Chii Chinonzi Bakterial Colonization?

Bhakteria Colonization yeMapukisi neCystic Fibrosis

Iwe ungangodaro wakanzwa nezvoutachiona hwekukanda kana iwe uri kurarama ne cystic fibrosis. Izvi zvinorevei?

Chii chinonzi Colonization?

Makoroni anoitika apo microorganisms inorarama kana mune imwe mhuka yakakura asi haipindi mishonga kana kukuvadza. Kukoloni kunoreva kuvapo kwezvirwere zvinogona kukonzera utachiona, asi kwete kuhutachiwana pachahwo.

Kuva nehutachiona huripo, zvisinei, hunowedzera hutachiwana hwehutachiona kana nzvimbo yakarurama yehutachiona hunoitika.

Kukosha kweKoloni muCystic Fibrosis

Vanhu vane cystic fibrosis (CF) vanowanzokanganiswa nemabhakitiriya, kunyanya mumucheka nemhepo. Kana zvipenyu zvinotanga kupinda mumasumbu uye zvichikonzera kukuvadza kana kuita kuti munhu arware, kukora kunova hutachiona.

Kufuridzirwa Kwetachiona Kuchinja Kwevanhu VaCystic Fibrosis

Mune vanhu vane cystic fibrosis, kuvharwa kwakanyanya kwehuputi uye hutachiona husingaperi hunokonzerwa nebhakitiriya hunokonzera chirwere chakakosha chokuvhara chirwere chepemmonic. Vanhu vane cystic fibrosis pakupedzisira vanoumba bronchiectasis umo mhepo inova yakaipa uye yakaora.

Bronchiectasis inzvimbo iyo mabhonchi uye bronchioles (matavi maduku emhepo) akawedzera, akawedzera uye akaora. Mucus inounganidza mune iyi mhepo yakakura yakaita kuti iwane zvirwere.

Utachiona hunoguma nekuwedzera kuwedzera, kuwedzera, uye kupora kwemhepo inoitazve kudzokorora kuipa.

Kunze kwebronchi uye bronchioles inonzi alveoli , iyo midzimu midzi midzi inoshandiswa kuchinjana kweokisijeni uye carbon dioxide. Apo mabhonchioles anotungamirira kune idzi zviduku zvikuru dzemhepo dzinorasikirwa nekudzikama kwepurasitiki (kubva pakusvikika uye kupera) uye kuva akavharwa nemucheka, oxygen inoputirwa mumapapu haigoni kusvika kune alveoli kuti kugoverana kwegesi kuitike.

Nei Mafungu Ari Muvanhu NeCystic Fibrosis Anobereka Mucus Yakawandisa?

Hazvinyatsonzwisisiki kana vanhu vane cystic fibrosis vepakutanga vachibudisa huputi hwemasciti yakawandisa kana kuti vanozviita nekuda kwebhakitiriya. Zvisinei, kuongororwa kwemapapu mumatangwana ane cystic fibrosis avo vasati vava kukonzerwa nemabhakitiriya inoratidza kukanganisa kwakawanda kwemukoko. Izvi zvitsva zvinoratidza kuti mhutu inotungamirira vanhu vane cystic fibrosis kuenda kukoloni nemaabhakitiriya.

Ndeapi maBhakiteriya Anokonzera Makomba Evanhu NeCystic Fibrosis?

Mhando dzakawanda dzebhakitiriya reaerobic (mabhakitiriya anokura mumusana weokisijeni), vanaerobic mabhakitiriya (mabhakitiriya anokura pasina oxygen) uye majekiseni anokonzerwa nemafungidzi anokonzera mapapu evanhu vane cystic fibrosis. Izwi rokuti zvirwere zvinokonzera kushandiswa zvinoshandiswa kurondedzera zvirwere zvisingaiti kazhinji zvinokonzera kutapurirwa mune vanhu vane utano asi zvinogona kukonzera kutapukira apo "mukana" unobuda, sekunge chirwere chemapapu chiripo.

