Juxtapid (mamitapide) imishonga inoshandiswa kunyanya kuderera pasi rose muhotera, LDL, uye apolipoprotein B mazinga - pamwe chete nekudya uye mamwe marapirwo - mune vanhu vane homozygous family hypercholesterolemia , chiitiko chisingawanzi, chakazvarwa chinokonzera zvikuru kwazvo LDL cholesterol mazinga uye nemwoyo chirwere pakutanga kweupenyu. Juxtapid yakabvumirwa kushandiswa muUnited States neDain and Drug Administration muna December 2012.
Juxtapid inongodzidza zvakanyatsoitika kune vanhu vanozivikanwa neye homozygous family hypercholesterolemia - uye kwete mune vanhu vane mamwe mamiriro ezvinhu anokonzera cholesterol yakakura. Mune rumwe ruzivo, Juxtapid 5 kusvika ku 60 mg zuva rega rega yaibatanidzwa kune vamwe vanhu vatotora mamwe echolesterol-kuderedza kurapwa kwepamusoro-soro yeLDL cholesterol mazinga. Ichi chiitiko chakazarura kuti kuwedzera Juxtapid kune dzimwe nzira dzokurapa dzakaderedza mazinga eLDL kusvika 50%. Triglyceride mazinga, apolipoprotein B mazinga, VLDL uye zvakakwana zveklesterol mazinga zvakanyanyawo kuderedzwa.
Imwe yedzidzo yakatsvaga kubudirira uye kuchengeteka kune vanhu vane chirwere chakafanana chinotora Juxtapid chete kuti vaderedze cholesterol. Pakupera kwechidzidzo ichi, pamwero we 1 mg / kg / zuva, mazinga eLDL uye apolipoprotein B mazinga akaderedzwa ne50%.
Kunyange zvazvo izvi zvakawanikwa zvichibatsira zvakanyanya kuderedza cholesterol muhuwandu hwevarwere ava, vakatsanangurawo Juxtapid inogona kukonzera matambudziko makuru - kusanganisira maitiro emagumisiro uye chirwere cheropa.
Uyezve, sezvo zvidzidzo izvi zvave zvichitora kusvika masvondo makumi manomwe nemana, zvimwe zvidzidzo zviri kuitwa iye zvino kuti zvione kusachengetedzwa kwenguva refu uye kubudirira kweJuxtapid.
Chinoshanda sei?
Juxtapid inoderedza LDL cholesterol nekudzivirira microsomal triglyceride kutumira puroteni (MTTP), molecule mumuviri unoita kuti VLDL nemakylomicrons vasagadzirwa muchiropa.
Nokuti VLDL inoshandurwa kuva LDL, izvi zvichaitawo kuti kuderedza maLDL muropa.
Ndinofanira Kutora Sei Mishonga Iyi?
Juxtapid inofanira kutorwa nemuromo, negirazi remvura, pane isina chinhu mudumbu. Zvinonzi mishonga inotorwa maawa maviri mushure mekudya kwemanheru. Mupiki wako wehutano achapedza kuongororwa kweropa - kusanganisira kuongorora enzyme yeropa uye mazinga e-cholesterol - asati agadza Juxtapid kwauri.
Migumisiro Yacho Inogona Kuitika
Yakawedzerwa mavhinga eropa uye kuunganidza mafuta mukati mechiropa zvakabatanidzwa zvakasimba nokutora Juxtapid. Nokudaro, chiremba wako achada kutora periodic test test kuti aone chiropa chako chinonzi enzyme, iyo inosanganisira alanine aminotransferases, aspartate aminotransferase, uye alkaline phosphatase, kunze kwekutarisa cholesterol yako. Nemhaka yemigumisiro iyi, Juxtapid inotakura "black box warning" ye hepatotoxicity, iyo inyevero yakasimba yakabudiswa neAkadya neDrug Administration nekuda kwekuti izvi zvakasvibiswa zvakaratidzwa mukuongorora kuongorora kuchengetedza kwemishonga. Nemhaka yekuti inogona kukuvadza Juxtapid ine pachiropa, chiremba wako achaita kuti iwe unyoresa purogiramu isina kurongeka, inonzi chirongwa cheJuxtapid REMS.
Pasi purogiramu iyi, ndivo vanachiremba uye ma pharmacy chete anozivikanwa pakunzwisisa mishonga uye njodzi dzayo dzinogona kupa uye kuparadzira Juxtapid.
Matumbu emigumisiro, zvakadai sokunyunyutira, kurutsa, kuora mwoyo, kurwara kwemararamiro, kuvhiringidzika uye kurwadziwa kwepamuviri, ndizvo zvave zvakanyanya kuitika migumisiro kune vanhu vanotora Juxtapid. Vamwe vanhu vakataurawo vachirasikirwa nekurasikirwa, kuora kwepfupa, uye kuneta pavanotora mishonga.
Ndiani Asingafaniri Kuitora?
Parizvino, Juxtapid yakangodzidza kune vanhu vakawanikwa vane homozygous family hypercholesterolemia nemhaka yehutano hwavo hwehutano hwepfungwa.
