Chii Chinoita Kuti Chisiyane?
Zorvolex inorwara-dose, inokurumidza-kuparadza fomu ye diclofenac, yeNSAID (nonsteroidal anti-inflammatory drug). Yakagamuchirwa kuitira kurapwa kwehutano hwe osteoarthritis muna 2014. Chii chinoita kuti chakasiyana nedzimwe mhando dzeDiclofenac nedzimwe NSAID?
Zorvolex, yakagadzirwa naIroko Pharmaceuticals, LLC, yakambotenderwa kuti irapwe kunyorova kusvika pakuenzanisa kurwadziwa kwakanyanya kune vanhu vakuru.
Kugamuchirwa kwehutano hwehasteoarthritis chiratidzo chinowedzera, Sezvo kwete mishonga yose uye mishonga inobatsira zvakaenzana kune chero munhu akapiwa, yakagamuchirwa senzira itsva yevarwere vetsva.
Mitauro yeDiclofenac
Zorvolex yakasiyana zvakadini ne generic diclofenac uye fomu yezita rainzi, Voltaren , iyo inonzi diclofenac, uye generic diclofenac? Zorvolex yakagadzirwa ne submicron particles ye diclofenac. Iyo submicron particles inenge ka20 pfupi zvishoma kudarika uhu hunoonekwa mune imwe mishonga inonzi diclofenac. Iyo submicron particles, yakashandiswa uchishandiswa SoluMatrix Fine Particle Technology, inobvumira kuti mishonga yacho iparadze nokukurumidza. Zorvolex ndiyo inotanga kushandiswa neNSAID (nonsteroidal anti-inflammatory drug) yakashandiswa uchishandisa SoluMatrix Fine Particle Technology iyo yakagamuchirwa neDFA.
Zvinoda Kubhadhara-Dose NSAIDs
Nhamba yakaderera NSAID inobatsira kutarisa mazano eDAA uye mazano.
Makore anoverengeka adarika, FDA yakarongedzwa uye yakawedzerwa kunyeverwa kwezvose zvinodhaka zveNSAID. Zvakanyatsotsanangurwa kuti NSAIDs dzinobatanidzwa nehuwandu hwehutano hwehutano hwemwoyo (semuenzaniso, kurwisa kwemwoyo uye kurohwa) uye zvinogona kuuraya kufa kwepamuviri ropa . Munenge nguva iyoyo, maviri COX-2 anosarudza NSAIDs - Vioxx (rofecoxib) uye Bextra (valdecoxib) - vakabviswa kubva pamusika, asi vazhinji vakaramba.
Dhiyabhorosi akaudzawo vanachiremba kuti vauye (uye varwere kuti vashandise) iyo miviri yakaderera yeNSAID yenguva shoma shoma inogona kuitika, ichifungisisa chinangwa chekurapa.
Kutarisa / Dosage
Nhamba yakakurudzirwa yeZorvolex (inodhaka mishonga) yehutano hwehasteoarthritis ndeye 35 mg. katatu pazuva. (Cherechedza: Zorvolex capsules haisi kushandurana neVoltaren kana kuti generic diclofenac mapiritsi.Dhesi uye simba hazvina kufanana.) Zorvolex 35 mg. iri bhuruu uye ruvara rwemapupa rine IP-204 rakanyorwa pamuviri uye 35 mg muhomwe muchena nyeki.
Kutora Zorvolex nechikafu kunogona kuderedza kubudirira - haina kumbobvunzwa. Uyezve, varwere vane chirwere chinonzi hepatic (chiropa) chinogona kudikanwa kuchinjwa kweiyo.
Zvinowanzovhiringidza Kuchinja
Kubva pamakiriniki ekuedzwa, zviitiko zvinowanzovhiringidzika zvinowanzobatanidzwa neZorvolex zvinosanganisira edema, nekushushikana, musoro, chizuru, kusuruvara, kuvimbiswa, kuvhara, kurwiswa, flatulence, kurwadziwa mumagumo, kurwadziwa mumimba, sinusitis, kuwedzera ALT (alanine aminotransferase), kuwedzerwa ropa creatinine, hypertension, uye indigestion.
Contraindications
Varwere vasingafaniri kutora Zorvolex vanosanganisira: avo vane hypersensitivity vanozivikanwa kuti diclofenac; varwere vane chirwere chemafi, mikoko, kana chero ipi zvayo inogadziriswa mushure mekutora aspirin kana chero NSAID; uye avo vane marwadzo anowanikwa neuronary artery kupfurikidza nekuvhiyiwa kwekufambisa.
Manyevero uye Kuchengetedza
Iyo inowanzonyeverwa inosanganiswa nemamwe ose NSAIDs, maererano nehuwandu hwehutachiona hwezviitiko zvemoyo nemakumbo ekuronda uye kubuda ropa, zvinoshandawo kuZorvolex. Kuchenjerera kunofanira kushandiswa kana varwere vane nhoroondo yekare yemaronda emimba kana kubuda ropa vanorayirwa Zorvolex. Ropa kuedzwa kwechiropa basa rinofanira kuitwa nguva nenguva kuti riongorore kusakanganisika. Varwere vanotora Zorvolex vanofanirawo kuongororwa nokuda kwehutano hwehutachiona, kuchengetedza kwemvura, dema, uye zvepfungwa . Anaphylactoid uye zvakanyanya kugadzirwa kweganda zvinogonawo.
Zorvolex haafaniri kutorwa ne aspirin sezvo kuita kudaro kwaizowedzera dambudziko rekudzivirira kwepachiviri.
Saizvozvowo, Zorvolex haafaniri kutorwa ne anticoagulants nekuti iyo inogona kuwedzera dambudziko. Kana uchitotora ACE inhibitor, diuretic, lithium, cyclosporine, kana methotrexate , kurangarirwa kunofanira kushandiswa nokuti kushamwaridzana kwezvinodhaka kunogona kuitika.
Kune vakadzi vane pamuviri, zvidzidzo zvemhuka zvakaratidza kuti Zorvolex inogona kukonzera kukuvadza kumucheche. Mushure memavhiki makumi matatu ekuberekwa, mushonga haufaniri kutorwa. Zvidzidzo zvakare zvakaratidza kuti mishonga inogona kuwanika mumukaka wemunhu wevanamukoti.
> Sources:
> Kunyora Mashoko. Zorvolex. Yakabudiswa muna August 2014.
> FDA Inobvumira Zorvolex Kuchipatara kweOsteoarthritis Pain. HCPLive. August 25, 2014.