Heano zvimwe zvipenyu zvinokonzera mapapu evanhu vane cystic fibrosis:

• Pseudomonas aeruginosa
• Staphylococcus aureus (kusanganisira MRSA )
• Escherichia coli
• Haemophilus influenzae
• Klebsiella
• Prevotella
• Propionibacterium
• Veillonella

• Aspergillus (dzidza nezvebroonchopulmonary aspergillosis kuvanhu vane cystic fibrosis)

Kazhinji Nyaya Yenhengo Dzakagadziriswa Ipi Iyo Colonize Airways muvanhu vane CF

Pamusoro pezvisikwa zviri pamusoro apa, kukonzera pamwe nePseudomonas kunowanzoita uye inenge 80 kubva muzana yevanhu vakuru vane cystic fibrosis inokonzerwa nemhando iyi yemaktheria.

Multidrug-Resistant Organisms neCystic Fibrosis

Mukuwedzera kune zvipembenene zvinoratidzwa pamusoro apa, vanhu vane cystic fibrosis vanowanzobatanidzwa ne "superbugs" kana zvirwere zvisingaverengeki . Zvisikwa zvakawanda zvinopesana nezvinokonzerwa nemishonga (zvipenyu zvinorwisana nemishonga yakawanda inorwisa mabhakitiriya) inobata mumapapu emunhu ane cystic fibrosis inogamuchira mishonga inorwisa mabhakitiriya yezvipembenene zvemapapu, zvakadai sePseudomonas.

Makoroni uye hutachiona nemararamiro asingaverengeki anotyisa nokuti zvipenyu izvi zvinorambidza kurapwa nemishonga inorwisa mabhakitiriya.

Sei Kutongwa Kwemakoloni NePseudomonas Kunotora?

Nyanzvi dzine pfungwa dzakawanda kana dzinofungidzira kuti sei mapapu evanhu ane cystic fibrosis inowanzobatanidzwa nePseudomonas, kusanganisira zvinotevera:

• Yakagadziriswa mucociliary clearance yakabatanidzwa nekushaya kushanda kwe antibacterial peptides
• Kusachengetedzwa kusina simba kwemapapu nemhaka yehutachire hwema glutathione uye nitrous oxide
• Yakapedzwa kuwedzerwa kwebhakitiriya nemasero emapapupa
• Nhamba yakawandisa yezvinyorwa zvebhakitiriya

Hatitombozivi kuti ndeipi nzira idzi dzinonyanya kukosha pakusimbisa kukorodzwa kwePseudomonas. Kunyange zvakadaro, zviri pachena kuti kana Pseudomonas inobata, chirwere chisingaperi chinopfuurira.

Vanhu vane cystic fibrosis vanobatanidzwa nePseudomonas vanoda chirongwa chekuchengetedza zuva rega rega uye nguva nenguva inorwisa inorwisa antibiotic therapy apo hutachiwana huripo. Nhamo, kunyange nekurapa kwakadai, chirwere chePseudomonas chinoguma nekurasikirwa kwemapapu uye chinotungamirira pakupedzisira kufa kune vanhu vazhinji ne cystic fibrosis. Dzidza zvakawanda pamusoro pePseudomonas mune vanhu vane cystic fibrosis .)

_Sources

_{Boutin, S., uye A. Dalpke. Kuwana uye Kugadziriswa kweAirway Microbiotia muHupenyu Hwekutanga hweCystic Fibrosis Varwere. Molecular and Cellular Pediatrics . 2017. 4 (1): 1.}

_{Huang, Y., uye J. LiPuma. The Microbiome muCystic Fibrosis. Clinical Chest Medicine . 2016. 37 (1): 59-67.}

_{Voynow JA, Mascarenhas M, Kelly A, Scanlin TF. Cystic Fibrosis. Mu: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack Pack AI, Senior RM, Siegel MD. eds. Fishman's Pulmonary Diseases and Disorders, Fifth Edition . New York, NY: McGraw-Hill; 2015.}