Chirwere cheAlzheimer chirwere chinokanganisa cheuropi. Kunzwisisa kuti kutarisa kweAlzheimer kwakasiyana sei neuropi yakakwana kunotipa kunzwisisa. Inogona kutibatsira kukunda zviri nani nekuchinja kunoitika kune vadikanwa vedu semugumisiro wechirwere ichi chinoparadza.
Muhosha yeAlzheimer , kuonekwa kwehutano hweAlzheimer hunosiyana zvikuru nehutano hwehutano.
The cerebral cortex atrophies. Izvozvo zvinoreva kuti nzvimbo iyi yeuropi inodonha uye uku kunamatira kunoshamisa zvakasiyana kubva kune cerebral cortex yehutano hwakakwana. Iko inonzi cerebral cortex inzvimbo yekunze kweuropi. Icho chinokonzera kushanda kwepfungwa dzose. Pano pane kuchinja kukuru kwezvinhu zvinogona kuonekwa muuropi pazvinyorwa:
- Uwandu hwehuropi huri muhutano hwehuropi (gyri) hwakaderera
- Nzvimbo dziri mumakumbo europi (sulci) dzakanyanya kuwedzerwa.
Microscopically kune huwandu hwekuchinja muuropi zvakare.
Tsanangudzo mbiri mbiri muhutano hweAlzheimer ndiwo amyloid plaques uye matumbo eurofibrillary. Amadholoid plaques anowanikwa panze neurons, neurofibrillary plaques anowanikwa mukati meeuroni. Neurons ndiyo masero emutsipa mukati meuropi.
Mabhandi nematambi zvinowanikwa muhupenzi hwevanhu vasina Alzheimer's. Izvo zviyero zvakawandisa zvevari zvakakosha muAlzheimer's disease.
Basa reAmiloid Plaques
Amyloid plaques inowanzogadzirwa neprotheni inonzi B-amyloid protein iyo iyo pachayo inhengo yeprotein yakakura zvikuru inonzi APP (amyloid precursor protein). Izvi ndizvo amino acids.
Hatizivi kuti APP inodini. Asi isu tinoziva kuti APP inogadzirwa muchitokisi, inotakurudzirwa kune kamuri memira uye gare gare yakaputsika pasi.
Nzira mbiri mbiri dzinobatanidzwa mukuparara kwe APP (amyloid precursor protein). Imwe nzira inofanirwa uye inokonzera kusava nechinetso. Yechipiri inoguma mukushandurwa kunoonekwa muAlzheimer uye mune imwe yerimwe pfungwa.
Kuparara Kunzira Kunotungamirira Kukuvara kweAlzheimer
Muchikamu chechipiri kuputsika APP inoparadzaniswa ne enzyme B-secretase (B = beta) uye y-secretase (y = gamma). Zvimwe zvezvimedu (zvinonzi peptides) zvinoguma pamwe pamwe uye zvinogadzira ketheni shomanana inonzi oligomer. Oligomers anozivikanwawo seAdDL, amyloid-beta yakagadziriswa yakajeka ligands. Oligomers of amyloid beta 42 vakaratidzirwa kuti vanokonzera matambudziko mukukurukurirana pakati peeurons. Amyloid beta 42 inoberekawo michina maduku, kana fibrils. Apo pavanonamatira pamwe chete vanoita chidimbu chema-amyloid. Zvimwe zvezvipande izvi zvinogona kuzviisa mu membrane ye-neuron cell inokonzera zvinhu kunze kwekamuri kuti ipinde mukati mayo, zvichiita kuti zvimwe zvikuvadze. Izvi zvinokonzera mujecha reAmyloid beta 42 peptidi inotungamirira ku neuron kusagadzikana nekufa.
Basa reMatambo eEurofibrillary
Chechipiri chinowanikwa muhutano hweAlzheimer ndechekutipa neurofibrillary. Matamba eurourofibrillary anoumbwa neprotheni inonzi tau protein.
Tau mapuroteni anoita basa rinokosha mukugadzikana kweeuron. Muvanhu vane mapuroteni eAlzheimer anoita kuti zvive zvisina kufanira kuburikidza nemakemikari anonyanya kushanda anokonzerwa nekuumbwa kwemakumbo eurofibrillary. Nyeredzi yeurourofibrillary inoguma nekufa kwemasero.
Bhuku reAlzheimer's Summary
Basa reamyloid plaques uye maratidzo eurofibrillary pamusoro pekushanda kweuropi hazvisi kunzwisiswa zvakakwana. Vanhu vazhinji vane chirwere cheAlzheimer vanoratidza uchapupu hwemadziro maviri nemakumbo, asi nhamba shomanana yevanhu vane Alzheimer chete vane mabandi uye vamwe vane neurofibrillary tangles chete.
Vanhu vane ruvara rweAlzheimer chete vanoratidzira zvishoma nezvishoma kuderera kwehupenyu hwavo.
Vanhu vane mavara eurofibrillary vanowanzoonekwa kuti vane foreotemoral dementia .
Kutsvakurudza muhutano hweAlzheimer kuwedzera kuwedzera pamusoro pemaitiro uye hutano hwehuropi. Sezvatinonzwisisa zvakawanda pamusoro pebasa remavara uye matanho anoonekwa muhutano hweAlzheimer apo tinoswedera pedyo nekugadzirisa kukuru uye kurapa kwechirwere cheAlzheimer.