T-Cell Lymphoma (CTCL) yakagadzikana ine lymphoma yeganda. CTCL inobva kuT-cells , rudzi rwe lymphocyte kana kuti white cell cell. CTCL haisi chirwere chimwe chete, asi boka rezviremera zvakasiyana-siyana zvinokonzera ganda rinosanganisira:
- Mycosis fungoides,
- Sezary syndrome,
- Reticulum cell sarcoma yeganda, uye
- Mamwe mazita emamwe mashoma anonzi lymphomas.
Lymphoma inowanzobatanidza lymph nodes .
Zvisinei, lymph cells kana lymphocytes zviripo munhengo dzose dzomuviri. Ganda iri nheyo inokosha yekuzvidzivirira kumagadzirirwo ezvirwere zvemuviri, uye mamwe T-masero anowanzoenda kune ganda kudzivirira kunorwara. Masero emukenza weT-cell lymphoma akacheka anotamirawo paganda. Zvizhinji zvezvinhu zve CTCL zvakabatana nematumbo, kana kukuvadzwa, zvinogadzirwa paganda.
Mucheka T-cell lymphoma inomiririra boka revanhu vashoma vari veNi-Hodgkin Lymphoma (NHL). CTCL inongoratidzira chete vanenge 1 mu 40 vatsva vanonzi vakawana NHL varwere.
Risk Factors
CTCL inobata varume vakawanda kupfuura vakadzi. Vanhu vane CTCL vanowanzova mumakumi mashanu kana makumi matanhatu avo. Vana havawanzovhiringidziki. Pakave nekuwedzera kunoshamisa kwehuwandu hwevanhu vanovhiringidzwa nekrisimasi yeganda pamusoro pemakore makumi matatu apfuura.
Hazvizivikanwi zvakawanda nezvechikonzero che CTCL. Kusiyana nedzimwe mhando dzemakiromita, hapana kushamwaridzana nemavhidhiyo anozivikanwa.
Kutsvakurudza kuri kuenderera mberi kuona kuti chii chinokonzera CTCL.
Zviratidzo
Zvokutanga zviratidzo zveganda lymphoma zvinosanganisira ganda rakaoma kana ganda, ruvara rutsvuku, uye kunhuwa. Izvo zvipfeko zvinowanzoonekwa munzvimbo dzakasara dzakapfekedzwa nenguvo. Vamwe vanhu vanogona kutanga vatarisa ruvara rutsvuku kana ruvara paganda. Zviratidzo izvi hazvirevi kuti i-lymphoma uye vanhu vazhinji vanowanzobatwa kuti vave nehuwandu hweganda musati vasati vambofungidzirwa.
Sezvo chirwere chacho chichifambira mberi, zvidzitiro zvitsvuku zvinogona kuve zvakakwirira, Izvo zvikwiriso zvakakwirira zvinonzi seplates. Mabheti angapedzisira ave matumire anogunun'una kana anokonzera. Muzvirwere zvakanyanya, zvironda zvinogona kukura pamusoro pezvizvi. CTCL inogona kupararira kune lymph nodes kana dzimwe nhengo. Vanhu vazhinji vane CTCL vane zviratidzo zveganda chete. Inenge 10 kubva muzana yematambudziko ekupedzisira-epakati inofambira mberi kukura matambudziko makuru.
Kuziva
Chigodo cheputi chinoda kuongorora CTCL. Muenzaniso wehupopi uchaongororwa pasi pe microscope kuti uone lymphoma masero. Mimwe miedzo yakawanda inosanganisira kuongororwa kwemaitiro ekuratidza lymphoma (immunohistochemistry) uye lymphoma magenjini anodiwa kuti awane rudzi rwe lymphoma. CT kuongorora kana zvimwe zviitiko zvekufungidzira zvingaitwa kuti uwane huwandu hwechirwere chacho.
Kurapa
Kurapa kweganda lymphoma kwakasiyana zvikuru nedzimwe nzira dzemuviri dzemuviri dzinobatwa. Nzira yako yekurapa inotarisana nehuwandu hwekugadzirwa kweganda, rudzi rweganda reganda, nekubatanidzwa kwe node kana dzimwe nhengo dzemuviri.
Mhando dzakawanda dzokurapa dzinoshandiswa:
- Chemotherapy agents anoshandiswa paganda
- Yese yeganda yemakristoni yakagadzirirwa chirwere-rudzi rwemishonga inonzi radiation
- Psoralen uye ultraviolet Mvura
- Ultraviolet B rays
- Bexarotene - zvose sejel uye mahwendefa
- Denileukin Difitox
- Interferon alpha
- Chemotherapy nemajojo kana mapiritsi
Chazhinji munguva pfupi yapfuura, US Food and Drug Administration (FDA) yakagamuchirwa mechlorethamine gel (Valchlor) nokuda kwekurapwa kweganda re mycosis fungoides, iyo yakawanda inowanzoitwa CTCL. Isati yagamuchirwa, mechlorethamine yakagamuchirwa chete nokuda kwekurapwa.
Shoko kubva
Rimwe boka reEuropean rezangano rekubvumirana rakasangana uye rakabudisa mazano avo pamusoro pehutano hwemarudzi akasiyana-siyana akasiyana-siyana uye matambudziko eTCTCL, achicherechedza kuti ganda-rinotungamirirwa kurapwa ichiri iro rakakosha pane imwe nguva yekutanga-gwara mycosis fungoides, uye kuti vazhinji varwere vane mycosis fungoides vanogona kutarisa mberi kune tarisiro yemazuva ose.
Zvinosuruvarisa, maitiro akadaro haasi akanaka kune vanorwara vane zvirwere zvakanyanya, ivo vakacherechedza, kunyange zvazvo kune nzvimbo yakasarudzwa yakanyanya yevarwere, kupona kwenguva refu kunogona kuwanikwa neallogeneic stem cell transplantation (alloSCT).
Kunyange zvakadaro, huwandu hwakawanda hwekufambira mberi hwakagadzirwa mumakore gumi apfuura maererano nekunzwisisa kwokuti mycosis fungicides uye Sezary syndrome inokura sei, saka pane tariro yokuti izvi zvichaita kuti kurapwa mberi kuvepo zvakare.
> Sources:
> Trautinger F, Eder J, Assaf C, et al. European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides / Sezary syndrome - Update 2017. Eur J Cancer. 2017; 77: 57-74.