Pseudomonas Aeruginosa Inokosha Zvikuru Muvanhu Vane CF
Vanenge 60 muzana yevanhu vane cystic fibrosis vane chirwere chisingaperi chekufema chinokonzerwa nebhakitiriya rinonzi Pseudomonas aeruginosa. Iyi bhakitiriya inopinda mumucheka wakaoma wakabatwa mumhepo. Pane imwe Pseudomonas aeruginosa inopinda nenzira yekupemha, zvakaoma kubvisa. Kukundikana kwokuputika kunokonzerwa nehutachiona ndicho chinokonzera rufu muzhinji rwevanhu vane CF.
Bhakitiriya Pseudomonas aeruginosa anorarama matipoteredza. Iyi bhakitiriya iripo munzvimbo dzakanyorova dzakadai sedzakatenderedza ivhu, zvinomera, kunyura, mvura inopisa uye kunyange zvigaro zvehombodo dzetiza. Vanhu vazhinji vanosangana nePseudomonas aeruginosa zuva rimwe nerimwe vasina kutapukirwa. Zvisinei, kune vanhu vasingazivikanwi kana kuti vane vanhu vane ganda reganda kana mutsara, izvi zvinokonzera utachiona.
Mukuwedzera pakubata vanhu vane CF, Pseudomonas aeruginosa infects zvakanyanya kupisa varwere pamwe nevarwere vanowana chemotherapy . Mumakore achangopfuura, chiitiko chePseudomonas aeruginosa chirwere nemhaka yezvikonzero kunze kweCF yakaderera; asi, chiitiko chekutapukirwa pakati pevanhu vane CF chakaramba chisina kuchinja.
Pseudomonas Aeruginosa Anoitwa Sei?
Makore apfuura, kusingaperi Pseudomonas aeruginosa hutachiona muvanhu vane CF yaibatwa zvisina kufanira nemishonga inorwisa mishonga kana kuti inhaled injectable formulations ye antibiotics .
Mukupera kwema1991 maitiro ehutachiona hwemishonga inoramicrobira tobramycin, kana TOBI, yakagadzirirwa zvakananga kurapwa kwechirwere chisingaperi chepseudomonas aeruginosa zvirwere. TOBI iye zvino ndiyo inoshandiswa kurapwa kwechirwere ichi uye inowanzotaurwa nemishonga kune vanhu vane cystic fibrosis.
Chii Chinonzi TOBI?
TOBI yakaumbwa ne tobramycin. Tobramycin inonzi antibiotic aminoglycoside inoshandiswa kubata chirwere chePseudomonas aeruginosa. Iyi antibiotic inoshanda nekushambadza neprotiniti yepiriniti synthesis. Nokushambadzira neprotheni yePseudomonas aeruginosa, TOBI inokonzera kukanganisa bhakitiriya se membrane uye iyo envelope zvichiita kuti sero kufa.
Chii chinonzi TOBI Podhaler?
TOBI yakatanga kushandiswa kushandisa nebulizer . A nebulizer mishonga inobereka mhepo yakanaka yekuputira. Muna 2013, FDA yakabvumira TOBI Podhaler, iyo yakaoma poda inhaler yakazadzwa nehupfu hwakatsetseka tobramycin. Iyi mushonga mutsva inoita kuti zvive nyore kumurwere kutora tobramycin
Inonzi TOBI kune Wese?
Nhamo, TOBI haisi yevanhu vose. Vanhu vane zvinetso zvekunzwa, matambudziko eminyo, uye matambudziko e-neuromuscular anofanirwa kunyorerwa TOBI kunyatsochenjerera. Kunyanya zvakanyanya, aminoglycosides inozivikanwa kuti inoputika nekunzwa, itsvo pamwe nekuwedzeredza chirwere chendaneti chinonzi myasthenia gravis. Uyezve, vanhu vane hypersensitive ("allergic") kune aminoglycosides havafaniri kutora TOBI. Pakupedzisira, tobramycin, iyo inoshandiswa inoshandiswa muTVB, inotatogen uye inogona kukonzera kukuvadza kumucheche muvakadzi vane pamuviri.
Kunobva:
Smith, AL "Inhaled Antibiotic Therapy: Ndeipi Mishonga? Ndeipi Dose? What Regimen? Chii Chinogadzirwa? " Journal of Cystic Fibrosis . 2002 1: S189-S193. 22 June 2008.
Ramphal R. Infections Pamusana pePseudomonas Species uye Related Organisms. Muna: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. eds. Harrison's Principles of Internal Medicine, 19e . New York, NY: McGraw-Hill; 2015.