CAH Zviratidzo Zvingaitwa Mimic PCOS
Paunofunga kuongororwa kwe polycystic ovary syndrome ( PCOS ), zvinowanzoita kuti chiremba afunge nezvekupedzisira-kubva congenital adrenal hyperplasia (CAH), zvakare. Ichi ndechokuti zvirwere zviviri izvi zvinowanzopa zviratidzo zvakafanana.
Kutevera-nguva dzose Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia iboka rakagara nhaka yezvirwere umo muroyiki wakakosha uripo mumuviri.
Genetic defect present panguva yekuzvarwa (kuberekwa) inokanganisa maitiro ezvinyorwa anodiwa kuti abudise zvakakosha adrenal cortex hormone.
Inenge 95 kubva muzana yemhosva dzeCAH dzinokonzerwa nekushaiwa kwe enzyme 21-hydroxylase. Muviri haugoni kuita zviyero zviviri zvakakosha adrenal steroid hormone-cortisol uye aldosterone-apo enzyme 21-hydroxylase inoshayikana kana kushanda pazasi. Izvi zvinoderedza kurema kwemahomoni, kudzivirira kukodzera kwakakwana kwealdosterone uye cortisol, uye adrenal cortex inotanga kuita androgens (varume steroid hormone), zvichiita kuti hune hukama hunhu hwevakadzi. Munharaunda iyi yekare yeCAH, muyero wemunyu unogonawo kuchinjwa zvakanyanya, zvichiita kuti kusawirirana kwe electrolyte, kupera mvura, uye chimiro chemoyo chichinje.
Kunyange zvazvo varwere vazhinji vanoonekwa kuti nguva pfupi mushure mekuberekwa, pane chirwere chechirwere ichi chinowedzera mushure mehupenyu, kazhinji pakuyaruka kana kuti kuchera-kunonzi kwete-classical kana kuti nguva yekupedzisira-CAH.
Vanhu ava vari kurasikirwa chete nemamwe enzymes anodikamwa pakugadzira cortisol. Chirongwa cheAldosterone hachina kugadziriswa, naizvozvo chimiro chechirwere chacho hachina kupfurikidza kupfuura chepenital fomu uye chinoratidza zviratidzo zvinowanzosiyiwa neCPOS, zvakadai se:
- Kutanga kufambisa kufambiswa kwebvudzi rinoputika
- Kunyoresa nguva yokuenda kumwedzi
- Hirsutism (isingadiwi kana kuti yakawandisa bvudzi)
- Nyaya yakasimba (pane chiso uye / kana muviri)
- Dambudziko rekubereka mu 10 kubva muzana kusvika ku15 muzana yevakadzi vechidiki vane CAH
Kuongororwa kweCAH
Congenital adrenal hyperplasia inoparidzirwa maitiro. Eastern European Jews (Ashkenazi) vane ngozi yakawanda yokuva nechirwere ichi, vachienzaniswa nevanhu vazhinji. Sezvo CAH iri chirwere chinokonzera kuzvidzora , vabereki vose vanofanira kutakura chirwere chinokonzera enzyme kuti chipfuure kumwana wavo.
Pamusana pehutachiona hwehutachiona hwechiitiko chacho, vanhu vazhinji vanoziva ngozi mumhuri yavo uye vanoita chiremba wavo kuziva nezvekudiwa kwekuongorora maitiro. Chiremba angashandisa urine uye kuongororwa ropa kuti aone cortisol dzisina kukwana kana mamwe mahomoni. Kuwedzera kweanorrogen mazinga kunogonawo kufungidzirwa paunenge uchitaridzika. Imwe nhoroondo yemhuri yakanyorwa uye yekuongorora mumuviri inobatsirawo kuti chiremba aite chirwere chakakwana.
Treatment Options
Kuberekwa kwepiritsi kunowanzobudirira mukuronga kunonoka kwemwedzi, kuderedza achena, uye dzimwe nguva kusasuruvara kwebvudzi kusina kuchena. Kana izvi zvisingabatsiri mukubata nezviratidzo, kana chiremba anonzwa kuti mapiritsi ekuberekwa asingakodzeri kwauri, iye angangokufunga kukupa chirwere chakakosha chechirotero.
Zvisinei, kurapwa hakusi kwoupenyu hwose.
Kune vanhu vane CAH yekare vane urombo husingawanikwi, a drug like fludrocortisone (Florinef) achachengetedza munyu mumuviri. Vana vacheche vanogamuchirawo mararamiro ekuwedzera (semapiritsi akapwanyika kana mhinduro), asi varwere vakwegura vane maitiro ekare eCAH vanodya kudya kwemanyu.
Mushonga chaiwo uye regimen inowanzosvika pakuziva kwechiremba wako uye unofanirwa nekuoma kwezviratidzo.
> Kwakabva:
> National Adrenal Diseases Foundation. Congenital Adrenal Hyperplasia (CAH).