Hand-foot syndrome panguva yechikemikari
Hand-foot syndrome (HFS), inozivikanwawo semiti yemichindwe eerythrodysesthesia, inonzi dermatological side effect yemamwe chemotherapy uye mishonga yemishonga inorapwa. Iyo inonyanya kukanganisa zvanza zvemaoko nemaoko emakumbo. HFS inowanikwa apo maduku maduku emishonga anokonzera kunze kwemasvikiro uye anokonzera kukuvadzwa kwezvisikwa zvakajeka. Vanhu vazhinji vane HFS vanokudziridza migumisiro yakaipa, asi vamwe vanogona kutambura nemigumisiro yakaipa, kuita mabasa ezuva nezuva anenge asingakwanisi.
Chemotherapy uye Targeted Therapy Zvinodhaka Zvingaita Kuti Hand-Foot Syndrome
Hand-foot syndrome inowanzobatanidzwa nechirwere Xeloda (capecitabine) *. Mimwe mishonga inonzi inozivikanwa kuti iite ruoko-foot syndrome inosanganisira:
- 5-FU (fluorouracil) *
- Cytosar-U (cytarabine)
- Adriamycin (doxorubicin) - inopfuurira kuiswa
- FUDR (floxuridine)
- Doxil (liposomal doxorubicin)
- Idamycin (idarubicin)
- Nexavar (Sorafenib)
- Sutent (Sunitinib)
Ramba uchiyeuka kuti havasi vanhu vose vanotora mishonga iyi yemukenza vachakudziridza hand-foot syndrome.
* Dihydroprimidine dehydrogenase inoshaya (DPD) - ine sarudzo yakasiyana yemasikiriti emagetsi kunowanzoitika - ndiyo inokonzerwa neHFS yakakomba uye yakakurumidza inoitika nekushandisa kwemishonga iyi. Inowanzoperekedzwa nehutachiona hwakasimba. Vanenge 5% veAmerica vane kukwana uku. Kuedza kwacho hakusi tsika, asi chiremba wako anogona kuita saizvozvo kana uchida kutora rimwe remishonga iyi.
Zviratidzo zveHoko-Foot Syndrome
Zviratidzo zvinowanzobatana ne-hand-foot syndrome zvinosanganisira:
- Kutaura kana kupera
- Burning
- Rufu
- Kuzvimba
- Tenderness
Muzviitiko zvakakomba zve-hand-foot syndrome, ganda rinogona kutanga kutumbuka kana kukura maronda kana masonda. Dry, ganda rakasviba iro rinogona kana risingaiti ganda rinogonawo kuitika. Izvi zvinogona kukanganisa humwe hupenyu hwehupenyu, kunyanya kukwanisa kwake kufamba uye kushandisa maoko ake.
Mumakiriniki ekuedzwa, anenge 5% kusvika 10% muzana yevanhu vakaona izvi zvinokonzerwa nemaoko-foot syndrome.
Fingerprint Loss uye Hand-Foot Syndrome
Fingerprint kurasikirwa yakabatanidzwa nekushandiswa kwemishonga yemukenza inokonzera hand-foot syndrome . Izvi zvisingabviri rutivi rwunofungidzirwa kuti rwakabatana nehurefu hwenguva iyo mushonga unotorwa. Kuvhiringidzika nekuputika kweganda pane nguva kunogona kuita kuti minwe ye minwe iparadzwe. Hand-foot syndrome yakawana hurukuro yakawanda yevhepfenyuro muna 2009 apo mumwe murume weSingapore akavharirwa kuUnited Customs nekuda kwekusava neminwe yeminwe. Mamiriro ake ainge akabatana nekutora Xeloda (capecitabine) kwemakore matatu.
Kudzivirira uye Kutarisira Hand-Foot Syndrome
Kudzivirira chinhu chinokosha neHFS. Kupisa uye kukakavadzana zvinhu zviviri zvinowedzera kuipa kwema capillary kuvuza. Kwevhiki mushure mokunge wapiwa mishonga IV, kana kuti nguva yose uri kutora chirwere chepuropa remuromo, pane zviverengero zvakawanda zvaungatora kuti ubatsire kudzivirira uye kutarisira HFS:
Dzivisa Mvura Inopisa - Kuratidza ganda kumvura inopisa kwemazuva akawanda (kutora mabhati nemvura, semuenzaniso), kushambidza muviri, uye kunonoka mumoto unopisa hausi kukurudzirwa. Kutora mvura yakasvibira kana yenguva pfupi yakanakisisa kwevhiki imwe mushure mokutora IV med med kana kuti panguva iyo iwe uri kutora mishonga yemuromo.
Rubber magamba haabvumiri - vanopisa maoko. Chiremba wako anogonawo kukurudzira kuti iwe pachako usatora mvura inopisa kana kushambidza maawa makumi maviri mapfumbamwe asati apora.
Dzivisa Kuita Zvekuita uye Basa Remaoko - Kuita zvekuita izvo zvinokonzera kushungurudzika kukuru uye kushungurudzwa pamaoko nemakumbo, zvakadai seaerobics, kufamba kwenguva refu, kutamba, uye weightlifting (kunyange nemagetsi), inofanirawo kudziviswa. Basa rebhuku rakafanana nebindu rekurima uye jare rinofanirawo kudziviswa.
Kupfeka Zvisungo Zvakakodzera Zvokugadzirira - Zvokufuka zvakakodzera uye shangu zvinogona kukonzera kupesana, izvo zvinotungamirira kuwedzera capillary kuvuza. Kupfeka shangu dzakasununguka nemakumbo akatsika.
