwemuromo kana kuti inorable corticosteroids.
Xolair ndiyo yekutanga yekurapa biologic mishonga yekurapa kwekuenzanisa kusvika kuhutachiona. Icho chinonzi monoclonal antibody chinorwisana neGI . Izvi zvinoreva kuti an antibody yakagadzirwa mu laboratori inorwisana neAgE antibody-"chigadziro" chekugadzirisa zvirwere. Apo inonzi asthmatic ine zvirwere zvinokonzera zvirwere, zvakadai sep pet dander kana guruva mite , uye zviratidzo hazvidzorwi nemishonga yakadai seyakakonzerwa nekarticosteroids, Xolair inogona kushandiswa kuderedza zviratidzo zvechirwere uye kuwedzera kwehuwandu.
Nucala for Asthma
Zvimwe zvakasiyana zvakasiyana-siyana zvebiologic asthma zvinodhaka zviri mukugadzirwa kutarisa marudzi akasiyana-siyana ehuputi ayo angasapindura pane zvigadzirwa zvemazuva ose kana Xolair. Zvinyorwa zviviri zvebiologic zvakagamuchirwa kunopera 2015 uye kutanga kwegore ra2016 pakurapa chirwere chakasimba chinoratidzwa nehuwandu hweropa kana sputum eosinophils.
Nucala (mepolizumab) inonzi monoclonal antibody inokonzera IL-5, chiratidzo chekemikari yakagadzirwa nemuviri inokonzera kugadzirwa, kukura, uye kushandiswa kwemaoinophils. Eosinophils ichena masero eropa ayo anogona kukonzera kukuvara kwemuviri, kuvhiringidza, uye musimba simba mumapapu e asthmatics.
Nucala inoshanda nekupikisa migumisiro yeLI-5, zvichiita kuti kuderera kwehuwandu hweputum uye ropa eosinophils. Pakutanga zvidzidzo ne mepolizumab zvakakundikana kuratidza chero rubatsiro rwechiitiko ichi kuvanhu vazhinji vane astmma. Zvisinei, vanhu vane chirwere chakanyanya uye yakakwirira yepukamu kana ropa eosinophils yakaratidzika kuva nani nekushandiswa kwe mepolizumab.
Kunyanya, vanhu vane chirwere ichi cheputi vaikwanisa kuderedza mazamu avo emuromo corticosteroids akatorwa kuti vararame mweya yavo, vakave nekugadziriswa kwehutachiona (vashoma zviratidzo zvechirwere,) uye vakave nehuwandu hwehutachiona hushoma munguva. Zvimwe zvidzidzo zvakaratidza kuti pane kuvandudzwa mumapapu ekushanda kwemapapu pachitora Nucala.
Nucala inoratidzirwa kurapwa kwakaoma, maitiro eosinophilic asthma mune vanhu vane makore gumi nemaviri nekuresa avo vasingagamuchiri kuwanzopodha remishonga. Nhamba yacho yakafanana kune vanhu vose, pasinei nezera, kuyerwa kana eosinophil-iyo yemamirigiramu 100 inopiwa pasi pemutana sejojo mavhiki mana.
Zvimwe zvinokonzerwa naNucala zvakafanana nezvo zve placebo injections, kunyange zvazvo nguva dzose kune hanya nevanaphylaxis sechikamu chemagetsi nemishonga inokonzerwa ne biologic. Chiyero chevanaphylaxis chaive chikamu chimwe chezvikamu zveNucala, asi maviri muzana kune avo vanogamuchira nzvimbo inonzi placebo. Kunyange zvazvo Nucala isina bhokisi rakasarudzirwa nevanaphylaxis, vanhu vanogamuchira zvirwere zveNucala vanofanira kunge vakaongororwa nokuda kwehutano husingaitiki kwenguva yakareba nachiremba anoziva mukurapa vanaphylaxis.
Cinqair for Asthma
Cinqair (reslizumab) inoshanda nenzira yakafanana saNucala-inonziwo monoclonal antibody inopikisana neI-5, asi iri mamolekari akasiyana.
Cinqair inoshandawo kuderedza kuwanda kwepukamu uye ropa eosinophils, inovandudza zviratidzo zvechirwere uye mapapu, uye inoderedza kuwedzera kwekuita mu asthmatics nepamusoro yeputum uye ropa eosinophils. Cinqair inoratidzika inobatsira zvikuru mumutsara we asthmatics nemasipiritsi emaspuru kubva mukukura kwepalp polyp inoratidzika kushandiswa neI-5.
Cinqair inoratidzirwa kurapwa kwakaoma, maitiro eosinophilic asthma mune vanhu vane makore gumi nemasere kana kupfuura avo vasingateereri pane zvinowanzoitwa asthma therapies. Nhamba yacho inorema-yakagadzirirwa uye inoendeswa sechirwere chinoputika mavhiki mana. Mutengo wevanaphylaxis kune vanhu vanogamuchira Cinqair ndi 0.3 muzana uye saka vane bhokisi rakasangana rinonyevera zvakafanana neXolair.
> Sources:
> Patterson MF, Borish L, Kennedy JL. Yakare, Nhasi uye Ramangwana reMonoclonal Antibodies kune IL-5 uye Eosinophilic Asthma: Kudzokorora. Zvinyorwa zveAphma uye Allergy. 2015; 8: 125-134.