Antihistamines kazhinji inoshandiswa mishonga yekurapa yeorgenic rhinitis , pamwe nezvimwe zvinetso zvehutano zvakadai sokushaya hope, kusuruvara uye kurutsira, chirwere chinotyisa uye chirwere. Iyi mishonga inowanzoshandiswa panguva yekudzivirira, sezvo akawanda antihistamine ane kamu yeboka B yekuyera , pamwe chete nekuti akawanda antihistamine anowanikwa pane-the-counter (OTC) pasina mushonga.
Saka, kana kazhinji inonzi "yakachengeteka" munguva yekubata pamuviri, kune huwandu hweshamwari dzakapfuura pakati pevakadzi vane pamuviri vanotora antihistamines munguva yekutanga yevatatu uye dzakasiyana-siyana dzekuberekwa.
Masangano Anokwanisika Pakati PeAnhistamine uye Kuzvarwa Kwekuzvarwa
Masangano pakati peanhistamines akatorwa munguva yekutanga yekutatu kwemimba uye zvimwe zvirema zvinosanganisira:
- Diphenhydramine (Benadryl) : Cleft lip uye cleft palate , neural tube defects, Spina Bifida , zvipembenene zviduku zvinokanganisa , gastroschisis .
- Loratadine (Claritin)) : Hypospadias .
- Chlorpheniramine (Chlor-Trimeton)) : Kutadza kwemaziso , nzeve dzekunzwa, Spina Bifida, kuvhara mumuromo uye kuchenesa pane.
- Doxylamine (Unisom)) : Cleft lip uye cleft palate, pyloric stenosis, hypoplastic yakasara yemwoyo syndrome, Spina Bifida, uye neural tube defects.
Zvichida kuti vanenge vanenge 15 muzana yevakadzi vane pamuviri vanoparidza kubata antihistamine munguva yavo yekutanga, rimwe boka revanotsvakurudza kubva kuBoston, Massachusetts, neSingapore vakatsvaka kugadzirisa kuchengetedzwa kweva antihistamines yakatorwa munguva yekutanga yechitatu yekudzivirira.
Vatsvakurudzi vakatsvaga mashoko akaunganidzwa kupfuura makore gumi nemaviri, kubva muna 1998 kusvika muna 2010, pavana vanopfuura 13 000 vanoberekwa vane zviremera zvekuberekwa, uye vakazvienzanisa nevanenge vanenge 7 000 vacheche vasina zvirwere zvekuberekwa. Inenge 14 kubva muzana yevana vose vakange vasangana kune antihistamine dzakasiyana-siyana amai vakatora munguva yekutanga yekutora pamuviri.
Mamwe antihistamine, akadai saBenadryl naClaritin, akawedzerwa munguva yekuzvitakura kwemakore, apo kushandiswa kwemamwe antihistamine, akadai seChlor-Trimeton neUudom, uye zvayakaderera.
Inonzi Antihistamines Inoonekwa Yakachengeteka Panguva Yekubata?
Nhoroondo kubva pane ino yekudzidza inokurudzira zvikuru kuti antihistamine inowanzoonekwa yakachengeteka panguva yekuzvitakura. Sangano rekare rekushandiswa kwe antihistamine panguva yekutanga kwekutatu uye kuberekwa kwekuberekwa kwakanga kusina kusimbiswa munyaya ino. Zvisinei, mukuedza kuongorora njodzi yekuvandudza mamwe maitiro akaberekwa ekuberekwa, vatsvakurudzi vakawana sangano pakati pekushandiswa kweChlor-Trimeton uye chero ipi zvayo yechipfupa chekutsvaira uye ine dzakasiyana-siyana dzepfungwa dzisina kunaka. Paivawo neshamwari pakati pekushandiswa kwaBenadryl uye rumwe rudzi rwepenital heart malformation ( kuchinja kwemasimba makuru ). Zvisinei, vanyori vanongwarira kuti vaone kuti izvi ndezvenherechedzo dzinoda kudzidza zvakanyanya.
Saka, kunyange pasina chinhu chakadai semishonga yakakwana yakachengeteka panguva yekuzvitakura, kushamwaridzana kwakaparadzana pakati pekushandisa antihistamine munguva yekutanga kwemamiriyoni matatu uye kukanganisa kuberekwa kwakanga kusina kusimbiswa mune zvidzidzo zvenguva ichangopfuura. Kunyange zvazvo akawanda antihistamines aripo OTC pasina mushonga, vakadzi vane pamuviri vanofanira kutsvaka mazano kune chiremba vasati vazotora chero mishonga, kunyanya munguva yekutanga katatu yekuita pamuviri.
Chero mishonga inotorwa panguva yekuzvitakura inotorwa zvakanakisisa nokuda kwechinguva chiduku chenguva, uye pamwero wakaderera unoshanda pakurapa zviratidzo. Kubatsirwa kwekutora chero mishonga kunofanira kuyerwa pamusoro pengozi yokusatora mishonga.
> Sources:
> Li Q et al. Kuongorora kweAnhistamine Kushandiswa Mukutanga Kuberekwa uye Kuzvarwa Kwekuzvarwa. J Allergy Clin Immunol. 2013; 1: 666-74.
> Honein MA, et al. Kuchengetedzwa kana Njodzi yeAn antihistamine Kushandiswa Mukubata: Kuvandudza Dzakabatana Kunobatsira Asi Hazvikwanisi. J Allergy Clin Immunol. 2013; 1: 675-6.