Nzvimbo Itsva Yemazuva Ekupedzisira Multiple Sclerosis Therapies
Kana iwe unotambura kubva kune MS kana kuti une mudiwa waunoita, iwe unogona kupedza nguva yakawanda uchifunga, uchida, kana kunyengeterera kurapwa kwakanaka, kunyange kuporesa. Nhau dzakanaka ndezvekuti pane nhamba yakawanda yerapi ye MS inodzidziswa iye zvino, zvose mubazi uye mukati memajeri emakiriniki. Chimwe chivimbiso chekurapa mberi ndeyekugadzirwa kwechigodhi che MS.
Kusiyanisa an MS Vaccine kubva kune dzimwe Mishonga
Paunofunga nezvemakemikari, vazhinji vedu tinofunga nezvekusimudza maoko edu kuti tiwane jekisi inotitadzisa kuwana zvirwere zvinotyisa, zvakadai sefivha, masero, kana rubella. Aya majekiseni ane virusi kana mabhakitiriya akave asina simba kana kuurayiwa kuitira kuti asatiita kuti tive nehutano chaizvo, asi tinonyengedzera masimba edu ezvirwere kuti tiwedzere mhinduro.
Asi chinangwa chekudzivirira kweSMS hachizove chidzivirira. Pane kudaro, ndiyo nzira inenge ichirapa. Izvi zvinoreva kuti zvingazopiwa kupa kudzivirira kana kuderedza kusimba kwezviratidzo zvakabatana neSMS nehutano hwehutano mumunhu anenge atoona kuti ane MS.
Imwe misiyano pakati pemishonga yemagariro uye munhu anonzi MS vaccine candidate ndeyekuti zvirwere zvepanyama zvakagadzirirwa kuchengetedza zvirwere zvinotapukira-kureva, chirwere chinokonzerwa nekutapukirwa nemakemikari epanyama, semakirusi kana mabhakitiriya.
Zvisinei, MS haisi chirwere chinotapukira. Pane kudaro, MS ndiyo chirwere chemotokari . Nokuda kwechimwe chikonzero, masimba edu ehurumende ari kurwisana ne myelin uye nerve fibers mukati mehutano hwedu hwepamusoro. Mune mamwe mazwi, MS inokonzerwa nechimwe chinhu icho muviri wedu uri kuzviita pachako, uye kwete chakakonzerwa nemuvengi wekune imwe nyika.
Saka, zvikamu zvevashandi veS MS vachengeti havasi microorganisms asi zvimwe zvinhu zvakagadzirirwa kuti "tweak" masimba edu ezvirwere nenzira dzakasiyana-siyana kuti tidzivise masero edu ezvirwere zvekuzvidzivirira kubva pakurwisa uropi hwedu nemutsipa wepelinha.
Chii chinonzi MS Vaccines Being Studies?
Heano mavheekeri mana akasiyana-siyana eMSS anoedzwa: Tcelna, NeuroVax, BHT-3009, uye RTL1000. Imwe yeropa idzi dzinoshandisa nzira yakasiyana-siyana kuti isvike chinangwa chekuvhara autoimmune basa rinopesana ne myelin.
Tcelna (yaimbova Tovaxin): Tcelna-iyo yaimbova inonzi Tovaxin-inonzi autologous T-cell vaccine, zvinoreva kuti inoumbwa nemunhu wemu myelin-anoshandiswa T-cells , avo vane mhosva yekurwisa myelin kuvanhu vane MS, izvo zvakaurawa. Nokupinza mukana mukuru wekudzokera kumashure mumunhu, Tovaxin inowana maitiro ezvirwere zvekuzvidzivirira kuti aparadze mamwe ose masero aya ari kupararira pasina kuchinja zvakasara zvezvirwere zvemuviri.
