The Link Between Aspirin and Asthma
Vanhu vazhinji havafungi kaviri pamusoro pekubuda aspirin kana vane musoro. Asi kune vamwe vanhu vane astmma , mhinduro iyi iri nyore inogona kuuraya.
Chii chinonzi Aspirin-Inofungidzirwa Nemafiropu?
Aspirin nedzimwe nhengo dzisiri dzisina kuvhiringidza (NSAIDS) dzakadai se ibuprofen , naproxen, uye diclofenac dzakawanikwa zvichiita kuti zvirwere zvinokonzerwa nehutachiona zvirwere kune vanhu vane chirwere chemafi.
Kurwiswa kwepifema kunokonzerwa ne aspirin uye NSAIDS inowanzova yakaoma uye inogona kunge iri kutyisa upenyu. Utsi hweuspirin hunowedzera kuwedzera sezvo vanhu vachikwegura, uye zvakaipa kune vanhu vane chirwere chakanyanya kuoma.
Iyi syndrome yave ichizivikanwa kwemakore akawanda, asi yakanga isingazivikanwi kuti vangani vanhu vane astmma vakasangana nemungozi pavanotora mishonga inowanzoshandiswa kushandiswa kusvikira zvidzidzo zvaitwa pairi.
Chidzidzo chikuru cha2004 chakaongorora zvidzidzo zvakaitwa pa aspirin-induced asthma (AIA kwenguva pfupi). Vatsvakurudzi vakashamisika kuona kuti 5 kubva muzana yevana vane asthma uye 21 muzana yevanhu vakuru vane astmma vakangotarisana neAIA.
Migumisiro yenyaya ino inokosha nokuti vanhu vaibatanidzwa vakanga vari "kupikiswa" ne aspirin munzvimbo yakarongeka, iyo yakagadzirira kuongororwa kwakajeka kwevanhu vangani vanobatwa neAIA. Nzira iyi yekuitisa chidzidzo ichi yakaderedza mikana yokuti vanhu vaizoita kuti varwere vavo vazvirwe kurwere hwavaive vachitora aspirin, chimwe chinhu chavakatsvakurudza chakaitika kakawanda.
Zvechokwadi, vatsvakurudzo vakawana kuti apo vanhu vakakumbirwa kuti vataure vasati vasangana neApirin-yakagadziriswa nekurwisana nehutachiona, chiyero chemhinduro dzakanaka chaingova 2.7 muzana chete.
Nei Aspirin Dzimwe Dzimwe Chimwe Chikonzero Chirwere Chirwere Chinoputira?
Vanachiremba uye vatsvakurudzi pakutanga vakatenda kuti chiitiko ichi chakanga chiri chinokonzera kugadzirisa aspirin.
Zvisinei, iko zvino inofungidzirwa kuti aspirin inokonzera kuputika kwechirwere mune vamwe vanhu nokuti aspirin inoshanda sekuregererwa kweeukotrienes. Leukotrienes zvinhu mumutumbi zvinokonzera kutuka uye dzakawanda zvezviratidzo zvehutenda.
Kune Apo Aspirin Zvinyorwa Zvakachengeteka Kune Vanhu Vane AIA?
Vanhu vane AIA vari panjodzi yekushandurwa kwechibvumirano kune NSAIDS, iyo inoshandiswa navanachiremba mishonga kune vanhu vanokonzera aspirin. Ongororo dzakawana kuti vanenge vanhu vose - ndivo vane AIA vanewo maitiro asina kunaka kuNSAIDS. Mukana wekutambura nekurwiswa kwepifema waiva mukuru kune vanhu vakagamuchira kunyange maduku maduku e aspirin.
Varwere vane AIA vakaedzwawo kuti vaone kuti vangapindura sei acetaminophen (Tylenol), imwewo nzvimbo inowanzoitwa aspirin. Neine mishonga, 7 chete yezana yevanhu vane AIA vane maitiro ekufema. Zvakare, avo vainyanya kufunga nezve aspirin vaiwanzoita zvakare kune acetaminophen zvakare.
