Beta Amyloid Protein, Plaque, uye Alzheimer's

Beta-amyloid protein uye mapepa - aya ndiwo mazwi maviri anowirirana neuropi hunochinja muhosha yeAlzheimer. Unoda kuziva zvakawanda here? Heano zvinhu zvizere 9 kwamuri:

1. Izvo zvinokonzerwa neBeta-amyloid protein muuropi inoonekwa seimwe yezviratidzo zvechirwere cheAlzheimer . (Chimwe chinonyanya kuzivikanwa ndezvemapapiro eurofibrillary .) Izvi mapuroteni e-beta-amyloid anoungana pamwe chete kuti aite insoluble (asingakwanisi kuputswa) mapeji kunze kweeuroni.

1. Beta-amyloid mapuroteni anovakawo pa synapses uye anopesana nekukurukurirana kubva kune imwe sero kuenda kune imwe muuropi.
2. Pamberi pemasumbu e beta-amyloid yakakura zvokuti inonzi " plaque ," mapuroteni aya anotanga kuumba oligomers . Oligomers achiri kusanganiswa (anokwanisa kuparara), madiki maduku e beta-amyloid.
3. Kunyange zvazvo zvirongwa zvave zvichizivikanwa sechimwe chezvikonzero zvinokonzerwa neAlzheimer's, vatsvakurudzi vachangobva kutaura izvi mubvunzo, kuzivisa oligomeri anotsanangurwa pamusoro apa sekuti ari imwe yenzira huru mukudzivisa kutaurirana kubva pane imwe sero kusvika kune imwe. Chimwe chikonzero chiri shure kweizvi ndechekuti vamwe vanhu vane plaque kuvaka-up muuropi, asi havana zviratidzo zvehosha yeAlzheimer .
4. Uyezve, kumwe kutsvakurudza kwakaratidza kuti kuchinja kwepfungwa kunotanga kutanga kusati kwaitika mapuroteni e-bety-amyloid kubva pamakona makuru emucheka.
5. Sayenzi yakawana beta-amyloid mapuroteni makore anopfuura zana apfuura. Vakatanga kuonekwa naDkt. Alois Alzheimer muna 1906.

1. Beta-amyloid chikamu cheprotein yakakura inonzi amyloid precursor protein .
2. Nhamba inofadza: "Masayendisiti mazhinji anofungawo kuti mapepa angangodaro ari kuedza kwekupedzisira-yesero yeuropi kuwana iyi inokuvadza beta-amyloid kure neuron" (Alzheimer's Disease Education and Referral Center).
3. Kutsvakurudza kwakaitwa paUC Davis Alzheimer's Disease Center yakawana kuti maitiro ezvirwere zvezvirwere anopindura nenzira imwecheteyo kuisa sezvakaitwa kubhakitiriya, zvichikonzera kuputika muuropi iyo yakakanganisa neurons. Kuvhiringidza muuropi kwakabatanidzwa nechirwere cheAlzheimer.

Sources:

_{Alzheimer's Association. Ongororo yeAlzheimer Drugs Targeting Beta-Amyloid uye "Amyloid Hypothesis." 2008.}

_{Alzheimer's Association. Zvimwe Pamusoro Pamakwenzi.}

_{The DANA Foundation. Amyloid-Beta 'Oligomers' Inogona Kubatana neAlzheimer's Dementia. July 12, 2010.}

_{National Institute of Aging. Dambudziko reAlzheimer Education and Referral Center. January 22, 2015.}

_{Stanford Medicine. Masayendisiti Anoratidzira Sei Beta-Amyloid May Angaita Alzheimer's. Svondo 2013.}

_{UC Davis Health System. Alzheimer's-causing Amyloid and Bacteria Trigger Same Immune Response.}