Rudzi rwakawanda rushoma rweMS runogona kutora nguva yakareba kuti ruongorore
Kuongororwa kwepamusoro progressive multiple sclerosis (PPMS) ine zvipingamupinyi zvakasiyana, sezvo vanhu vane PPMS vane zvishoma nezvishoma kurasikirwa kwebasa kwemwedzi kusvika kumakore. Izvi zvinopesana nekudzoka zvakare-kusunungura MS, umo munhu anogona kugadzirisa mafungiro emagetsi pashure pokudzokazve.
Kusiyana pakati pemhando mbiri idzi dzeSMS kune chimwe chinhu chekuita nehupenyu husina maturo shure kwavo.
Kutsvakurudza kunoratidzira kudzokera zvakare-kuregererwa kweSMS chirongwa chekuvhiringidza (maitiro emumasimba anorwisa nerve fibers) asi chekutanga MS inopfuurira ndiyo inowedzera kugadziriswa, iyo inonzi fiber fibers inowedzera kuwedzera. Chikonzero nei munhu mumwe arikuita PPMS kusiyana nekudzoka zvakare-kuregererwa kwe MS hakuzivikanwi, asi nyanzvi dzinofunga kuti majini anogona kuita basa, kunyange zvazvo uchapupu hwezvesayenzi hwokudzoka ichi huchiri hanya.
Kuongororwa Kwepamberi Inofambira mberi MS
Dhigirii PPMS inogona kuongororwa apo zvinotevera zvinosangana:
- Munhu ane gore rimwechete rekunyorwa kwekuchirapa kwechipatara (zvinoreva kuwedzera kwezviratidzo zveSMS ).
- Zvinenge zviviri zvezvinotevera:
- Uropi MRI lesion iyo inowanzoitwa MS
- Mamwe maviri kana akawanda emasipiresi emumutsara
- A positive lumbar puncture, zvinoreva kuti kune uchapupu hweimwe hunigoclonal bands kana kuti yakakwirira yeGG anti-level level (aya ndiwo mapuroteni anoratidza kuputika kunoitika mumuviri)
Vanhu vazhinji vane PPMS vanotanga nechiratidzo chekuwedzera kuwedzera matambudziko nekufamba, kunonzi "kufambira mberi kwepastaresisis".
Zvisinei, vamwe vanhu vane izvo zvinonzi "cerebellar syndrome," iyo inoratidzirwa neattaia yakaoma uye nezvinetso zvine mutengo. Pasinei nokuti ndeapi zviratidzo zvezviratidzo zvavari, zvinofanira kuratidzirwa kuti kufambira mberi kwave kwakasimba kwenguva inopfuura gore, pasina kubvazve, kuongorora PPMS.
MRI muKutsvaga PPMS
Kuongororwa kwe multiple multiple sclerosis kunoda kuparidzirwa (kuwedzera) kwezviratidzo uye zvipembenene munzvimbo nenguva. Iyo "kuparidzirwa munguva" inotarisirwa nekuderera kwezviratidzo kwegore rimwechete (sezvakakurukurwa pamusoro). MRI inoongorora inoshandiswa kutsanangura "kuparadzirwa kwezvipembenene munzvimbo."
Izvozvo zvakati, kushandisa MRI kuongorora kuongorora PPMS ine zvinetso zvayo. Chimwe chinetso chikuru ndechokuti migumisiro yeMRI scan ye ubongo hwevanhu vane PPMS inogona kuva "yakavanzika" kupfuura yevanhu vane RRMS, uye ine zvishoma zvishoma gadolinium-enhancing (active) .
Kunyange zvakadaro, mutsara wemutsipa weMRI wevanhu vane PPMS ichaita sekurukuro atrophy . Sezvo rwonzi rwepelinha rune simba zvikuru muPPM, vanhu vanowanzova nematambudziko nekufamba, pamwe nekusuruvara uye maronda kusagadzikana.
Lumbar Kupera Mukuona Chirongwa chePMS
Zvakare zvinonzi semupopu, pumbus lumbar inogona kubatsira zvikuru pakuita kuti kuongororwa kwePMS uye kutonga kune dzimwe mamiriro.
Zviwanikwa zviviri zvakakosha mukusimbisa kuongororwa kwePPMS:
- Kuvapo kweOligoclonal Bands: Izvi zvinoreva kuti "zvikwata" zvemamwe mapuroteni (immunoglobulins) anoratidza apo maronda emuspini ari kuongororwa. Uchapupu hwezvikwata zve oligoclonal muCSF zvinogona kuonekwa mune makumi mapfumbamwe zvemazana evanhu vane MS asi zvinogona kuwanikwa mune dzimwe dambudziko, zvakare.
- Intrathecal IgG Antibody Production: Izvi zvinoreva kuti IgG inobudiswa mukati memubhedha wemaspine-ichi chiratidzo chokuti kune maitiro ezvirwere zvemuviri.
VEP inobatsira kusimbisa kuongororwa kwe PPMS
Kutaridzika kunokanganiswa kunganganisa kuve kunosanganisira kupfeka maEEG (electroencephalogram) sensor pachikanda pachitarisa mutsvuku-uye-white checkered pattern pachigadziko. EEG zviyero zvakaderedza kupindura kune zviitiko zvinoonekwa, izvo zvinoratidza kusagadzikana kwehutano. VEPs zvakare dzakabatsira mukusimbisa kuongororwa kwePPM, kunyanya apo dzimwe nzira dzisati dzasangana zvakananga.
Kufambira mberi-Kudzokorora MS
Zvakakosha kucherechedza kuti vamwe vanhu vanotanga nekuongororwa kwePPMS vanogona kuvezvezve mushure mekunge vaongororwa.
Kana imwe nguva ichitanga kuitika, kufungidzirwa kwomunhu iyeyo kunoshandurwa kuva kufambira mberi-kudzoka zvakare MS (PRMS). Zvisinei, munhu wese ane PRMS anotanga nekutarisa kwePMS. Kufambira mberi-kudzoka zvakare MS ndiyo inonzi rarest ye MS, ine 5% bedzi yevanhu vane MS vanobatwa.
Shoko Rinobva
Pakuguma, zvirwere zvizhinji zvehutano zvinokonzera MS , zvakanyanya zvemutoro wekuona chero rudzi rweSMS ruri kubvisa kukanganisa kuti ingava chimwe chinhu. Zvimwe zvinetso zvinoda kubudiswa kunze zvinosanganisira: Vitamin B12 inoshaya, chirwere cheLyme, kushandiswa kwemutsipa wesimbi, neurosyphilis kana chirwere chinonzi neuron, kungoti vashoma.
Ichi ndicho chikonzero zvakakosha kuona chiremba kuti awane chirwere chakakodzera kana iwe uine zviratidzo zvehutano. Kunyange zvazvo chirongwa chekuongorora chinogona kunge chinotyisa, ramba uine mwoyo murefu uye uchiita zvakanaka mune zvehutano hwako.
> Sources:
> Coyle, Patricia K. uye Haper, June. Kurarama neProgressive Multiple Sclerosis: Kukunda Matambudziko (2nd ed.). New York: Demos Publishing. 2008.
> Cree BA. Genetics ye primary progressive multiple sclerosis. Handb Clin Neurol. 2014; 122: 211-30.
> National MS Society. Kuongororwa PPMS.