FDA-Approved Hepatitis C Zvinodhaka

Mishonga inopa mushonga wehutano hwehupamhi hwepamusoro se 99 muzana

Apo mishonga yeSovaldi (sofosbuvir) yakatanga kubudiswa munaSeptember 2014, haina kungotarisa kugadziriswa kwegungwa mukurwara kwehutachiona hweH hepatitis kwakagadziriswa, yakaita kuti kusashandiswa kwemishonga yerudzi rwekare isati yasvika iyo yakanga isiri pedyo neinobudirira. Mumwedzi yakawanda yeSalvaldi kusvika, iyo hepatitis C inowedzera seIncivek (telaprevir) naVictrelis (boceprevir) vakakurumidza kubuda mumusika, kusingazoonekwi zvakare.

Kutevera zvakasimba pazvitsitsinho zveSovaldi kwaiva kuiswa kwezvimwe zvitanhatu zvinodhaka zvinodhaka zvinogona kubata chirwere chakawedzera chema hepatitis C. Mishonga iyi mitsva haina kungova nemigumisiro shoma shoma, yakaderedza chirongwa cherapi nemwedzi mitatu.

Nekurapa mazinga iye zvino anopfuura 95 muzana mumatambudziko akawanda, iyo chete inetso yakaoma ndeyekuwedzera kuwanika kune vanhu 130 kusvika 150 mamiriyoni vane chirwere cheHpatitis C pasi rose.

Heino hupfumi hutsva hwehutachiona hweH hepatitis C, hwakanyorwa nehurongwa hwekugamuchirika kwaVaDear:

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Epclusa

Yakagamuchirwa musi waJune 28, 2016, Epclusa (sofosbuvir, velpatasvir) ipiritsi inobatanidza maviri-in-imwe inogona kubata maitiro matanhatu makuru ehepatitis C. Inogona kushandiswa kuporesa vanhu vane cirrhosis (kusanganisira chibharo cheprhosis ). Epclusa inorayirwa mune imwe nguva yemazuva zuva rimwe nerimwe kwemavhiki matanhatu.

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Zepatier

Yakagamuchirwa munaJanuary 2016, Zepatier (elbasvir, grazoprevir) inoshandiswa-inoshandiswa inoshandiswa mishonga inoshandiswa kurapa genotype 1 uye 4 ine kana isina cirrhosis. Zepatier chirwere chepilisi imwe chete iyo haifaniri kutarisirwa nemumwe mishonga. Inotorwa kamwe chete zuva rega rega kana kuti isina kudya kwemavhiki 12 kusvika ku16, zvichienderana nerudzi rwejenotype munhu ane uye kana kana kwete munhu wacho akamborapwa kuti ave nechipatara C.

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Daklinza

Yakagamuchirwa munaJuly 2015, Daklinza (daclatasvir) inoshandiswa mukubatanidza kurapa kurapa hepatitis C maitiro matatu ekutapukira. Daklinza akanga ari wokutanga-anoshanda maitiro antiviral anokwanisa kubata genotype 3 pasina kuwedzerwa peginterferon kana ribavirin . Daklinza inotorwa pamwe chete neSovaldi kamwe zuva nezuva kana kuti pasina kudya kwemavhiki gumi nemaviri.

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Technivie

Yakagamuchirwa munaJuly 2015, Technivie (ombitasvir, paritaprevir / ritonavir) inoshandiswa mushonga unobatanidza kurapa vanhu vane genotype 4 utachiona. Vatatu vezvinodhaka zvinodhaka izvo zvinosanganisira Technivie zvinowanikwa muviri-pill bundle, Viekira Pak . Iko rinorayirwa kuyerwa mapiritsi maviri anotorwa kaviri zuva rimwe nerimwe ne ribavirin kwevhiki gumi nembiri.

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Viekira Pak

Yakagamuchirwa muna December 2014, Viekira Pak inonzi co-packaged drug therapy inoshandiswa kurapa hepatitis C chimiro chekuita utachiona kana pasina cirrhosis. Iko rinosanganisira chirongwa cheTranspnivie chakabatanidzwa pamwe chete nedzimwe chirwere chinonzi dasabuvir. Nhamba yakarongedzwa ndiyo mahwendefa maviri eTechnvie anotorwa kamwe chete zuva rega rega nechingwa uye imwe piritsi ye dasabuvir inotorwa kaviri zuva nezuva nezvokudya. Nguva yekurapa inobva mavhiki 12 kusvika ku24.

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Harvoni

Yakagamuchirwa munaOctober 2014, Harvoni (ledipasvir, sofosbuvir) inoshandiswa-inoshandiswa inoshandiswa mushonga inoshandiswa kurapa genotype 1 uye 4 kutapurirana kana kuti pasina cirrhosis. Inogonawo kushandiswa mune dzimwe mamiriro ejenotype 3. Harvoni yaiva yekutanga, yose-in-one mishonga yekugadzira mishonga iyo haina kudikanwa co-administration ne peginterferon kana ribavirin. Nhamba yakarongedzwa iyo imwe tablet inotorwa zuva rimwe nerimwe kana kuti isina zvokudya. Nguva yekurapa inobva mavhiki 12 kusvika ku24.

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Sovaldi

Yakagamuchirwa munaDecember 2013, Sovaldi (sofosbuvir) inoratidzira-inoshanda mishonga inorwisa maitiro anoshandiswa kurapa genotype 1, 2, 3 uye 4. Inotenderwa imwe yehwendefa yezuva rimwe nerimwe inotorwa pamwe kana pasina kudya. Zvichienderana nejenotype, ribavirin inogona kuiswa muchirapa. Kune genotype 3 utachiona, Sovaldi inobatanidzwa pamwe naDadlinza. Nguva yekurapa inobva mavhiki 12 kusvika ku24.

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Olysio

Yakagamuchirwa munaNovember 2013, Olysio (simeprevir) inonzi protease inhibitor-class drug inoshandiswa mukubatanidza kurapa kurapa vanhu vane hepatitis C maitiro ekutapukira 1. Olysio inoshandiswa mukubatana pamwe nepginterferon uye ribavirin kwemaawa makumi maviri nemasere kusvika makumi matatu. Nhamba yakarongedzwa imwe yehwendefa inotorwa zuva nezuva nechingwa.

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