Zviratidzo, Njodzi Dambudziko, uye Kuongororwa kweCTE
Pane kuwedzera kukura pakati pechiremba kuti matambudziko akawanikwa mushure mekukuvadzwa kwepamusoro haakurumidze kugadzirisa. Izvi ndezvechokwadi kunyanya kune vanhu vane makuvadza akawanda emusoro, kunyanya vatambi vari mumitambo yekubatana nevasungwa.
Kukuvadzwa Kwemusoro Kunotungamirira kuCTE
Hapana kukuvadzwa kukuru kwemukoko kunodiwa. Kusuruvara kwakakuvara kwehuropi (mTBI) kana kunyange kukuvara kwemadiki musoro zvishoma kunogona kupa.
Mushure mekugadzirisa, vamwe vanhu vanotambura ne -post-concussive syndrome (PCS) yekunyunyuta , kuora musoro , uye kuvhiringidzika. Asi CTE inopfuura kungove kwenguva yakareba ye post-concussive syndrome-inoitika makore gare gare, kusiyana neCCS, iyo inowanzouya pfupi pfupi mushure mekukuvadzwa kwemukoko.
Zvimwe Ngozi dzeCTE
Kunyange zvazvo CTE yakasiyana zvikuru nechirwere cheAlzheimer munzira dzakawanda, inogona kugoverana nehutachiona hunokonzera. ApoE4 ndiyo inonyanya kuzivikanwa nezvehutachiona hwehutachiona hwekupedzisira-kutanga kweAlzheimer's. Vanhu vane ApoE4 mutations zvakare vakaratidzirwa kuti vane nguva refu yekudzikinura kubva mukukuvara kwemukoko, uye kukanganiswa kwakanyanya pashure pekukuvara kweimwe musoro. Zvisinei, zvimwe zvidzidzo zvakaratidza kuti hapachina hukama pakati peCTE neApoE4. Kutsvakurudza kwakawanda mune izvi zvinogona kuwirirana kunodiwa.
Vakadzi vanoita kunge vane nguva yakareba yekudzikinura kubva kumakwikwi kupfuura varume, asi hazvizivikanwe kana izvi zvinotungamirira kune ngozi yakasiyana yekukudziridza CTE.
Uzhinji hwehutano hwakadzidzwa neCTE hwave huchiri murume nekuda kwekuwanda kwevatambi vechikwata kana varwi vehondo. Uropi hunochinja hunoenderana neCTE hwave huchiwanika kunyange kune vanhu vaduku zvikuru vane maitiro akawanda emusoro, asi kuchinja kunowedzera kukura nezera.
Kuziva
Zvepamutemo zvinogara zvisingagadziriswi encephalopathy (CTE) zvinogona kuongororwa ne autopsy.
Zvimwe mapuroteni, akadai se tau uye TDP-43, inowedzera muuropi. Izvi zvakasiyana nechirwere cheAlzheimer, chinoratidza beta-amyloid plaques, iyo iripo pasi pehafu yezviitiko neCTE. Uyezve, kuchinja kwekutanga kunowanikwa kune mitsara yeropa.
Pasinei nechokupedzisira chido chekusimbiswa ne autopsy, pane zviratidzo zvinonyanya kuratidza zveCTE, kusanganisira zvinotevera:
- kukanganiswa kwepfungwa
- kuderedza simba rekuita zvisarudzo
- kusaruramisira
- kusafarira
- kushayiwa simba nekudzivirira
- utsinye
- kuora mwoyo uye kuzviuraya
Mukuwedzera, kune zvimwe zviratidzo zvenyama zveCTE zvinogona kuvapo, kusanganisira:
- kuoma nekuenzanisa uye kufamba
- Yakaderera, kutaura kwakanyarara
- Parkinsonism (kudengenyeka, kusagadzikana, uye kunonoka kufamba)
Panewo kamudiki kadiki yevarwere vane CTE avo vane chirwere chisingaperi chinonzi encephalometepathy (CTEM). Ichi chirwere chinomiririra zviratidzo zvehosha yaLou Gehrig (ALS) , ine urombo husina simba uye kuparara, kunetseka kubvumira, uye kushaya mafungiro akaipa.