Usafamba usina tsoka; Sokoni masokisi kana soft slippers zvakanakisisa.
Usapfeka zvipfeko - Kuti urege kupesana, usapfeka zvindori paminwe yako. Nheyo dzisina kumbobviswa, seyindori dzechikwata, dzinogona kuva mabakiteriya zvakare. Bhakitiriya inogona kuvharirwa mukati memhete uye munwe. Utachiona hwekudzivirira nekudzivirira hunokosha zvikuru neHFS nekuda kwekunzwa kweganda.
Chengeta Maoko Netsoka Zvakanaka - Muzuva rose, shandisa ice packs kana kuti kupera kunamatira maoko nemaoko. Kuzviisa mumvura kashoma pazuva kunobatsirawo.
Shandisa Emollients - Emollients ndiyo mikoko inoshandiswa inogadzirisa iyo inopisa ganda rakaoma, rakapwanyika, uye rinogumbura. Vazhinji vanachiremba vanokurudzira michina yakawanda yakadai seA Aveeno ne lanolin, Lubriderm, Udder Cream, Bag Balm, uye Aquaphor. Iwe unogona kushandisa emollients kanoverengeka pazuva, asi iva nechokwadi chokuti usasvina ganda nemhepo yakawanda. Kupfeka masokisi uye magirafu mushure mekushandiswa kunobatsira kuchengeta unyoro.
Gara Wakanyoroveswa - Kuderedza mvura kunokonzerawo ganda rakaoma, saka zvakakosha kuti uchengetedze zvakanaka nemvura zhinji. Caffeine inozivikanwa chikonzero chekushaya mvura uye inofanira kudziviswa.
Maitiro Ako Chiremba Anogona Kutarisira Hand-Foot Syndrome
Zvinyoro zvinyorwa zveHFS zvingasadire kupindira mune zvekurapa, kungongwarira iwe neukoti wako uye chiremba. Kana iwe ukatanga kucherechedza zviratidzo zveHFS, danaidza mukoti wako we- oncology kana kuti chiremba. Kana iwe uchitambura neHFS uye ukaona kuipa, zvakakosha kudana chiremba wako pakarepo.
Zvichienzaniswa nematambudziko makuru e-hand-foot syndrome zvinopesana nemabasa ezuva nezuva ehupenyu anoonekwa sechinhu chakakomba chekurapa, uye chinorapwa sechinhu chakadaro. Kurambidza kurapwa kana kuderedza kuyerwa kunogona kudiwa. Mishonga yemarwadzo yeOTC sezvinonzi ibuprofen inogona kukurudzirwa kuti ibvise marwadzo. Nhengo dzemumuromo kana mapikisi corticosteroids inogona kubatsira vamwe nekuputika. Chirongwa chisina-steroidal antiinflammatory drug Celebrex (celecoxib) inoratidzika sechinyatsoshanda kuburikidza nekuongorora kweongororo.
Maitiro makuru e vitamini B6 anowanzokurudzirwa kuvanhu vanogona kukura HFS kana kuti vanototambura nazvo. Oncologists inowanzokurudzira kushandiswa kwenguva pfupi kwema50 kusvika ku 150 mg yeB6, iyo yakakwirira kwazvo kudarika kukurudzirwa kwezuva nezuva. A 2015 meta-analysis - kugadziriswa kwezvidzidzo zvakabudiswa kusvika nhasi - zvakakundikana kuona kuti vitamini B6 yakabatsira chaizvo nehana-foot syndrome, asi vanhu havasi nhamba uye zvingave kuti vamwe vanhu vane kuvandudza kwezviratidzo. Nguva dzose bvunza chiremba wako usati watora vitamini B6 yeHFS. Zvimwe mavitamini uye zvicherwa zvinowedzera zvinogona kuderedza kushanda kwe chemotherapy .
Ongororo dzakawanda dziri kuitwa pamusoro pekudzivirira uye kutungamira kwemaoko-foot syndrome. Basa reicicinine, henna, uye vitamini E ndezvimwe zvinhu zvakawanda izvo zvave zvichidzidza nezvekusunungurwa kweHFS.
Sources:
Hoesly, F., Baker, S., Gunawardane, N., uye J. Cotliar. Capecitabine-induced hand-foot syndrome yakakomberedzwa ne pseudomonal superinfection inokonzera kubatwa kwebhakitiriya nekufa: nyaya yenyaya uye kuongorora kwezvinyorwa. Archives of Dermatology . 2011. 147 (12): 1418-23.
Jo, S., Shin, H., Jo, S. et al. Prophylactic uyerapautic effectiveness ye pyridoxine inowedzera mukutungamira kwemaoko-foot syndrome munguva yechemotherapy: meta-analysis. Clinical and Experimental Dermatology . 2015. 40 (3): 260-70.
Macedo, L., Lima, J., dos Santos, L., naA A. Sasse. Kudzivirira maitiro e chemotherapy-induced hand-foot syndrome: kurongwa kwakarongeka uye kuongororwa kwevanhu vanotarisa miedzo. Kuchengetedza Kuchengetedza muCancer . 2014. 22 (6): 1585-93.
McLellan, B., Ciardiello, F., Lacouture, M. et al. Regorafenib-yakabatana maoko-gumbo ganda rekuita: mazano anobatsira pakuzivikanwa, kudzivirira, uye kutungamira. Annals of Oncology . 2015. 26 (10: 2017-26.