Interferon imishonga inoita seprotini mumuviri iyo maitiro ezvirwere zvemuviri anoshandisa kuparadza mavairusi. Pegylated interferon ndiyo fomu yakashandurwa yemishonga inokwanisa kugara mumuviri kwenguva refu, inopa kurapa kwakanakisisa. Polyethylene glycol (PEG) yakawedzerwa kune interferon, chirongwa chinonzi pegylation, chinoshandiswa nemamwe marudzi emishonga pamwe chete.
Mhando mbiri dze pegylated interferons dzinowanikwa uye dzinoshandiswa kurapa utachiona hwaHepatitis C.
- Peginterferon alfa-2a: Inonziwo alfa-2a, zita rekutengeserana Pegasys.
- Peginterferon alfa-2b: Inonziwo alfa-2b, zita rekutengeserana PegIntron.
Vaionekwa sekusarudzwa kwesarudzo, yakashandiswa ne ribavirin, uye yakanyorwa muWorld Health Organization's List of Essential Medicines. Kurapa kweHCV kuri kuchinja nekugamuchirwa kweSofosbuvir (Sovaldi) uye Simeprevir (Olysio) muna 2013 neDFA. Iyi mishonga mitsva uye vamwe chokwadi chekutevera inogona kushandura zvinotapurirwa sechirongwa chinosarudzwa.
Mhedzisiro huru pakati peizii idzi pegylated interferons iri mu dosing. Alfa-2a inoshandiswa sehora rakagadzirirwa vhiki imwe neimwe. Alfa-2b inoshandiswa senhamba yevhiki nevhiki inobva pauremu hwomurwere. Kune dzimwe misiyano pakati pemishonga mbiri, asi iyo inonyanya kushandiswa uye inoshandiswa nekurapa chiremba .
Semuenzaniso, alfa-2a inogadziriswa nguva dzose mushure mejojo uye inowanzoparadzirwa muropa uye nhengo. Asi alfa-2b ine kuwedzerwa nokukurumidza uye kugoverwa kwakakura mumuviri.
Kusiyana Mukubudirira
Kusvikira munaJanuary 2008, hapana dheta zvakananga kuenzanisa mishonga iyi miviri. Izvozvo zvakashandurwa nechirongwa chekuchirapa chikuru chinonzi IDEAL uyezve mamwe makiriniki kufananidza.
Izvi zvinopa migumisiro inofadza iyo inobvumira vanachiremba kuti vawedzere kunzwisisa pamusoro pemasimba aya ane simba anonzi hepatitis C therapies .
Chirongwa chekudzidzira - Dhiyabhorosi Duty Efficacy maererano neDisposition Dating kuongorora Optimal Pegylated Interferon Therapy - inobatanidza 3070 vanhu mumutambo unotungamirirwa nemaitiro. Yakawana kubudirira kwakadaro pakati pearfa-2a ne-alfa-2b mukusimudzira virological response rate . Alfa-2a aive nechiyero che 41% uye alfa-2b aiva neSVR ye39%.
Asi nyaya yacho haina kuvharwa. Zvimwe zvidzidzo zviviri zvakawanikwa zvakasiyana-siyana zvakasiyana pakati pemishonga mbiri, ine alfa-2a kukunda zvakajeka nevanopfuura 12% muhutano hwakanaka muSVR.
Imwe meta-analysis yevane 3518 varwere kubva mumatambudziko manomwe anorongedzwa akachengetedzwa vakawana migumisiro yakanaka kune alfa-2a, kunyange zvazvo yakabudisa huwandu hwehuwandu hweutachiona. Neutropenia inoderedza kuwanda kwemasero machena eropa. Ichi chinhu chinogadzirisa chikamu chisingadikanwi, semasero matsvuku eropa ndiyo chikamu chikuru chemuviri wemuviri wemuviri. Kana ichingoderedzwa, iwe unenge uine hutachiwana hwehutachiwana uye unogona kukwanisa kurwisa mabhakitiriya nemavirusi.
Izvi zvinoguma zvichange zvichinyatsofungidzirwa apo kurumbidza kurapwa. Asi mishonga mitsva inogona kushandura mapepa ekufambisa sekurapa kusarudzwa kwechirwere chechipatara C.
Izvozvo ndizvo zvakaita kutsvakurudza uye kubudirira. Izvozvo zvingaguma zvave zvisinganzwisisiki kuenzanisa mishonga iyi miviri semishonga matsva ichave yakasarudzwa.
Sources:
Berenguer M, Wright TL. Hepatitis C. Mu: M Feldman, LS Friedman, LJ Brandt (eds), Maviri uye Chirwere Chirwere, 8e . Philadelphia, Elsevier, 2006. 1701.
Hepatitis C Mibvunzo yeZvipatara, Gumiguru 14, 2015. Nzvimbo dzeDaase Control uye Kudzivirira
McHutchison JG, Lawitz EJ, Shiffman ML, Muir AJ, Galler GW, McCone J, Nyberg LM, Lee WM, Ghalib RH, Schiff ER, Galati JS, Bacon BR, Davis MN, Mukhopadhyay P, Koury K, Noviello S, Pedicone LD , Brass CA, Albrecht JK, Sulkowski MS, IDEAL Chikwata Chekudzidza. Peginterferon alfa-2b kana alfa-2a ne ribavirin kurapwa kwehutachiona hweH hepatitis C. N Engl J Med. 2009; 361 (6): 580-93.
Rumi MG, Aghemo A, Prati GM, D'Ambrosio R, Donato MF, Soffredini R, Del Ninno E, Russo A, Colombo M. Randomized chidzidzo che peginterferon-alpha2a pamwe ribavirin vs peginterferon-alpha2b plus ribavirin mune chirwere chisingarapiki hepatitis C. Gastroenterology . 2010; 138 (1): 108-15.
Ascione A, De Luca M, Tartaglione MT, Lampasi F, Di Costanzo GG, Lanza AG, Picciotto FP, Marino-Marsilia G, Fontanella L, Leandro G. Peginterferon alfa-2a uye ribavirin inoshanda kupfuura peginterferon alfa-2b plus ribavirin yokurapa utachiona husingaperi hwehutachiona hweH hepatitis C. Gastroenterology . 2010; 138 (1): 116-22.
Alavian SM, Behnava B, Tabatabaei SV. Kuenzanisa kushanda uye kuchengeteka kwepinterferferon alpha-2a vs 2b mukurapa kwekusingaperi HCV chirwere: meta-analysis. Hepat Mon. 2010; 10 (2): 121-31.