Kurapa kweMeanoma Skin Cancer Ndiyo Yakare uye Inonetsa
Kurapa kweIferferon-alfa2b kwekemenamoma ndiyo chete inogamuchirwa mishonga panguva ino. Muenzaniso wokutanga kurapwa kwemaranoma ndiko kubviswa kushandiswa kwezvimwe zvipembenene, nzira inonzi yakakura nzvimbo yakanyanyisa . Zvichienderana nechikamu chechirwere chako, chiremba wako angabva ataura kuti adjuvant (mushure mekuvhiyiwa) kurapa kuderedza mukana wekuti melanoma ichadzoka (yakadzoka).
Somuenzaniso, kana maranoma akapararira kune imwe kana akawanda emakirini ako, pane inofungidzirwa kuti kusvika kune makumi manomwe kusvika ku80 muzana mukana wekuti melanoma ichadzoka mukati memakore matatu kusvika mashanu. Zvirongwa zvehutano hweAdjuvant iye zvino hazvikwanisi: kurapwa kwe-interferon-alfa2b (IFN) ndiyo chete inoshandiswa nemishonga inogamuchirwa kusvikira ikozvino. Kana yako oncologist yakurudzira interferon-alfa2b, huwandu hwepfungwa idzi huchakusimbisa nehutu hunonyanya kukosha hunodiwa kuti unzwisise kuti hunoshanda sei, kubudirira kwayo nemigumisiro yaro.
Cherechedza kuti ruzivo urwu harungagoni kuvhara zvose zvinogona kutarisirwa, kutaurirana kana kuipa kwechirwere ichi. Kana uine mibvunzo pamusoro pemishonga ipi yauri kutora, iva nechokwadi chekutarisa nachiremba wako.
Interferon-alfa2b
Inonziwo interferon-alpha2b, IFN uye Intron A, Interferon-alfa2b yakagamuchirwa neDain and Drug Administration (FDA) muna 1995. Mishonga inogamuchirwa kuti ishandiswe mumazuva makumi mashanu (masvondo masere) mushure mekuvhiyiwa nevarwere vane makore 18 kana kuti vakwegura vane chirwere chinorwarisa chinorwara chisingaiti chirwere asi vari pangozi yakakura yekudzoka (chirwere chinodzoka).
Varwere vari pangozi yakakura yekudzoka vanosanganisira avo vane melanoma muzvikamu zvinotevera:
- Nhanho yeIIB - matumbu anopfuura 4 mm (anenge 1/6 emasendimita) akareba pasina kuonda
- Nhanho IIC - matumbu anopfuura 4 mm marefu nehutonda
- Chikamu IIIA, IIIB, IIIC - matumbu anogona kuva chero zviyero asi chirwere chakapararira kune lymph nodes
Interferon-alfa2b yakasiyana nedzimwe mishonga yemakemikari - iyo inongova chikamu chemuviri wemuviri wako. Inonzi inozivikanwa se cytokine , iyo yemakemikari kazhinji yakavanzwa nemasero anonzi leukocytes mukurwisa utachiona, mabhakitiriya, kana vamwe vanoita kunze kwenyika. Iyo inobata kune dzimwe masero uye inokonzera dambudziko rakaoma rekuchinja (zhinji rayo risingazikamwi), kusanganisira kuderedza kuderedza kutengesa kwemasero ekuparadzanisa nekuderedza kukwanisa kwemasero kuzvidzivirira pachavo kubva mumuviri wesimba.
IFN yaishandiswa kurapa melanoma haina kubva mumuviri asi pane kuwanda-kwakagadzirwa mu laboratori uchishandisa maitiro ekugadzira genetic. Iine maitiro akafanana nehupenyu hwepanyama asi chaizvoizvo inonzi "recombinant" nekuda kwechikonzero ichi.
Uchapupu hwekubudirira kweInterferon-alfa2b
IFN ndiyo chete mishonga yevanhu vane ngozi yakawanda inouraya maranoma yakave yakaratidzwa kuti ivandudze zvakare kudzoka-kusasununguka kusararama (kurarama pasina chirwere ichidzoka) uye kurarama zvachose. Zvidzidzo zvitatu zvakaita kuti zvibvumirwe neDFA. Kutanga, nhamba yepamusoro yeFNN yakaenzaniswa nekusaita chinhu: Muchiitiko ichi, avo vanorapwa neFNN havana kudzoka zvakare nekukurumidza uye vakararama gore rimwe chete paavhareji. Mukuedzwa kwechipiri, nhamba yepamusoro yeFNN yakaenzaniswa neyatsika-dose IFN uye zvakare pakanga pane kuwedzera kukuru kwekudzokerazve-kusina kusununguka muboka revanhu vakawanda.
