Iwe Iwe Kana Kuti Wako Wawakada Kanothe Chemotherapy Inokundikana Here?
Vanhu vazhinji vakanzwa nezvemashoko, "kenza" uye "chemotherapy". Asi kunze kwekuti chemotherapi inoshandiswa kurapa kenza, vanhu vakawanda havazive nehuances dzinosanganisira chemotherapy, sezvinoreva izwi rokuti "chemorefractory" rinoreva.
Muchidimbu, "chemorefractory" ine chokuita nekupindura chemotherapy mishonga. Kuti unzwisise zvakanyanya "chemorefractory," ngatitangei nheyo dzechemotherapy.
Chemotherapy Basics
Iko kune anopfuura zana emhando dzakasiyana dzemakemikarirapies anoshandiswa nevanachiremba vanachiremba (anonzi oncologists). Zvichienderana nemunhu wemhando yekenza uye chirwere chekenza, an oncologist achasarudza imwe kana kusanganiswa kwekemotherapy mishonga.
Administration
Chemotherapy inogona kupiwa nenzira dzakasiyana-siyana. Mimwe mishonga inogona kutorwa nemuromo (somuenzaniso, sehwendefa kana kuti mumvura yakadzika) asi dzimwe dzinoshandiswa sejisi, kana mumusungo kana mafuta.
Mimwe chemotherapies inoshandiswa mu cerebrospinal fluid kuburikidza nemugunha wemugunha (unonzi intrathecal chemotherapy ), mudumbu kuburikidza necatheter, muchipfuva kuburikidza nebhokisi rebhuti, kana kunyange pamusoro (pamusoro peganda).
Kakawanda, kunyange zvakadaro, ruzhinji rwechemotherapies runopiwa kuburikidza nemutsipa wemunhu, uye izvi zvinonzi kushandiswa kwemukati.
Mechanism
Chemotherapy inoshanda nokuuraya masero anokura nokukurumidza, sekenza masero.
Mamwe mashoma, masero masero, kunyange zvakadaro, anokurawo nokukurumidza, semasero mumuromo uye mudumbu, masero ekugadzira ropa, uye masero anoita bvudzi. Ichi ndicho chikonzero vamwe vanhu vanorasikirwa nevhudzi ravo pavanotora mamwe marudzi emakemikirini, kuve nekutuka nekunyora muromo, kuve hoemic, uye / kana kukura nhamba yakaderera yemasero-mauto masero (anonzi masero eropa rega).
Apo chemo inoshanda nekuuraya masero emukenza, chinangwa chingasiyana. Mune mamwe mazwi, chinangwa kana chiitiko chinotarisirwa chekutarisa chemo hachisi chakafanana kune munhu wose.
Somuenzaniso, apo chemotherapy inowanzopiwa kurapwa kenza, inogona kushandiswa panzvimbo pokuderedza chiremera chakakwana kuti isunungure marwadzo anokonzerwa nekenza (inonzi palliative chemotherapy ) kana kupedza tumarara pamberi pokuvhiyiwa (kunonzi kushanduka chemotherapy).
Mhinduro
Mhinduro, inotaridzwa panguva dzakasiyana (kazhinji mushure memaviri kusvika matatu kutenderera chemotherapy), inoreva kuti zvinoshanda sei mishonga chemo inouraya masero ekenza.
Vanachiremba vanoyera kupindura nenzira dzakasiyana-siyana zvichienderana nehuwandu hwekenza. Semuenzaniso, chiremba anogona kuraira nguva yeC CT scans uye / kana kuongorora kweropa kuti aone chiremera chemavara . Iyi miedzo inodzokorora nguva dzenguva dzose, saka dzinogona kuenzaniswa.
Mhinduro uye Its Connection ku "Chemorefractory"
Izwi rokuti "chemorefractory" kana "kemosensitive" kenza rinotsanangura kusateerera kwekenza kumishonga inorwisana nayo.
Kana kenza inopindura chemotherapy, zvinoreva kuti inopera kana inopera mushure mekunge munhu agamuchira mishonga chemo, kenza inotsanangurwa se "chemosensitive."
Pamusoro peflip side, kana kenza i "chemorefractory," hairegi kana kuparara mukupindurwa nemishonga inoshandiswa chemo.
Dzimwe nguva kenza inonzi chemorefractory inogona kurondedzerwa se "kusakonzerwa kwekenza chemotherapy," kana kuti "kupikisa chemotherapy."
Zvakakosha kucherechedza kuti kenza inogona kukanganisa chemotherapy nguva pfupi (sekutanga kwerapi) kana inogona kuve yakanganisa panguva yekurapa.
Mune mamwe mazwi, chirwere chinogona kutanga chinopindura chemotherapy uye kuva duku, chete kumira kupindura uye kusashandura ukuru, kana kutoka kukura.