Ichi chirwere chakawanikwa chakachengeteka asi hachina kuwandisa zvakanyanya nhamba yegadolinium-inowedzera masvundu e MS mukuongorora vashanu varwere muna 2008. Iko zvino iri kuitika mune imwe kliniki yekuedzwa, yakatangwa muna 2012 pasi pezita rokuti Tcelna, kuti iongorore kuita basa mukuderedza uropi hutachiona uye kunonoka kukuremara.
NeuroVax: NeuroVax chirwere cheT-cell receptor peptide, chinoreva kuti chakaitwa kubva kune zvidimbu zveprotini izvo zvinoita sezvikamu zvepatigenic T-seli dzinorwisa myelin. Yakagadzirirwa kukurudzira muviri kuti uite zvakawanda zvekutonga T-masero anodzora basa reiyi pathogenic, kana kuti "yakaipa" T-masero.
Neurovax inorohwa mu musisi vhiki dzose mavhiki mana. Chikamu chechipiri mishonga yemakiriniki yechikwata chechipiri chinopfurikidza neyekuwedzera sclerosis ikozvino yakagadzirwa nokuda kwekudzivirira chirongwa ichi.
BHT-3009: Mushonga uyu unogadzirwa neA genetic engineered DNA iyo yakafanana neprotini mu myelin kuti maune immune masero anorwa, anonzi myelin basic protein.
Chinangwa chayo ndechokuisa "shanduko" iyo inotarisa maitiro ekuzvidzivirira kwezvirwere zvezvirwere zvemuviri, zvichireva "kudzidzira" masero emuviri omusimba anokonzera myelin sheath kuvanhu vane MS.
Ongororo dzesayenzi dzinoratidza kuti chirwere chacho chakachengeteka uye chinogadziriswa uye chinogona kunge chiri kupinda muGuisi III mishonga yechipatara nokukurumidza.
RTL1000: "RTL" inopfupika ne "T-cell receptor ligands" zvakare, iyo inonzi mapuroteni anonamatira kune muteereri weT-seli ari kukuvadza myelin kuvanhu vane MS. Nokubatanidza ma-receptor, T-masero haasakwanisi kuita kukanganisa. Dzimwe nyanzvi hadziisi iyi iyi mu "vaccine" maitiro apo vamwe vanoita.
RTL1000 yakawanikwa yakachengeteka uye inobvumirwa zvakanaka sechinhu chisina kukodzera chekutonga mune imwe chirongwa chechikamu chekutanga chechipatara. Vatsvakurudzi vari kuronga kuenderera mberi kuti vaongorore kuchengetedza kwayo nekubudirira semwedzi yakawandisa mumwedzi wekutsvaga muChikamu chechipiri.
Kufambira Mberi Kunofadza Mukuwanda Kwechiremera
Izvi zvinogona kurapa zvirwere zvinopa vazhinji vedu tariro. Hongu, ivo vachiri kuedza uye kure kure nekuwanikwa kune vazhinji vedu. Zvisinei, ivo vanofadza zvikuru. Funga kukurukurirana navo nechiremba wako nekutevera miedzo paCentical Trials Database.
Sources:
Correale J, Farez M, Gilmore W. Vaccines for multiple sclerosis: kufambira mberi kusvika zvino. CNS Zvinodhaka. 2008; 22 (3): 175-98.
Correale J & Fiol M. BHT-3009, myelin plasmid yeprotein-encoding inokosha yekurapa multiple sclerosis. Curr Opin Mol Ther . 2009 Aug; 11 (4): 463-70.
Multiple Sclerosis Association of America. (2013). Kuongororwa Mishonga: Tcelna (yaimbova Invaxin). Yakadzorerwa January 10th 2015.
Multiple Sclerosis Association of America. (2013). Kuongororwa Mishonga: BHT-3009. Yakadzorerwa January 19th 2015.
Yadav V et al. Kubata reT-Cell Receptor Ligand (RTL) pakurapa multiple sclerosis: A double-blind, placebo-controlled, phase 1, dose-escalation study. Autoimmune Dis . 2012; 2012: 954739.