Varwere Vanofanira Kushandisa Kufunga Kunokosha Paunenge Uchiverenga NeBD Research
Kutsvakurudza kune zvikonzero zvinokonzera kupisa zvirwere (IBD) zvakakosha, zvinodiwa, uye zvinodiwa. Nekutsvakurudza kwehutano, masayendisiti achakwanisa kuwana mamwe mazano pamusoro pezvinovhiringidza IBD uye kuti ungazviita zvakadini. Zvisinei, kwete mapeji ose ekutsvakurudza nezveBD ndeyekubudirira. Zvechokwadi, kwete mapepa ose ekutsvakurudza anoita seanovimbisa pakutanga kana mhepo inotungamirira kune kuwanikwa kunokosha pamusoro peBD gare gare.
Pane imwe nzira yakareba vasati vatsva zvinoshamisa zvinowanikwa nevatsvakurudzi vanogona kuva chinhu chinogona kushandiswa navanachiremba kubatsira varwere kana nemakambani ekurapa kuita mushonga. Mamwe masayendisiti nevatsvakurudzi vanofanira kudzidza mhinduro dzekutanga uye vanogona kuita imwe dzidzo uye kuwana mhinduro imwe chete.
Apo vanotsvakurudza vanofungidzira kuti vanogona kuwana chimwe chinhu chakakosha, vanogadzira uye vanoita zvidzidzo zviduku. Kana icho chidzidzo chinoratidza chimwe chinhu chakakosha, zvidzidzo zvikurusa zvinoitwa. Ari munzira, zvinogona kuwanikwa kuti zvidzidzo zvakakura hazvive nemugumisiro mumwe chete wekuti zvidzidzo zviduku zvakaitwa. Panguva iyoyo, kumwe kuongorora kunoda kuitwa kuti uone zvakaitika pakati pezvidzidzo zviviri uye nei vasingafanane. Apo kutsvakurudza hakusimudzi kuve kwakakosha sekufunga kwekutanga, zvinonyadzisa kune vatsvakurudzi, vanachiremba, uye vanhu vane IBD.
Muenzaniso Wokutanga Ongororo
Masayendisiti ave achiziva kwenguva yakati kuti maitiro evanhu vane Crohn's disease uye ulcerative colitis ine zviyero zvakasiyana zvebhakitiriya uye mapuroteni kupfuura vanhu vasina IBD.
Kuziva kuti maitiro ezviri mukati megomba zvakasiyana zvechokwadi anovhiringidza ruzivo mberi uye anobatsira vatsvakurudzi kuderedza zvidzidzo zvekutevera.
Zvakakosha, zvisinei, kuziva zvakajeka kuti kuva nezvirwere zvakanyanya kana zvishoma kana zvishoma pasi mapuroteni zvinoreva muchirongwa chikuru chezvinhu. Iyo IBD inokonzera kuti kuchinja uku kuitike here?
Kana kuti kuchinja uku kunouya nekuda kweimwe chikonzero here? Iko kuchinja uku kunobatanidza sei nezvinokonzera IBD? Pane pfungwa pamusoro pezvinenge zvese izvi zvinorevei, asi isu tisati taziva mhinduro dzemibvunzo iyi zvechokwadi.
Mumwe muenzaniso wakakwana wekutsvakurudza kwepakutanga ndedzidzo ye 2016 yakabudiswa mumagazini mBio iyo yakadzidza zvipenyu mumvura yevanhu vane Crohn's disease uye yakaienzanisa nezvisikwa kune vanhu vasina chirwere cheCrohn. Mhuri dzakabatanidzwa mukutsvakurudza, avo vakange vane nhengo neBD nevaya vakange vasina nhoroondo yeBD, vakange vari kuchamhembe kweFrance neBelgium. Zvakawanikwa nemasayendisiti ndezvokuti maviri emabhakitiriya, Escherichia coli uye Serratia marcescens , uye rumwe rudzi rwemafungus, Candida tropicalis , akawanikwa mune zvakawanda muvanhu vane Crohn's disease.