Kunyanya kunyanya, pakutsanangura kupindura (kana kusava nemhinduro) chemotherapy, oncologists vanoshandisa mazwi aya:
- Mhinduro yakakwana yakataurwa kuti inoitika apo yese yekenza inopera.
- Kushanda kwepashoma kunoreva kuti kenza yakadonha asi haina kupera zvachose.
- Kugadzikana kwakasimba kunoreva kuti kenza haina kumira, asi hainawo kukura.
- Kana kenza ichifambira mberi, yakakura, zvinoreva kuti kune kenza yakawanda kupfuura yekare kusati kwaitika chemotherapy. Muchiitiko ichi, chiremba angamisa chemotherapy uye / kana kuchinja kune chemotherapy yakasiyana.
Chikonzero Nei Kanzerano Yako Inogona Kuve Chemorefractory
Pane zvikonzero zvakawanda nei chirwere chinogona kunge chiri chemorefractory uye kunzwisisa zvikonzero izvi chinhu chinokosha pakuvandudza zvigadzirwa zvemishonga. Chimwe chikonzero ndechekuti masero emukenza anogona kuchinja mune maitiro avo, izvo zvinoita kuti zvive zvisina kukodzera chemotherapy. Imwe nzira inonyengedza yokuti kenza dzemasikironi dzinova chemorefractory ndeyokunyora kupeta mishonga chemo chekuti inobva yangopinda mumakumbo avo.
Dzimwe nzira dzinosanganisira:
- Cancer masero angadzidza kugadzirisa mavo eDNA mapoka anokonzerwa nemamwe madhiragi chemo.
- Kanzera dzemawere dzinogona kukura "ganda rakasvibirira" kuitira kuti ataure, zvichiita kuti micheka yavo isanyanya kuderera, saka chemo haigoni kupinda.
- Kanzerini masero anogona kutora nzira yekuita kuti mushonga wacho urege kuita, zvichiita kuti urege kuita.
Izvi zvose zvakataura, zvakakosha kuziva kuti kana kenza yako iine chemorefractory, haisi mhosva yako-hapana chawakaita kana kuti hauna kuita icho chakaita kuti kenza isapindura.
Kuderedza Mikana Yako YeKenza Yako Kuva Chemorefractory
Kuti kuderedze mukana wekenza yemakorefractory, oncologists ndeyechokwadi mukupa varwere zvakanakisisa chemotherapy regimen kutanga. Izvi ndezvokuti kana kenza inova chemorefractory kune imwe chemo mishonga kana boka remishonga chemo, mikana yaro yekudzivirira kune dzimwe mishonga chemo yakakwirira.
Uyezve, oncologists vanowanzopa mishonga yemishonga chemo kuti inopedzera kenza isati yange isingadi-mune mamwe mazwi, kushandisa zvombo zvayo zvakasimba pakutanga.
Mukuwedzera pakusarudza mishonga chemo inoratidza mhinduro yakanakisisa inobva mukutsvakurudza, wako oncologist achacherechedza zvimwe zviitiko pakusarudza mishonga yako chemo, sehutano hwako hwepanyama kunze kwekenza yako, pamwe nehuwandu hwehuwandu hwetsvina ( parutivi migumisiro ) ye chemotherapy.
Shoko Rinobva
Paunenge uchiudzwa kuti une kenza yemakemikari inokonzera kuzvidya mwoyo uye inoshungurudza, hazvirevi kuti pane zvimwe zvingasara zvekuchengetedzwa kwekenza. Dzimwe nguva, zvinoreva kushanduka kune rimwe rakasiyana chemotherapy regimen kana rudzi rutsva rwekurapa zvachose.
Iva nechokwadi chokuti vatsvakurudzi vari kushanda vasinganeti kuti vawane nzira dzekugadzirisa mararamiro ekurapa kenza uye kuderedza chemotherapy resistance. Kunyanya, kurapwa kwekenza kunotungamira mune zvitsva, sezvinopupurirwa nekubuda kwezvirwere.
> Sources:
> America Cancer Society. (2017). Chemotherapy.
> Cleveland Clinic Chemocare. (2017). Chii chinonzi Chemotherapy?
> Krol M, Pawlowski KM, Majchrzak K, Szyszko K, Motyl T. Sei chemotherapy inogona kukundikana? Pol J Vet Sci. 2010; 13 (2): 399-406.
> National Cancer Institute. Tsanangudzo yekenza yakaramba.
> Sforza V. Clinical mugumisiro wevarwere vane chemorefractory mastatic colorectal cancer inobatwa ne trifluridine / tipiracil (TAS-102): imwe yeItaly inoshandisa hurongwa hwekushandisa tsitsi. ESMO Open. 2017; 2 (4): e000229.