Gare gare muchikwata cheCTE, varwere vachabatwa nekutemwa kwemagumisiro. Panzvimbo pechirwere cheAlzheimer, zviratidzo zvekugara kwenguva refu zvinokonzera kushungurudzika zvakanyanya kufanana nemafambiro akasiyana-siyana ekutenderera mberi kweropa (bvFTD).
Zvisinei, CTE kazhinji inouya pfupi zvishoma kupfuura bvFTD, pakati pemakore makumi matatu kusvika makumi mashanu pane makore makumi maviri kusvika kune makumi mashanu nematanhatu. Maitiro akasiyana-siyana anonzi frontotemporal dementia anowanzofambira mberi nekukurumidza kupfuura CTE, uye kazhinji ane ruzivo rwechimiro icho CTE haiti.
Migumisiro paBongo
Iko kunoderedzwa uropi huremu uye kuponda kwe corpus callosum, iyo inobatanidza uropi huviri humispheres.
Kunewo nguva yakawanda inrophy ye frontal lobes muCTE. Izvo zvakashata zvinoshandisa mano edu ekuita zvisarudzo zvakanaka uye kuronga, uyewo kutitendera kuti tigadzirise zviyeuchidzo.
Dzimwe nzvimbo dzakakanganiswa dzouropi dzinosanganisira miviri yemammillary uye hippocampus, iyo inobatanidzwa neyekuyeuka, pamwe chete ne substantia nigra, iyo inobatanidzwa nekufamba.
Kuedzwa kweCTE
Kunyange zvazvo vanhu vakawanda vachiziva nezveCTE yakakura nokukurumidza munguva pfupi yapfuura, sayenzi inowanzoterera kukura miedzo inonyanya kudikanwa. MRI inogona kubatsira kutonga dzimwe zvirwere, uye inogona kuratidzira kuparara kusinganzwisisiki kweamygdala, iyo inogona kukurudzira CTE sekuongororwa. Mamwe maitiro eimwe kuedza akadai seMRI anoshanda ari kuongororawo.
CTE Treatment
Hapana hutano hunowanikwa hweCTE kana hwave hwakagadzirwa. Sezvinowanzova zvakadaro, kudzivirira ndiyo mishonga yakanakisisa.
Kudzivirira Kunokosha
Chido chekuchengeteka tsika mumitambo uye hupenyu hwose huri kuwedzera kusimbiswa. Vatambi vanofanirwa kukurudzirwa kuti vataure kana vari kutambura nemigumisiro yekukuvadzwa kwepamusoro, uye kutevera mitemo yekudzoka kutamba mushure mekukuvara kwakadaro. Ndiyowo basa revanodzidzisa kudzidzisa vatambi vavo nzira dzakarurama dzekudzivirira pachedu. Zvakanaka kutamba zvakaoma, asi zvakakosha zvikuru kutamba wakachengeteka.
> Sources:
> Baugh, CM, et al. (2012). Chronic traumatic encephalopathy: neurodegeneration inotevera kudzokorora concussive uye subconcussive brain trauma. Kufananidza Ubongo uye Maitiro, 6 (2): 244-54.
> Saulle, M., & Greenwald, BD (2012). Chronic traumatic encephalopathy: kuongorora. Ongororo Yokugadziriswa uye Kuita, 816069. Epub 2012 Apr 10.
> Shively, S., Scher, AI, Perl, DP, & Diaz-Arrastia, R. (2012). Dhementia Inokonzera Kubva Kunetseka Bongo Kukuvadza: Chii Chinonzi Pathology? Archives of Neurology, Jul 9: 1-7.