Fibratesiti, inozivikanwawo seFiber acid derivatives, ikirasi yezvinyorwa-kuderedzera zvinodhaka zvinokwanisa kukanganisa zvikamu zvose zvehupfumi hwako.
Nzira iyo fibrates inowedzera cholesterol yakaoma. Fibrate inobata puroteni inonzi peroxisome proliferator-activated receptor alpha (PPAR-alpha). Iyi proteiniti inogona kushandisa imwe enzyme, lipoprotein lipase, iyo inoderedza kuwanda kweapolipoprotein C-III mumuviri.
Pakupedzisira, izvi zvinoguma nekugadzirisa maitiro eVLDL uye triglycerides uye inowedzera kuparara kwe lipids. Fibratesiti inowedzerawo muHCDL nekuwedzera huwandu hweapolipoprotein AI neA-II yakaitwa mumuviri.
Kune ikozvino maviri emishonga eFyrate yakagamuchirwa kuti ishandiswe neChadya neDrug Administration (FDA) muUnited States:
- Gemfibrozil (Lopid)
- Fenofibrate (Tricor)
Fibratesti inonyanyozivikanwa nekuderedza triglycerides uye kuwedzera HDL cholesterol. Zvisinei, zvinogona kukanganisa zvose zvehutano hwako. Kazhinji, fibrates inogona:
- Chengetedza yako LDL cholesterol mazinga ne 5 muzana kusvika 20 muzana.
- Wedzera yako HDL cholesterol chero ipi zvayo kubva pakati pe10 kusvika kune 35 muzana.
- Chengetedza hutatu hwetrglyceride nema20 muzana kusvika 50 muzana.
Kuti uwedzere kunatsiridza huwandu hwako hwehuputi, fibrates inogona kutorwa yoga kana inosanganiswa nedzimwe nhengo dzakaderera dzakadzika, dzakadai semasitini kana omega-3 fatty acids.
Maitiro Aunofanira Kutora Kutama
Iwe unofanirwa kutora fiber yako sezvinorayirwa nemupi wako wehutano wehutano uye iwe unofanirwa kunge uine chokwadi kuti haufaniri kukanganwa maitiro. Zvose mishonga yefiber inowanika mupepeti uye inotorwa nemuromo. Kunyangwe iwe unogona kutora zvose zviri zviviri zve fibrates kana kuti pasina kudya; zvisinei, zvidzidzo zvakaratidza kuti kutora fiber, gemfibrozil, pamwe nekudya kunobatsira kuwedzera kuwedzerwa kwayo.
Iwe unofanirwawo kuve nechokwadi kuti usasarudzwa chero hupi hwemagadziro ako nemupi wako wehutano hwehutano, sezvo iye achange achida kuongorora kana kana kwete mishonga ichikushandira iwe. Mushandi wako wehutano angave achida kugadzirisa mukurapa kwako-kuderedza chirwere, zvichienderana nemhinduro yako kumushonga. Paunenge uchitora fibrates - kana chero ipi zvayo inorapa-inoderedza kurapwa - iwe unofanirwawo kuva pedyo nekudya kuderedza cholesterol yako uye triglycerides.
Pane Mhinduro Dzepamwe Unofanira Kuitarisa?
Kunyange zvazvo fibrates inobvumirwa zvakanaka pakati pevanhu vanovatora, unogona kuve nemimwe migumisiro kubva pakuvatora, Izvo zvinowanzovhiringidzirwa zvinosanganisira zvinosangana nematambudziko emagumusi, zvakadai sekuora mwoyo, chirwere, nekurwadziwa mumimba. Izvozvo zvinowanzova zvinyoro uye, pane dzimwe nguva, enda shure mushure mekutanga yako fibrate.
Mune zvimwe zviitiko, fibrates inogona kuwedzera chiropa chako chemavirisi, saka kuwedzera kune lipids yako, uyo anopa utano hwehutano achaongororawo mavhinga enzymes eropa nguva nenguva. Kana iwe uine chirwere chenduru, iwe unofanira kurega mupi wako wehutano hwehutano achiziva, sezvo pane ngozi shomanana yekudzikisa mazamu paanotora fibrate. Zvinomera zvinogona kukonzera mamiriro ezvinhu anonzi rhabdomyolysis.
Kunyange zvazvo zvisingawanzoitiki, mukana wekugadzirisa chirwere ichi paunotora fibrates kuwedzera kana uri kutora mamwe mishonga pamwe chete nefiber yako kana mune zvimwe zvirwere.
Zvinotapudza zvinogona kuwedzera mukana wako wekutarisa ropa kana uri kutora ropa rakaonda, rakadai seCoumadin ( warfarin ). Nokuda kweizvi, mupi wehutano wako anogona kugadzirisa chirwere chako paanenge achitora fibrates.
Matambudziko anowanikwa ne-fibrate anowanzova munyoro, asi anofanira kuendeswa kumutarisiri wako wehutano anotarisa kana akave achishungurudza kana kuti anoramba kwenguva yakati. Unofanirwa kubvumira mutapi wako wehutano kuziva nezvemishonga ipi yaunotora-kusanganisira chero yemishonga kana yepamusoro-ye-makambani-kana mararamiro aunoita kuitira kuti anogona kukucherechedza zvakanyanya munguva yekurapa.
Sources:
> Dipiro JT, Talbert RL. Pharmacotherapy: A Pathophysiological Approach, 9th, 2014.
Malloy MJ, Kane JP. Agent anoshandiswa muDyslipidemia. Mu: Katzung BG, Trevor AJ.eds. Basic & Clinical Pharmacology, 13e . New York, NY: McGraw-Hill; 2015.