Estrogen Crash: Kurapa Kutanga Kuenda Kumwedzi
Gore roga roga zviuru zvemadzimai ari pakati pemakore gumi nemakumi mana nemana makumi mana nemashanu vanowana "Estrogen Crash", kamwe kamwe inodonha mazinga eestrogen anosiya vakadzi mumakumbo ekutanga kuenda kumwedzi. Kunyangwe kumisa kwemaitiro kunowanzoonekwa sechinetso kuvakadzi vakwegura, vakadzi vakawanda vaduku vanoona kusangana kwokutanga kwemazuva vanozviwana vasina kugadzirira kuchinja kusingatarisirwi kunoitika.
Estrogen Crash inowanikwa apo maviri omukadzi ari kubviswa kana kuti pakarepo anoramba kushanda. Kana izvi zvichiitika muviri unorega kubudisa isrogen .
"Sezvineiwo, vakadzi vane manopausal vanowedzera zvishoma nezvishoma mumazinga eestrogen pamusoro pemakore maviri kusvika gumi. Kusiyana neizvi, isrogen yakabuda yevakadzi vaduku vakambosangana nekuvhiya kwemazuva kana kukanganiswa kwemaawa kunoparadzwa zvishoma," akadaro Dr. Lila Nachtigall, MD, Mutungamiriri yeChipikirwa cheMukadzi muNew York University Medical School. "Mhedzisiro ndeyokuuya nekukurumidza uye kwekurumidza kwezviratidzo zvevasomotor: kupisa kunopisa, kusuruvara kweusiku , kuvhiringidzika kwehope dzakabatana uye kuomeswa kwemadzimai."
Vakadzi vanopfuura hafu yemamiriyoni vanoita hutano gore negore muUnited States uye zvishoma nezvishoma hafu yehusterectomi dzinosanganisira oophorectomy mairi - kubviswa kwemaviri mavari. Vanopfuura makumi maviri kubva ku20 kubva kuvakadzi vanoenda kune imwe nyika yepamusoro yeOophorectomy vari pasi pemakumi mana. Inenge mugore rimwechete 100 vakadzi vachakurira kusakanganiswa kweivarian vasati vava nemakore makumi mana.
Kurambana nekuEstrogen Crash
Vakadzi vanoona nguva yekuenda kumwedzi vasati vasvika vanowanzova nekuguma kumwedzi kwakasiyana kwazvo nevakadzi vanoona kusununguka kwepanyama pazera remakore. Mukuguma kwemazuva ekupedzisira, isrogen levels dzinopera zvishoma nezvishoma pane imwe nguva kubva pamakore maviri kusvika gumi, asi kuvhiringidzika kwevakadzi vane menopausal vanosangana kamwe kamwe muestrogen.
"Nenzira yakawanda, mukadzi anofamba nekubuda kwemhuka haazooni zviratidzo zvevasomotor nguva dzose," akadaro Dr. Lila Nachtigall. "Izvi zvinowedzera mberi, murwere angave nemwedzi wakaipa pano kana kuti, asi munyaya yeiophorectomy, migumisiro yakawanda zvikuru uye varwere vaduku, kunyanya, vanogona kukundwa zvakanyanya."
Muitiro waDkt. Nachtigall, 100% yevakadzi vane chirwere chevarume vane chirwere chevarume vane vasomotor zviratidzo uye 90 muzana yevakadzi ava vane zviratidzo zvakaoma zvakapedzisira zvave makore 8.5. Kusiyana neizvi, nepo nehuwandu huwandu hunosvika 85% hwevakadzi vanowanzova nevakadzi vane chirwere chinopisa, asi chete 15% vanoona zviratidzo zvakaoma. Panguva iyo vakadzi vanosvika pakuguma kwemwedzi, inenge 43% inorondedzera kuenzanisa kusvika kune zviratidzo zvakaoma zvinopedzisira mushure memakore maviri.
Vakadzi vanoona kusununguka kwemazuva mashure mushure mekunge vaine oophorectomy vanogara vachirwara nguva pfupi mushure mekuvhiyiwa kuedza mapiritsi. Kazhinji vanachiremba vanopa chirwere chestrogen chinoputika paganda uye chinopa esrogen kuburikidza neganda richipinda mumaropa kwemazuva akawanda. Kubatsirwa kwe estrogen patch ndiyo nguva yakabudiswa.
Zviduku pane zviduku izvi ndeyeVivelle-Dot. Iko .05 mg / zuva rekuita chiyero chekukura kwechitema chemasitendi uye inenge 75% zvishoma kudarika maestrogen patches.
Inopfekwa pamadziro ari pasi apo inopa isradiol kuburikidza ne transdermal skin patch muropa. Estradiol ndiyo nyanzvi yesrogen inogadzirwa nemayamu. Vivelle-Dot inoshandurwa kaviri vhiki imwe neimwe uye inopedzisa kuburikidza nemvura, kushambira, uye mamwe mabasa ezuva nezuva pasina kubuda. Chikwata chinopa zororo kubva kunopisa, kuputika kweusiku, uye zvimwe zviratidzo zveEstrogen Crash kana kubuda kwemhuka.
Vivelle-Dot inowanikwa mune dzimwe nhatu nhatu dzezviyero; .0375, .075, uye .1 mg / zuva. Zviitiko zvinowanzozivikanwa zvinowanzotaurwa zvinenge zvinyoro zvinyoro uye kusuruvara kweganda zvishoma.Systemic zviitiko zvinotambudza neVivelle (R) * (estradiol transdermal system) uye placebo, maererano, zvinosanganisira misoro (36% vs. 30%), mazamu emvere (4.9% vs 1.1%), uye kuchengetedza mvura (3.8% vs.2.2%).
Vamwe varwere vanotora Vivelle-Dot (TM) 0.0375 mg / zuva vanogona kutora kunonoka kwekubudirira.
Vamwe vakadzi havafaniri kushandisa isrogens. Izvi zvinosanganisira vakadzi vanozivikanwa kana kuti vanofungidzirwa kuva nepamuviri, kusawanikwa kwechirwere chisina kujairika, kushaya kenza yemazamu, estrogen-dependent neoplasia, thrombophlebitis inoshanda kana zvinetso zvepromboembolic, kana nhoroondo yakanyorwa yemamiriro aya. Estrogens dzakataurwa kuti dzinowedzera dambudziko re endometrial carcinoma mumashureopaopausal vakadzi.
W. Neil Jones, Mutevedzeri Mukuru Wemabhizimisi uye Sales of Noven Pharmaceuticals, Inc. inoti mhizha nehutano hwehutano inofanira kubatsira vakadzi vaduku kuti vanzwisise migumisiro inokonzerwa neEstrogen Crash kuitira kuti vazokwanisa kuita chisarudzo chakanaka kana vakazviwana vachitarisana ne kutanga kuenda kumwedzi.
Vivelle-Dot (TM) inotengeswa neNovogyne Pharmaceuticals, kubatana kwekubatana pakati pe Novartis Pharmaceuticals Corporation yeEast Hanover, New Jersey, uye Noven Pharmaceuticals, Inc. kuMiami, Florida.
* Chimiro chepakutanga (Vivelle) (R) chakaongororwa mumatambudziko emakiriniki chave chichirongedzwa kuti kuderedze hukuru hwepatch uye kuumbwa kwakarongeka (Vivelle-Dot) (TM) kwakaratidzwa kuva yakafanana neyokugadzirwa kwepakutanga.
Nhoroondo yepaIndaneti: PRNewswire / NEWSdesk