Nokudaro, hazvizivikanwe kana Juxtapid inoshanda kune vamwe vane zvimwe zvirwere zvinokonzera kukwidziridzwa kwepamusoro. Vamwe vanhu vanofanirwa kubvunzurudza chiremba wavo vasati vatora Juxtapid vanosanganisira:
- Vanhu vane chirwere chechiropa - Juxtapid inogona kuwedzerwa kuwedzera enzymes eropa yakadai se transaminase uye kuwedzerwa chiropa mafuta.
- Vanhu vane zvirwere zvetsvo - Juxtapid mazinga anogona kuwedzera muropa.
- Vakadzi vane pamuviri - Juxtapid yakaratidzwa kunge inokuvadza kumucheche muzvidzidzo zvemhuka. Vakadzi vanogona kubereka vachada kuve nemuviri wekutora mimba vasati vatanga Juxtapid uye vachada kushandisa imwe nzira yekubatsira kuberekwa nekuberekwa pavanotora mishonga.
- Vakadzi vanoyamwisa - Juxtapid haina kumbove yakanyatsodzidza. Nemhaka yezvakakonzerwa nekukura kwemuviri mumakonzo, zvinokurudzirwa kuti mukoti - kana mishonga - inofanira kuregwa.
Kubatana Kwemishonga
Kune dzimwe mishonga inogona kuwirirana naJuxtapid, iyo inogona kuguma nekukanganisa kuwanda kweJuxtapid kana mamwe mishonga mumuviri. Izvi zvinotevera mapfupi emishonga inogona kuwirirana naJuxtapid saka kana iwe wakatora imwe kana kupfuura iyi mishonga, unofanira kubvunza chiremba wako.
- Mavhithamini ane mishonga yakasvibiswa uye michina, yakadai seVithamini A, D, E, uye K, uye omega-3 fatty acids , inogona kunge isingasanganisi pamwe chete pakutora Juxtapid.
- Juxtapid inogona kuwedzera ropa rehumwe ropa rakasara , rakadai sehondo, muropa. Izvi zvingakonzera kuti iwe uise ropa kana kupwanya nyore nyore.
- Kana iwe uri kutora atorvastatin kana simvastatin, Juxtapid inogona kuwedzera ropa remishonga iyi. Chiremba wako angashandura mazamu ako emishonga paanotora Juxtapid.
Nemhaka yenzira iyo Juxtapid inogadziriswa mumuviri, inogona kuwedzera ropa remamwe mishonga iwe uri kutora-saka kuita kuti mishonga isvike. Izvi zvinosanganisira zvimwe zvinodhaka, mishonga inorwisa mabhakitiriya, mishonga yemishonga yemishonga, ropa remishonga yemishonga, zvinodhaka zvinoshandiswa kugadzirisa mwoyo, uye zvinhu zvinowanikwa (zvakadai segolideenseal, mazambiringa). Nokudaro, iwe unofanira kuchengetedza vese vanopa utano hwehutano kuti vazive chero mishonga yauri kutora kuitira kuti vanyatsokwanisa kutarisa kwekugona kusangana naJuxtapid. Chiremba wako angasarudza kuchinja mazamu ako eJuxtapid kana mamwe mishonga kana kubatana kwaonekwa.
Pasi Pasi
Juxtapid ndiyo yekutanga cholesterol-kuderedza mishonga inogamuchirwa inodzivisa MTTP. Kunyange zvazvo zvidzidzo zvakaratidza kuti Juxtapid inowedzera mamwe maLDL-kuderera kwepamusoro kune vanhu vane mazinza e-homozygous hypercholesterolemia, pane zvakawanda zvekuchengeteka zvinobatanidzwa naJuxtapid uye kushandiswa kwayo kwave kuri kungoenderana nehutano huno hutano nekuda kwezviitiko izvi. Chiremba wako achaongorora kubatsirwa kwekutora Juxtapid, pamwe chete nezvipingamupinyi zvekutarisana nemigumisiro pamwe nemishonga. Nemhaka yokuti nguva yakareba migumisiro yekutora Juxtapid haisati yazivikanwa - kusanganisira kukwanisa kwayo kudzivirira chirwere chepfungwa - pane zvidzidzo zvinoenderera mberi kuongorora izvi.
Sources:
Cuchel M, Meagher EA, Theron HD, et al. Kubudirira uye kuchengeteka kwemucrosomal triglyceride kutumira protein inhibitor kune varwere vane homozygous mhuri ye hypercholesterolemia: imwe-ruoko, ruvara-ruvara, chidzidzo chechitatu. Lancet 2013; 381 (9860): 40-6.
Cuchel M, Bloedon LT, Szapary PO, et al. Inhibition ye microsomal triglyceride kutumira mapuroteni mumhuri ye hypercholesterolemia. N Eng J Med 2007; 356: 148-156.
Juxtapid ® (pamitapide) Package Insert. Aegerion Pharmaceuticals. March 2016.