Immune System Genes Yakabatanidzwa kune MS
Majini ako chinhu chinokosha pakuziva kana iwe uri pangozi yekuvandudza MS , sezvinotsigirwa nevemhuri uye zvidzidzo zvezesayenzi.
Zvidzidzo zveMhuri seChipupuriro chekuti Genesine Inotora Basa muna MS
Muhuwandu hwevanhu, pane 1 mu 750 mukana (0.1 muzana) mukana wekuti munhu achavaka MS. Asi iyo yakafanana mapatya emunhu ane MS ane inenge 25 kusvika ku40 muzana yemukana wekuvandudza MS, uye mukoma kana mwana kana munhu wemunhu ane MS ane 3 kusvika ku5 mukana.
Scientific Studies seChipupuriro chokuti Genes Play Inhare mu MS
Bhuku ra2007 rakabudiswa muNew England Journal of Medicine rakawana hutachiwana hwehutachiona hunokonzerwa ne multiple sclerosis (MS). Chidzidzo chinoratidza kuti vanhu vane zvimwe zvakasiyana-siyana zvemajini akasiyana-siyana anobatanidzwa mumuviri wemuviri (IL7RA uye IL2RA) vanowanzova neWS kupfuura vanhu vasina kuchinja uku.
IZ7RA naIl2RA mapurotini anotungamirira zviito zveumwe rudzi rwemune cell (T cells). Sezvo majini ari kutonga kuti mapurotini anogadzirwa sei mumuviri, kuchinja kweprotini yakasiyana kunomirira kusiyana kwema genetics.
Shanduro yakabatana ye MS-yeprotein inogona kuunza MS kuburikidza nekufambisa masero e-immune kuti arwise chirwere chetsitsi, chinotungamirira kukudzikisa uye zvipembenene muuropi nemutsara wesipfupa. Izvi zvinokanganisa, zvakare, zvinokonzera kuwanda kwakasiyana siyana kweMMS zviratidzo . Zvinofadza kuti IL2R kuchinja-shanduka kwave kuchibatanidzwa nechirwere chechirwere cheshuga neGraves 'chirwere, uyewo zvirwere zvemotokari .
Dzimwe tsvakurudzo dzakawanda dzakatsigira kuwirirana pakati peSMS nemakemikari anoronga masimba evanhu. Chikamu chinonyengera ndechekuti kune inenge yakawanda nhamba yakawanda yekuchinja kwechimiro, inofungidzirwa kuva 50 kusvika zana neNational MS Society, iyo inogadzirisa dambudziko remunhu wekuvandudza MS uye kana irikudziridza MS, yakaoma zvakadini.
Kuongorora ma MS genetic data kwakaoma uye nguva, asi zvakakosha, kunyanya kana zvingaita zviri nani kugadzirisa maTrapies.
Pasi Pasi
Zvakakosha kunzwisisa kuti kana majini ari kuita basa rinokosha mukusimudzirwa kweMM uye zvichida iyo ndiyo inotevera, haisi zvinhu zvose. Mune mamwe mazwi, MS haisi chirwere chakakonzerwa zvakakwana, saka hapana chivimbo chokuti iwe uchazoita kana kuti hauchazozviwana zvichienderana nehupenyu hwemhuri yako (kana iwe pachako mazita edziini).
Pane kudaro, nzira iyo MS inowedzera uye inozviratidza mumunhu inogona kunge yakaoma, inosanganisira simba pakati pemagenhi evanhu uye zvakatipoteredza. Semuenzaniso, ruzivo rwemagadzirirwo emagetsi hunogona kuita kuti munhu awedzere kunetseka pakuvandudza MS apo akaiswa kune chimwe chikonzero chekuchengetedza kwemhepo, sevirusi (kunyange, isu tisingazivi izvo zvinokonzera zvinoitika).
Sezvazviri ikozvino, vanachiremba havaiti kuongorora mazita evanhu vane MS kana vemhuri yevaya vane MS. Asi sezvo MS genetic kutsvakurudza kufambira mberi (iyo inokurumidza zvikuru), kurapa kunogona kusiyanisa zvichienderana nemunhu wega mazita ekugadzira.
Sources:
Gourraud, PA, Harbo, HF, Hauser, SL, & Baranzini, SE (2012). The genetics of multiple sclerosis: an up-to-date review. Immunological Reviews , Jul; 248 (1): 87-103.
International Multiple Sclerosis Genetics Consortium, et al. (2007). Risk alleles ye multiple sclerosis yakagadzirwa ne genomewide kudzidza. New England Journal of Medicine, Aug 30; 357 (9): 851-62.
National MS Society. Ndiani Anowana MS? (Epidemiology).
National MS Society. Zvinonyanya Kukosha: Genetics.
Sadovnick, AD, uye al. (1993). Chidzidzo chevanhu vanoverengeka zve multiple multiple sclerosis mumapatya: update. Annals of Neurology, Mar; 33 (3): 281-5.