Ndezvipi Zvinodhaka Zvinokurudzirwa Kubata Kurwara kwaCrohn Uye Ulcerative Colitis?
Mumakore achangobva kupfuura, kurapwa kwechirwere chechirwere chirwere (IBD) chakanyatsotariswa kubva kumakambani emishonga nevatsvakurudzi. Ramangwana revanhu vane IBD rakapenya kudarika kare, sezvo mamwe madhirairi ari muipi iyo yekurapa zvirwere izvi zvinoparadza uye zvinetso zvayo.
Alicaforsen
Alicaforsen ikozvino iri pasi peisense neAlantic Pharmaceuticals Limited.
Chirwere chacho chinoshandiswa neema uye chiri kuongororwa kushandiswa mu ulcerative colitis uye pouchitis . Alicaforsen yakapiwa mamiriro emishonga yemasana muUnited States uye European Union.
Alequel
Enzo Biochem yakapedza kudzidza naAlequel kune varwere vane uwandu hwechirwere cheCrohn. Chirwere chacho chirwere chinogadzirwa nemunhu wepuroteni ine-protekta inogadzirwa kubva kune zvisikwa kubva mumurwere wemurwere uye inoshandiswa mumuromo. Kuregererwa kwakagamuchirwa ne50 muzana yevarwere vari mumishonga, zvichienderana ne33 muzana ne placebo. Mushonga wacho wakanyatsotsungirirwa, pasina migumisiro yakaipa.
Teduglutide
Ichi chigadzirwa chitsva chiri kuidzidzwa kuti ishandiswe mune zvose IBD uye pfupi chirwere chinonzi bowel syndrome (SBS) . SBS inokonzera kukonzera, kubvongodza, kuputika, uye kuora mwoyo kunowanikwa kune vanhu vakave nehafu (kana kupfuura) yemukati wavo muduku vakabviswa. Chikonzero chinonyanya kukosha cheSBS chinodzokororwa nekuvhiyiwa kwepurojekiti inoshandiswa kurapa chirwere cha Crohn.
Zvimwe zvinokonzerwa ne teduglutide zvinoita sokuti hazvisi zvishoma, sezvo migumisiro inowanzoitika zvikuru mudumbu remukati. Vanhu vane SBS vakapinda mumuedzo we teduglutide vakaratidzira zvose zvakanyanya kuwedzera kudya uye muviri. Kazhinji zvinorondedzerwa zvinokanganisa zvinosanganisira kurwadziwa kwepamuviri, kuora musoro, kushanduka kwechimiro, uye kuzvimba.
NPS Pharmaceuticals, muvaki we teduglutide, akapedza uchapupu-hwe-gadzidzo yekuongorora kune varwere vane Crohn's disease. Pakati pevarwere vane Crohn's, 55 muzana vakange vakwanise kuregererwa mushure memasvondo masere ekushandisa madhiragi, vachienzanisa ne33 muzana yevarwere vanowana placebo. Iyo yakaipisisa yakashata yakashata yakanga iri yeropa panzvimbo yejojo. Chimwe chidzidzo chiri kuitwa kune varwere vane SBS.
Teduglutide yakagamuchira mamiriro emishonga yemasana muUnited States neEurope nokuda kwekushandiswa kwayo muSBS. NPS ikozvino iri kutsvaga musikana wekusimbidzika kuti arambe achiongorora chirongwa chekushandisa muCrohn's disease.
Traficet-EN (CCX282)
Traficet-EN is anti-inflammatory small molecule therapeutic iyo iri kuongororwa kuti ishandiswe muCrohn's disease kuburikidza nemuumbi, ChemoCentryx. Muchiedza chemazuva ano (PROTECT-1), chikamu chikuru chevarwere vanowana mushonga unobudirira kuregererwa mushure mavhiki makumi matatu kupfuura avo vakagamuchira placebo. Mushonga wacho wakanyatsorambidzwa pakati pevadzidzi vekudzidza pamusoro pemutambo wemwedzi 12.
Sources:
ChemoCentryx. "CCR9 Program.". 2010. 26 June 2010.
Enzo Biochem, Inc. "Alequel." . 2010. 26 June 2010.
Isis Pharmaceuticals, Inc. "Chirwere chekuputika." . 2010. 26 June 2010.
Margalit M, Israel E, Shibolet O, Zigmond E, Klein A, Hemed N, Donegan JJ, Rabbani E, Goldin E, Ilan Y. "Chirwere chemapiritsi maviri epofu ekurapwa kwechirwere cheCrohn kuburikidza nemutemo weAloquel, musanganiswa ye autologous colon-yakabviswa mapuroteni: nzira inorwara nevarwere. " Am J Gastroenterol March 2006 101: 561-568. 26 June 2010.
NPS Pharmaceuticals. "NPS Partnering Opportunities." 2010. 26 Feb 2012.