Zvisinei, kwakanga kusina mutsauko mukupona kwese. Pakupedzisira, apo IFN yakaenzaniswa nechirwere chekuedza chinonzi GMK, mitsva yakajeka: boka reFNN raive nekuvandudza kwe 47% mukudzoka kusina-kusununguka uye kubudirira kwehuwandu hwe 52% muhupenyu hwose.
Zvimwe zviitiko zvakawanda zvekuchipatara zvakaitwa (uye zvichiri kuitiswa) mukuedza kuwedzera kubudirira kweFNN. Zvinosuruvarisa, zvimwe zvidzidzo zvekare hazvina kuratidza sehukuru hunobudirira sezvakakosha - uye rumwe ruzivo rwa2008 (runonzi "Sunbelt" muedzo) rwakaratidza kusava nemigumisiro yeFNN pane varwere vane rimwe rakanaka sentinel lymph node - saka kushandiswa yeFNN yave ichikakavadzana pakati pechiremba.
Zvechokwadi, oncologists muEurope vave vachinyanya kuda kuisa IFN pamusana pemafungiro pamusoro pechibato chayo chiduku uye chakanyanya kuora. Kana uine mibvunzo kana zvinetso, iva nechokwadi chekutaurirana navo nachiremba wako.
Kushandisa Interferon-alfa2b
Mushure mekuvhiyiwa, IFN inopiwa mumatanho maviri: kuiswa uye kuchengetedza. Kunyunyuta kunosanganisira kugamuchira chiremba chakakwirira kuchipatara neine IV (intravenous) kukanganiswa kwemaminitsi makumi maviri, mashanu kuitevera kwevhiki kwevhiki, kwevhiki ina. Munguva yekuchengetedza chikamu, iwe inorovera doro rakaderera re IFN iwe pamba katatu pavhiki kwevhiki makumi mana. Inoraswa chete pasi peganda ( subcutaneously ), kazhinji muhudyu kana mudumbu. Iwe kana hama yako uchadzidziswa kupa majekiseni aya nemureri kana chiremba.
Zvichida Zvimwe Zvikamu zveInterferon-alfa2b
Kurapa ne IFN yakareba uye yakaoma. Zvisinei, nekutarisisa kwakakodzera, kuchinjwa kwechirwere, uye kushungurudzika kwechisimba, kunogona kupiwa zvakachengeteka uye kunogona kutarisirwa kune vazhinji vevarwere. Izvo zvikamu zviviri zvakajairika zvinokonzerwa neFNN zviratidzo zvinoputika (fever, chills, muscle uye joint aches) uye kuneta. Kuti ubatsire kuderedza zviratidzo izvi, tevera "ABCs":
- A cetaminophen (Tylenol)
- B edtime administration (ita majekiseni usati warara)
- C onserve energy
- D rinza mvura zhinji
- E pakudya zvakanaka
- F ocus pane zvakanaka
Zviratidzo zvakadai sechirwere zvinowanzoderera pamusoro penzira yekurapa asi kuneta kunowanzoramba uye kunogona kuwedzera.
Izvi zvinotevera migumisiro hazviwanzoiti asi zvakataurwa kune vanhu vakawanda vanotora IFN:
- Nausea, kurutsa
- Kushatirwa kweganda panzvimbo yejojo
- Chizutu
- Kuora mwoyo, kuzviuraya, uye mamwe matambudziko emanzwiro
- "Mipiro nemasero" kunzwa mune maoko nemakumbo
- Kuora bvudzi
- Yakaderedza chichena chekuyera masero eropa, izvo zvinogona kutungamirira kune hutachiona hwepamusoro uye chirwere chekushaya ropa
- Kuchinja kwechiropa chinoshanda
- Kuchinja mumwoyo rhythm uye ropa
Mimwe migumisiro inogoneka inogona kuitika saka iva nechokwadi chekukurukurirana navo nechiremba wako. Zvizhinji zvizhinji zvinokanganiswa zvichaenda kamwechete apo interferon-alfa2b therapy inomira.
Kuwirirana
IFN inogona kukuvadza zvimwe zvehutano hwako hwakagara huripo, saka taurira chiremba wako kana une:
- Hepatitis
- Chero zvirwere zvechiropa
- Chirwere cheshuga
- Chirwere chemoyo
- Chirwere chakaremara
Dheuteronomio:
"Melanoma." National Comprehensive Cancer Network. V.1.2009. 28 January 2009.
"Intron A Kunyora Mashoko." Kuchera-Plow. 28 January 2009.
Ascierto PA, Kirkwood JM. "Adjuvant therapy ye melanoma ine interferon: zvidzidzo zvemazana gumi apfuura." J Kushandura Med 2008 6: 62-70. 28 January 2009.