Chimwe chikwata chemarwadzo ekurambidza remliever, iyo inopesana neyokuvhiringidza cyclooxygenase-2 (COX-2) inhibitors yakadai se celecoxib (Celebrex), inoshanda pane imwe nzira inopesana nekuputira kupfuura aspirin neNSAIDS. Nemhaka yokuti mishonga iyi ine chinangwa chakanyanya mumugwagwa unovhiringidza, haisi kuve nechinetso chimwechete kune vanhu vane astmma.
Kunyange zvazvo COX-2 inhibitor isingabatsiri zvakakonzera kukonzera kuputika kwepimma yakadai seAspirin neNSAIDS, zvinodhaka zvinokonzerwa neCCO-2 zvinogona kuwedzera njodzi yekurwadziwa kwepfungwa uye kurohwa. Vanhu vane AIA uye avo vanoda mishonga inopesana nekuputira vanofanira kutaura nachiremba wavo pamusoro pezvipingamupinyi uye zvigaro zve celecoxib.
Kurapa uye Kudzivirira Aspirin-Inobatsira IAsafi
Vanhu vane AIA vanowanzoita zviratidzo mukati memaminitsi makumi matatu kusvika maawa maviri mushure mekutora aspirin kana NSAIDS, uye kuoma kunokonzerwa nokufema kungatora kwemaawa. Mushonga wacho wakafanana neaya kune chero ipi zvayo inonzi asthma attack - kuponeswa-nokukurumidza-kuponesa inhaler, uye oxygen uye steroids nokuda kwezviratidzo zvakakomba.
Leukotriene modifiers ndeimwe rudzi rwemishonga inonzi asthma inogona kuwedzera zviratidzo kune varwere vane aspirin senzwi. Nemhaka yokuti mishonga iyi inomisa zviito zveeukotrienes, izvo zvakaratidzwa kuti zvinotamba basa guru muAIA, mishonga iyi, pamwe chete ne-steroid inhaled, inowanzopiwa kuvanhu vane AIA.
Nzira yakanakisisa yekudzivirira mishonga-inokonzerwa nechirwere chekushaya zvirwere ndeyokudzivisa zvachose aspirin neNSAIDS. Vanhu vane asthma uye havana chokwadi kana vakagamuchira aspirin munguva yakapfuura vanofanira kubvunza chiremba wavo kana zvakachengeteka kuedza kushushikana ne aspirin neNSAIDS. Izvi zvinofanira kuitwa chete mumamiriro ekudzivirirwa nekuda kwehutano hwekuita kwakakomba.
Vanhu vanozivikanwa aspirin / NSAID senitivity vanoda kutsvaga aspirin kana anti-inflammatory mishonga yekurapa mamwe mamiriro ezvinhu, akadai sechirwere chemwoyo kana zvirwere zverheumatic, zvinorudzirwa kuti iite aspirin deensitization. Izvi zvinogona kuitwa nachiremba uyo anoyevedza mune zvechirwere uye immunology. Kana izvi zvave zvichiitwa, zvinokosha kuti munhu arambe achitora aspirin zuva rega rega, saka acharamba achishushikana.
Sources:
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Jenkins, C., Costello, J., & Hodge L. Kugadziriswa kwehutano hwehuwandu hweAspirin yakakonzera chirwere uye zvinokonzerwa nekliniki. " BMJ 2004 Feb 21; 328 (7437): 434.
Macy, E., uye al. Aspirin nharo uye kuora mwoyo kweAspirin-yakawedzera chirwere chekufema: Muitiro. Ann Allergy Chirwere Immunol. 2007 Feb; 98 (2): 172-4.
National Heart Lung uye Blood Institute. Dhipatimendi reUnited Health Health and Human Services, National Institutes of Health. (August 2007). Rapport Panel Panel Report 3: Mirayiridzo Yekuongororwa uye Kutungamirirwa kweAhma: Full Report 2007 .