Apo mabhakitiriya uye fungus zvakadzidzwa murabhu, zvakawanikwa kuti zvakabatana uye zvakagadzira boka remasero anonamatira pamwechete, anonzi biofilm. Vatsvakurudzi vakatora iyi biofilm uye vakaita zvidzidzo zvakawanda mubazi, uye vakaratidza kuti zvakakonzera kuputika mumatumbo emukati. Kudzidza kwakakosha nokuti yakaratidza kuti pane kusiyana kwebhakitiriya uye fungus inowanika kune vanhu vane chirwere cheCrohn kana ichienzaniswa nevaya vasina chirwere cheCrohn.
Yakaratidzawo kuti mubazi rekuongorora, zvipenyu izvi zvinoshanda pamwechete kuti zvikanganisa masero mumatumbo. Zvisinei, chibereko chekutanga ichi hachina kukwana kutitaurira kana fungus uye mabhakitiriya zvine chokuita nekukura kwechirwere cheCrohn kuvanhu.
Saka Iye zvino Tava Kuziva Chii Chinokonzera Kurwara Kwezvirwere?
Aiwa, isu hatigoni kutaura zvakananga chinokonzera chirwere cha Crohn . Mitsva itsva pamusoro pekubatana pakati pefungus uye mabhakitiriya zvechokwadi kunotanga nzira itsva yekutsvakurudza. Zvisinei, yakanga iri kudzidza zvishoma.
Yakabatanidzwa mune chidzidzo chaiva mapfumbamwe mhuri dzakanga dzine nhengo dzaiva nechirwere chaCrohn nemhuri ina dzakanga dzisina nhengo dzaive neCrohn's disease.
Mhuri dzose dzaibva kune imwe nzvimbo nzvimbo (kuchamhembe kweFrance neBelgium). Pakanga pane vanhu 20 vane Crohn's disease, nhengo dzemhuri 28 dzakanga dzisina chirwere cheCrohn, uye vanhu 21 kubva kumhuri dzakanga dzisina mbiri yeCrohn's disease. Iyi inenge yevanhu 69, izvo zvisingakwani zvemuenzaniso kuti aite chirevo chakakura chinosanganisira vanhu vose vane chirwere cheCrohn munyika yose.
Uyezve, zvinofungidzirwa kuti panogona kunge kune mazana zana akasiyana-siyana eBD. Nyanzvi dzeBD dzinowanzoreva IBD sechirwere chinokonzera. Kana izvi zviri izvo, uye zviri kuwedzera kutarisa nenzira iyo, IBD inogona kuva nezvirwere zvakawanda zvinowirirana. Pari zvino masayendisiti uye vanachiremba vakaisa IBD muzvimedu zviviri, Crohn's disease uye ulcerative colitis (ine bhokisi rechitatu re indeterminate colitis kune vanenge 10 muzana yevarwere). Izvi zvinogona kuwedzera munguva yemberi apo tinodzidza zvakawanda pamusoro peBD. Paunotarisa IBD kubva maonero aya, pane chokwadi chichava "chimwe chinokonzera" uye imwe " mushonga ". Kana IBD iri, sezvinonzi nyanzvi dzinofunga, zvinopfuura zvirwere zviviri chete zvakasiyana, zvinonzwisisika kuti kuchave kune mamwe magene uye zvimwe zvinokonzera zvipenyu zvakabatanidzwa pakuzvikonzera.
Vashandi veBDD nevamwe vanofarira kuchengetedza nekutsvakurudza kwezvokurapa vangave vakanzwa mutsara wokuti "kuwirirana hakusi kukonzera." Izvi zvinoreva kuti kana zvinhu zviviri zvichiitika pamwechete, haisi nguva dzose iyo imwe yei inokonzera imwe. Vatsvakurudzi vanogona kuratidza kuti fungus uye mabhakitiriya mumvura yevanhu vane IBD vakasiyana kune avo vasina IBD, asi kuwirirana hakuiti kuti mabhakitiriya kana fungus anokonzera IBD. Zvakakosha kuratidza kuti kune chikonzero chakananga uye hukama hwehukama pakati pezvinhu zviviri zvisati zvaitika chero zvikwangwani zvingaitwa.
Nei MaMedian Outlets Achiti Tinoziva Chikonzero Chezvirwere zveCrohn?
