Kudzivirirwa, migumisiro yechirwere, nezvimwe
Xolair (omalizumab) inonzi injectable mishonga inoshandiswa kurapa kuenzanisa kusvika kune zvakanyanya zvinokonzerwa nehutachiona . Inogona kushandiswa kune vanhu vane makore gumi nemaviri kana kupfuura avo vanoramba vasina kudzora mweya wehupenyu pasinei nemishonga inoshandiswa nehutachiona , sezvinonzi inhaled steroids .
Injection inopiwa muhofisi yechiremba kwemavhiki maviri kusvika mana zvichienderana nehuwandu hwomunhu uye yeaergic antibody (IgE).
(Tarisa kuti uone kana chirwere chako chinotungamirirwa nekutora chirongwa chekudzivirira chimu.)
Chii Chaizvo Chiri Xolair?
Xolair inonzi monoclonal anti-IgE antibody iyo inosunga kuGG muropa, zvichibvumira muviri kubvisa. Mishonga inobudiswa mumakonzo uye naizvozvo inenge anenge mashanu muzana mouse protein (inenge isingaoneki kuti kunyoreswa kumaproteni kunokonzera matambudziko kune vanhu vanogamuchira Xolair).
Izvi zvinodzivirira IgE kubva pakubatanidza kune mast cells uye kusunga kune zvose zvinokonzera, izvo zvinozoguma zvichiguma mukubudiswa kwe histamine nemamwe makemikari. Izvi ndezvikemikari zvinokonzera kuipa kwechirwere uye zvimwe zviratidzo zvekurwisa.
Chirwere ichi chave chiratidzwa kuti chideredze kurwisa kwechirwere, kuvandudza hutano hwehupenyu hwevanhu vane mweya weharu, uye kuderedza corticosteroids inodiwa. Kazhinji, zvinogona kutora mwedzi mishomanana yejojo ye Xolair kuti itange kushanda. Uye mishonga inogona kudhura.
Xolair haisi mushonga wehutachiona-zviratidzo zvaizotarisirwa kuwedzera humwe mwedzi mishomanana pashure pokunge chirwere che Xolair chimira.
Kutora Xolair Ngozi Here?
Xolair iye zvino ane "black box" nyevero, iyo inonzi chirevo chekuchengetedza chakapiwa mishonga neU.S. Food and Drug Administration (FDA). Iyi nyevero yakauya pamusoro pemigumisiro yevanhu vanotarisana nevanaphylaxis (inonzi reaction) shure kwekugamuchira Xolair.
Kunyange zvazvo pasina hurumende yehutachiwana anaphylaxis nemhaka yeXolair, dzimwe mhaka dzave dzakaoma uye dzinogona kutyisa upenyu. Nokuda kwechikonzero ichi, FDA inoda kuti vanhu vakagamuchira Xolair vaongorore muhofisi yechiremba wavo kwenguva yakati mushure mokunge vakuyiwa. (Iko chaiyo yenguva yakatarwa nachiremba.)
Vanhu vanogamuchira Xolair vanofanira kutarisa zviratidzo zvinotevera zvevanaphylaxis, iyo inogona kuitika kusvika maawa makumi maviri nemana (kana kupfuura) mushure mokujaira:
- Kusuruvara, kufema kufema, kufungira, chifu chechisimba, kana kunetseka kufema
- Low blood pressure, chizuru, kupera, nekukurumidza kana kushaya mwoyo
- Kusvetwa, kuchenesa, mikoko, kana kupfugama
- Nausea , kurutsa , chirwere , kana kurwadziwa mumimba
- Kutamba kwehuro, rurimi, miromo, kana maziso
- Nyaya yakaoma, inzwi rinopenya, dambudziko rinomedza
- Nenguva isipi kushungurudza kwakanyanya, mhepo yakasimba inoputika, kana kuputika kweputi
- Kuzvidya mwoyo kana kunzwa kwekutya
Kana chimwe chezviratidzo izvi zvichiitika, zvakakosha kuzivisa chiremba wako pakarepo. Vanachiremba vakawanda vanorayira varwere vane chirwere chinonzi epinephrine chinoshandiswa pakushandisa vanaphylaxis maawa makumi mana mushure mokunge vashandise Xolair.
Kuwedzera kweKanazi njodzi
Munguva yekurapa kwechipatara, mitero yekenza yakanga yakanyanya kudarika kune vanhu vanogamuchira Xolair vachienzanisa nevanhu vanogamuchira nzvimbo inonzi placebo.
Mhando dzekenza dzakaratidzwa kune vanhu vanogamuchira Xolair dzinosanganisira kenza yemazamu, kenza yepachifu, uye kenza yeprostate. Izvo zvisiri kuzivikanwa kuti zvinogona kuitika kwenguva yakareba sei zveHolaira zvinoshandiswa kune vanhu vanogona kuwana kenza, sevakwegura.
Kunyange zvazvo zvingaita sokuti Xolair ine mikana yakaipa, inofanira kuyeukwa kuti anaphylaxis nekenza yakagadzirwa chete mudiki kadiki yevarwere. Izvo zvisingazivikanwi nei izvi zvikamu zvinokonzera zvikaitika, kunyange zvazvo zvidzidzo zviri kuenderera mberi kuziva chikonzero.
Zvakakoshawo kuziva kuti kusadzora kwechirwere chinogona kutungamirira kumatambudziko makuru, kusanganisira kufa.
Uye mishonga inoshandiswa pakurapa masimba ekurwisa, zvakadai semuromo uye inoraswa corticosteroids, ine nguva yakareba yemigumisiro ine nguva refu. Saka, zvinokosha, kukurukura nachiremba wako njodzi uye zvikwereti zvekutora Xolair nokuda kwechirwere chisina kutarisirwa pamishonga inoshandiswa nemapirma.
Xolair yeimwe Utano Mamiriro
Tsvakurudzo dzinoverengeka dzakasiyana dzakaongorora kubatsirwa kwe Xolair yekurapa chronic idiopathic urticaria (mikoko), kana CIU. Kunyanya kutsvakurudza kwakaongorora varwere vanopfuura 300 vane CIU avo vakanga vachiri nezviratidzo zvisinei vachiita zvirwere zvinowanzoitwa antihistamine.
Zvidzidzo zvakapiwa Xolair mumatare akasiyana-siyana masvondo mana. Makumi makumi mana nevana kubva kune vanhu vanowana chirwere chakakwirira che Xolair, uye 22 kubva muzana yevanhu vanowana mizinga-dose Xolair, vaiva nehutano hwakakwana hwemuchiva mukati memwedzi imwe chete kusvika kwemaviri ekurapa. Zviratidzo zvishoma nezvishoma zvakapera mushure mokunge Xolair yakamira, saka pakange pasina chiratidzo chekugara kwenguva refu. Muna March 2014, FDA yakabvumira kushandiswa kwe Xolair yeCIU.