Humira Anoshandiswa Kurapa Kurwara kwaCrohn uye Rheumatoid Arthritis.
Humira (adalimumab) munhu anonzi monoclonal antibody. Inoshanda nokubvisa tumor necrosis chinonzi alpha (TNF-alpha) , cytokine iyo inobatanidzwa mubasa rinopisa.
Vanhu vane chirwere chinoputika chirwere (IBD) vane chimiro chisina kujairika cheN TNF-alpha, uye inofungidzirwa kuti iyi inobatanidzwa mukurapa kwechirwere. Huma anomira TNF-alpha kubva kushandiswa nemuviri.
Humira Anotorwa Sei?
Humira anouya nenzira yejojo uye inofanira kuchengetwa mufiriji. Iyo jira inopiwa pasi peganda (subcutaneously) pamba kana muhofisi yechiremba. Humira inopiwa kamwe chete kwevhiki imwe neimwe kana dzimwe nguva vhiki imwe neimwe. Nhamba yacho inowanzo 40 milligrams. Humira haafaniri kujowa munzvimbo imwe chete pamuviri kaviri mumutsara. Varwere vanofanira kuchinja pavanopa jira - kazhinji mudumbu kana mberi kwechidya. Kurapa chiremba kuchapa chero mirayiridzo inokosha uye kurondedzera nzira yekupa jekiseni kumba, kana zvichifanira. Kana uine mibvunzo pamusoro pekupa chirwere chacho, unogona kudana (800) 4HUMIRA (448-6472).
Nei Inorondedzerwa?
Humira inogona kurongerwa chirwere cheCrohn kana chironda chekurara, iyo miviri mikuru yeBD. Inowanzopiwa pashure pemimwe mishonga yakaedzwa uye haisi kushanda kana kana zviratidzo zveBD zvakanyanya kwazvo.
Humira inobvumirwa kuti ishandiswe kune vanhu vakuru uye kuvana vanopfuura makore matanhatu.
Humira inogona kuderedza zviratidzo zveBD zvinowanzoonekwa (kurwadziwa, kuneta uye kubuda) uye zvinogona kukurudzira kuregererwa. Mune imwe kliniki muedzo wevarwere vane Crohn's disease, 40 kusvika 47 muzana yevarwere vanobatwa neHumira vaiva mukuregererwa mushure memasvondo makumi manomwe ekurapa.
Mushure memasvondo makumi mashanu, vanenge 40% vevarwere vakanga vachiri mukuregererwa.
Ndiani Asingafaniri Kutora Humira?
Udza chiremba wako kana wakarongerwa kune chero rudzi rwekuvhiya kana kuti uine chirwere chinotevera. Uyewo rega chiremba wako azive kana iwe wakambove wakambova nemimwe mitemo inotevera:
- Allergic reactions kune chero mishonga
- Kanzira (lymphoma)
- Iye zvino ari pamuviri
- Fungal chirwere
- Heart failure
- Hepatitis B
- Lupus
- Multiple sclerosis
- Zvirwere zvekare
- Kugumburwa
- Tuberculosis
Ndezvipi Zvikamu Zvakaipa zveHumira?
Nzvimbo yakanyanya kufanana nayo yeHumira inorwadza, kutsamwa, kuzvimba kana kuchenesa panzvimbo yejojo. Mimwe migumisiro yakawanda inowanzobatana inosanganisira misoro, kuputika uye kusuruvara. Pane njodzi yekuve nehutachiona hwehutachiwana paunotora Huma, kunyange zvisingaiti. Taurira chiremba wako kana iwe ukakurira chero zviratidzo kana zviratidzo zvehutachiona kana kana imwe mimwe migumisiro inotambudza kana isingaendi.
Ndeapi Mishonga Inogona Kubatana Navo?
Hazvikurudzirwe kuti Humira inotorwa nevamwe veNTF-vanovhara, avo vari Kineret (anakinra), vachararama zvirwere kana methotrexate. Udza chiremba wako kana iwe uri kutora chero mishonga inodzvinyirira zvirwere zvemuviri, zvakadai se cyclosporine.
Pane Kubatana Kwezvokudya Here?
Hakuchina kushamwaridzana kwekudya kunozivikanwa.
Huma Anodzivirira Wakachengeteka Panguva Yekuberekwa Here?
Iyo FDA yakaronga Humira sechirongwa cheBhi B. Dzidzo pamhuka hadziratidzi uchapupu hwekukuvadza kumucheche; zvisinei, hapana hutano hwakakwana, hwakanyatsochengetedzwa mumadzimai ane pamuviri. Humira inofanira kushandiswa chete mumadzimai ane pamuviri apo inonyatsodiwa. Zivisai kunyora chiremba kana iwe ukava nepamuviri paunotora Humira.
Chimwe chekudzidza zvishoma chakaratidza kuti Humira anoyambuka murcenta uye anopinda muropa remucheche mukati mekupedzisira kwemwedzi yekuzvitakura. Huma aigona kuwanika muropa rechecheche kusvika kumwedzi mitatu mushure mokuberekwa. Zvinokurudzirwa kuti vana vakaberekerwa vanaamai vanotora Huma vanoongororwa zvakanyanya nezvehutachiwana hwemwedzi 6 yekutanga yehupenyu, uye vasingagamuchiri zvirwere zvehupenyu hwehupenyu panguva iyoyo.
Hazvizivikanwe kana Humira achipinda muchibereko chemuti; zvisinei, zvimwe zvinhu zvakafanana zvakaratidzwa kuti zvipinde mumukaka wemvere. Kuyamwisa mwana paanotora Humira hakukurudzirwi.
Chii Chandinoita Kana Ndisingasiyi Dose?
Kana iwe uchinge warasikirwa neipi, tora iyo pakarepo iwe uchiyeuka. Zvadaro tora nhamba yako inotevera pane nguva yakagara yakarongwa. Usapinda kaviri kana kutora kanopfuura dose imwe panguva.
Sources:
Abbott Laboratories. "Humira Mishonga Mishonga." Humira.com Mar 2011. 17 Apr 2011.
Colombel JF, Sandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Panaccione R, Schreiber S, Byczkowski D, Li J, Kent JD, Pollack PF. "Adalimumab yekuchengetedza kliniki yekupindura nekuregererwa kune varwere vane Crohn's disease: chirwere cheCARM." Gastroenterology 2007 Jan; 132: 52-65. 17 Apr 2011.
Mahadevan U. "Adalimumab Levels Zakatarirwa Mugambo Ropa nevana Vachiratidzwa MuUtero (Abstract # 277)" Chirwere Chepachivande Week 2011. 26 Feb 2012.
PDR Health. "Humira." Thomson Healthcare 2008. 17 Apr 2011.