Chinhu P Zvine Matambudziko Anotsvaira
Nzira yei Substance P yaive yazivikanwa
Chinhu P chakatanga kuwanikwa muna 1931, asi kukosha kwaro mumutumbi kwakatora makumi emakore kuti irege kubviswa. Pakazosvika makore makumi mashanu, zvakagadzirirwa kuti P P yaiva neurotransmitter. Masero emasero anonyorera kuburikidza neurotransmitters. Chinhu P chakawanikwa sechishanda sechinoshungurudza kurwadziwa kwechirongwa chetsitsi. Runyanga rwenheyo runoumbwa nemanzwiro emakumbo uye anowanikwa pamakumbo ose emusana.
Pakazosvika ma1970, zvipenyu zvehupenyu hweP P zvakaratidzwa. Substance P yakaonekwa seprotini yakagadzirwa nehuwandu hweamino acids.
Basa rezvinhu P muMutumbi
Mhuka dzakawanda uye in vitro zvidzidzo zvakaitwa kuitira kuti basa rezvinhu P muviri rinzwisiswe zviri nani. Vatsvakurudzi vakawana kuti zvinhu P zvakakonzera marwadzo kuburikidza nehutano hunonzi nociception. A nociceptor inonzi sensory neuron kana nerve cell iyo inopinda kune zvinogona kukuvadza zvinokuvadza nokuisa chiratidzo chepelinha uye uropi. Nociception inokonzera maonero ekurwadziwa. Yakawanikwawo kuti zvinhu P zvine proinflammatory effects.
Chinhu P uye iyo yakagadzirwa nemukuru, neurokinin-1 (NK-1) mutezo, inowanikwa mumakurendi ari munzvimbo yose yeurouroxis (iyo inosangana inopinda kuburikidza neuropi nemutsipa wesipinha). Nyeuroni idzodzo dzinobatsira mukurwadziwa, kunetseka, nekuzvidya mwoyo. Chinhu P chinowanikwawo muhumbichu yehutano hwenheyo, kusanganisira hypothalamus uye amygdala.
Iyi nharaunda dzakabatana nemafungiro emanzwiro.
Kunze kwekunzwisisa kurwadziwa, kushushikana, uye kuzvidya mwoyo, pfuma P yakawanikwawo kuti inobatsira mune dzimwe dzakawanda dzehupiologiki mhinduro:
- kurutsa
- maitiro ekuzvidzivirira
- kuchinja mumutauro wemwoyo
- kushungurudza kwekudzivirira kwekudzivirira
- smooth muscle contraction
- vasodilation
Substance P uye Arthritis
Vatsvakurudzi vadzidza kubatanidzwa kwezvinhu P mu arthritis uye chirwere chinopisa. Nokuda kwezvinhu P kufambisa basa mu arthritis, hurongwa hwekutya hunofanirwa kuve huchibatanidza mune pathophysiology yeArthritis. Iko kunofanirwa kunge kune nerving sensory innervation kusvika pamubatanidzwa . Zvimwe zvitsva zvinoratidza kuti ndezvokuti:
- Substance P yakawanika mune dzimwe nzvimbo dzinokosha.
- Chinhu P chinowanikwa munzvimbo yakakwirira mu synovial fluid ye rheumatoid arthritis patients.
- Nhamba yezvinhu P zvinogadziriswa zvakasiyana nedheumatoid tissue.
Levine et al. yakaronga kuti nzira dzechiredhi dzinogona kupa tsananguro yehumwe hukuru hwezvinhu zvakakosha zverheumatoid arthritis: manotsi anonyanya kuwedzera arthritis; majoini akasiyana anowedzera arthritis yakanyanya; uye chimiro chezvibatanidzi zvinokanganisa rheumatoid arthritis inobatanidza uye yakaenzana. Lotz et al. akawana chimwe chinokonzerwa nebasa P in arthritis. Lotz neboka rake vakaratidza kuti zvinhu P zvinogona kukurudzira synoviocytes (synovial cells) mu rheumatoid arthritis. Zvinhu P yakawedzera kusunungurwa kwe prostaglandin uye collagenase kubva ku synoviocytes.
Targeting Substance P
Ko kutsvakurudza kwebasa rePi P rakapa chirongwa chitsva cherheumatoid arthritis here?
Kwete chaizvo. Asi, vatsvakurudzi vanoti kune inogona kugadziriswa nhengo ye NK1 muchengeti (blocker) kuti ikurudzirwe semushonga we rheumatoid arthritis. Panguva ino:
- Glucocorticoids inogona kuderedza kuputika kunotangira muhutu hwemutsipa kuburikidza nekuderedza kutaura kwe NK-1, nepo kuwedzerwa kubudiswa kwemhepo inokonzera kukanganisa kwezvinhu P.
- Nyaya yepamusoro inonzi capsaicin inogona kubvisa pfuma P kubva munharaunda inogumira kugadzirisa marwadzo. Maererano neRheumatologist, Scott J. Zashin, MD, capsaicin anogona kutora masvondo 1 kusvika kuchina kuti ashande. Kuti uchengetedze kubatsirwa kwekununurwa kunorwadza, capsaicin inofanira kushandiswa patsva maererano nemirayiridzo.
Basa Rokunyora P riri muhutano Hwekutevera Kuvhiya
Tsanangudzo pamusoro pebasa rekushandisa P inotambura kurwadza nociception mushure mekuvhiyiwa kune varwere vane chirwere chisingaperi chisingabatsiri chinenge chisingabviri, sezvinozivikanwa pamusoro pekubatana pakati pezvinhu P zvinoshanduka pakuchinja uye kurwadziwa. Maererano ne PLOS One (2016), vatsvakurudzi vakaongorora kuwirirana pakati pezvinhu P zvinoshanduka kuchinja uye kusuruvara kwakanyanya kune varwere vane rheumatoid arthritis avo vakawana chirwere chemapfupa. Vakaona kuti kuwirirana pakati pekurwadziwa kwakanyanya uye zvinokonzerwa neP serum concentration zvakaitwa pashure pechirwere mune varwere vane rheumatoid arthritis, asi haina kuonekwa mumvura yakasviba.
> Sources:
> Garret NE et al. Basa rezvinhu P mukuputika kweArthritis . Annals of the Rheumatic Diseases 1992; 51: 1014-1018.
> Keeble uye Brain. Basa Rokushandisa P mune Arthritis? Neuroscience Letters. Bhuku 361. Nyaya 1-3, 6 Meyi 2004. Mapeji 176-179
> Levine JD, Collier DH, Basbaum AI, Moskowitz MA, Helms CA. Izvozvi: chirongwa chebve chinogona kuita kuti pathophysiology ye rheumatoid arthritis iite. Journal of Rheumatology. 1985, 12 (3): 406-411.
> Lisowska, B. et al. Chirwere P uye Chirwere Chine Utano Muvarwere Vanopinda Chirwere. PLoS One. 2016 Jan 5; 11 (1): e0146400. doi: 10.1371 / magazini.pone.0146400.
> Lotz M, Carson DA, Vaughan JH. Chirongwa P kushandiswa kwerumatoid synoviocytes: neural pathway mupathogenesis yeArthritis. Sayenzi. 1987 Feb 20; 235 (4791): 893-5.
> O'Connor T et al. Basa Rechiito P mune Zvirwere Zvirwere. Nyaya ye Cell Cell Physiology. 2004 Nov; 201 (2) 167-80.