Pane zvinhu zvakawanda zvinoita kuti imwe nyanzvi yekutsvakurudza iite zvakawanda. Chinhu chinosuruvarisa chekwenyika nyika ndechekuti inotungamirirwa nemugwagwa. Nenzira imwe chete yemapepanhau nemagazini vanotendeseka pane zvinyorwa zvekubhadhara, mawebvu anotenderera kuwanda kwevanhu vanoona mapeji uye mapeji mapeji avanoona. Chinyorwa chinotyisa kana chinotsausa chinogona kureva kuti nyaya inobatanidzwa munzanga yehupfumi uye yakanyanyisa pane nguva dzakawanda kupfuura imwe inoshandisa zvinyorwa zvechokwadi kana zvinyorwa.
Chimwe chikonzero mukugoverana kwemashoko nezvekutsvakurudza kwekutsvakurudza ndiyo mushure mokubudisa mapepa esayenzi. Munyori anonyora pepa anofanira kubva aita kuti pepa ravo rionekwe uye ribvumirwe. Kunyanya pepa racho rinopinda muimba dzevhidhiyo uye kupinda mune zvinyorwa zvinoshandiswa uye zvinokurukurwa, zviri nani. Izvi zvinogona kubatsira vatsvakurudzi kana hurumende kuwana mari yakawanda yekuita zvimwe tsvakurudzo.
Kunyatsotsvakurudza kunogara kuri chinhu chakanaka, asi mugumisiro wekupedzisira ndewekuti kune kuwanda kukuru kune masayendisiti kunyanya kutarisa zvakanyanya sezvinobvira kuswededzwa pakudzidza kwavo. Dhipatimendi rehukama hwehutano panzvimbo yekudzidza kwakaitwa kazhinji inobatsira kuwana izwi pamusoro pekudzidza patsva. Vanyori vanozobatana nevakawanda vezvinyorwa zvemashoko ezvinyorwa. Zvose zvinotora ndezvokuti rimwe rondedzero isinganzwisisiki kana kuti inotorwa kubva mumamiriro ezvinhu, izvo zvino zvinodzokorodzwa pamitambo yakawanda yevesheni, uye pane dutu rakakwana remashoko asina kunaka ayo angasambogadziriswa.
Tsananguro Inobva
Kutsvakurudza kwakakosha zvikuru kuvarwere vane IBD uye vanachiremba vavo. Izvo kuburikidza nokutsvakurudza kuti mushonga mutsva unogadzirwa uye zvakawanda zvinonzwisiswa pamusoro pezvikonzero zvinogona kupa BDI. Zvisinei, varwere vanofanira kushandisa pfungwa dzinofungisisa pavanenge vachiverenga nezvekutsvakurudza kweBD uye kuti zvinorevei.
Pakave nokuputsika, uye kuchava nezvakawanda, asi zvinosuruvarisa kuti hazvibviri kuva imwe chete, chikonzero chinogadzirisa kana chirwere chechirwere chakaoma seBDD. Kutsvakurudza kwehutano kucharamba kuchifambisa nheyo yezivo mberi, uye kuwedzera kukuru kwave kwatowanikwa kare. Hazvigoneki kuti pachava nepeji imwe yesayenzi ichazarura zvakavanzika zveBD, ndicho chikonzero nei tichifanira kuramba tichitsigira kutsvakurudza kwakawanda munharaunda yedu nehurumende, kusvikira tanzwisisa zvakawanda pamusoro peBD.
> Sources:
> Crohn's uye Colitis Foundation yeAmerica. Facebook post. 28 Sept 2016. https://www.facebook.com/ccfafb/posts/1114776048608272
> Hoarau G, Mukherjee PK, Gower-Rousseau C, et al. "Kubatana kweBacterium uye mycobiome kunosimbisa microbial dysbiosis muCrohn's disease yemhuri." [yakabudiswa paIndaneti Svondo 20, 2016]. mBio .
> Rehman J. "Kururamisira kweZvenyanzvi dzeMishonga paInternet." Scientific American. 2 Aug 2012
> Wood, M. "Sei tisina kuporesa chirwere chechirwere chinopisa?" Sayenzi Hupenyu. 6 March 2015.