Mukutsvakurudza kwechangobva kubudiswa, masayendisiti akawana kuti vanhu vane gastroesophageal reflux chirwere (GERD), zvikurukuru avo vane GERD zvinonzi Bharretts esophagus , vakashandura masero munzvimbo yavo ine zvigadziriswa tereomeres, kuguma kwekupedzisira muDNA michina. Zvakawanikwa zvekutsvakurudza uku zvinoratidza kuti kugoverwa kwepfupi kunogona kubvumira mamwe masero kugadziriswa nekenza kuti atore.
Maererano naDkt. Rhonda Souza, musongorori purofesa we mukati med medine kuti UT Southwestern, Tsvakurudzo inotsigira chikonzero nei zvichikosha kudzivirira reflux, nokuti kunyanya kufungisisa kwaunayo uye nguva refu iwe uine iyo, iyo inogona kukugadzirira iwe kuwana Barretts esophagus . Saka iwe unoda kudzivisa kukanganiswa ikoko.
Kana GERD iri kuenda isingateereri kana isingatariswi zvakanaka, mudumbu asidi inogona kuramba ichidzokorora ichienda kune inophagus. Apo izvi zvinenge zvichiitika, zvinogona kuita kuti masero akafanana nemasero eganda ari mukati mekushanduka kuve akaoma, mamwe masero asingagoni kushandiswa seaya anowanikwa mudumbu uye mumukumbo. Kana izvi zvikaitika, murwere anowanikwa ane chirwere chinonzi Barretts esophagus.
Adenocarcinoma yechipfupa, kenza inonyanyobatanidzwa neBarretts esophagus, iye zvino ndiyo kenza inokurumidza kukurumidza muUnited States, ine kuwedzera kanomwe mumatambudziko mumakore makumi matatu adarika, maererano neNational Cancer Institute.
Vatsvakurudzi vakafananidza tereekere kure uye basa re telomerase muzvinyorwa zvebiopsy kubva kuvarwere 38 vane GERD uye 16 varwere vanobata. Iyi mutsva wekutsvakurudza inoratidza kuti kupfurikidza asidi inoramba ichinyanya kugadzirisa masero esophageal inoita kuti vazoparadzanisa kakawanda kuitira kuti vadzokezve yakagadziriswa.
Zvisinei, nguva imwe neimwe masero achiparadzanisa, tereomere pamagumo eDNA anova maduku. Apo pavanenge vava kupfupika, sero rehembera haigoni kuparadzanisa, Dr. Souza akati.
Masayendisiti anofungidzira kuti kana masero asingachagoni kugovana, mamwe masero anogona kupinda mukati maro kuti agadzirire kurasikirwa. Uye iyo masero angave akawandisa kuunza kushivirira kweasiti inoita kuti vanyanya kuchinja kanha.
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Gastroesophageal Reflux Disease
Gastroesophageal reflux chirwere (GERD), iyo inozivikanwa seAic acid reflux, inowanikwa apo pasi shoma esophageal sphincter (LES) haisati yavhara zvakanaka uye mudumbu zviri mumvura zvinokonzera kumashure, kana kuti zvinoputika, mukati.Barrett's Esophagus
Bhuretta yaBarrett inzvimbo iyo inophagus, muscular tube iyo inotakura zvokudya nemateve kubva mumuromo kusvika mudumbu, inoshanduka kuitira kuti imwe yeripi iyo ichinjwe nehutachiwana hwakafanana nehwaiwanowanikwa mumatumbo. Izvi zvinonzi intestinal metaplasia.Esophageal Cancer
Esophageal adenocarcinoma ndiyo kenza inokura nokukurumidza munyika yekumadokero. Zvimwe zvipingamupinyi zvinokonzerwa nekenza iyi ndeye Gastroesophageal Reflux Disease (GERD) uye nharaunda yaBarrett.