Bhenfotiamine yomufananidzo wakaitwa nevanhu we thiamine kana B1. Thiamine is vitamini yakasvibiswa nemvura uye naizvozvo haisi nyore nyore kushandiswa nemuviri. Bhenfotiamine inogadzikana-yakasanganiswa uye ine nani kuwedzera uye inoshandiswa. Pakave nehumwe humwe uchapupu hwokuti benfotiamine inogona kubatsira kubvisa kukanganisika kwehutano hwehuga hwehuga hwakadai sekudzoka kwemazuva, nephropathy, uye neuropathy.
- Chii chinonzi Diabetes Retinopathy?
- Chii chinonzi Diabetes Nephropathy?
- Chii chinonzi Diabetes Neuropathy?
Benfotiamine yeDhiyabhesi Neuropathy
Bhenfotiamine yakawana dzidzo dzakawanda mumakore achangopfuura. Chinonyanya kukosha chekutsvaga kunosanganisira kushandisa benfotiamine sekurapa kwezvinetso zvechirwere cheshuga.
Kuwanda kwehutachiwana hwehuga hwehuga kunokonzerwa nehuwandu hweshuga yepamusoro (shuga yepamusoro yeropa) nekuda kwekudzivirirwa kweglucose yeropa kana kurwara kwechirwere kwenguva. Kuwedzera kweglucose muropa kunowanikwa mumasero emagetsi uye midzi midzi yeropa pamigumo, zvichikonzera kuora mune idzi nzvimbo zvinoguma zviratidzo uye zviratidzo zvezvinetso.
Nzira Nhatu KuMakuvara Kwemagetsi
Kune nzira dzakasiyana dzakasiyana dzinowanikwa mumuviri unogona kutungamirira kudiki shoma mumudziyo kukanganisa nekuda kwe hyperglycemia mune chirwere cheshuga.
- Pakupedzisira glycation endproducts (AGE)
- Protein kinase C (PKC)
- Hexosamine pathway activation
- Polyol nzira yekuita
Bhenfotiamine inoratidzika kuvhiringidza zvitatu zvezvizvi mune zvidzidzo zvechiremba. Imwe nyaya, yakabuda mubhuku rinonzi Nature Medicine munaFebruary 2003, yakanzi "Benfotiamine Blocks Three Major Pathways yeHyperglycemic Damage uye Inodzivisa Kuongororwa Kwezvekushaya Chirwere cheshuga" yakaratidza kuti benfotiamine yakadzivirira chirwere cheshuga chetachiona mumhuka dzebhishopi.
Yakawedzerwa Glycation End Products
Hyperglycemia inokonzera kukanganisa mumidziyo yeropa nemisungo yomuviri, iyo inotanga kuva dambudziko guru rechirwere cheshuga. Kukuvara kunowanikwa kana glucose yakawandisa muropa inopinda mumasero uye inogadzira chinhu chinonzi inozivikanwa seglycation endproducts (AGE) Ino inowedzera kwenguva. MAKORE anowanikwa mumidziyo yemaziso, itsvo, uye migumo. Izvo zvinowanikwa mune dzimwe mishonga yakakosha yeropa uye inotungamirira kumapanga ekugadzira uye atherosclerosis, zvichiita kuti zvirwere zvemoyo.
Chinonzi Benfotiamine
Zvidzidzo zvakaratidza kuti benfotiamine inoratidzika kubatsira kubatsira kudzivirira zvinetso zveuropathy, retinopathy, uye nephropathy nekudzivisa kuvaka-glucose mumidziyo. Izvi zvinoreva kuti kuitika kwehutachiona hwehutachiona kunogona kuderedzwa kana kudziviswa. Chirwere chechipatara chakaonekwa mubhuku reAdA reSaetetes muna 2003 rakaratidza kuti high-dose thiamine ne benfotiamine yakaratidzika kudzivirira microalbuminuria neproteinuria (mapuroteni mumuguta) mune ratsukashuga. Zvidzidzo zvakaitwa kuvanhu zvakaratidza kuti benfotiamine inoratidzika zvakare kunoderedza marwadzo europathic.
Nzvimbo Yemazuva Ano yeBenfotiamine
Bhenfotiamine achiri kuchipatara chekuedza. Dzidzo idzi dzakawanda dzave dzichiitwa pamakonzo akambomiswa kuti ave nechirwere cheshuga.
Mimwe miedzo yakasimba inodiwa kuti ione kana benfotiamine inoshanda nenzira imwechete kune vanhu vane chirwere cheshuga. Maitiro anobudirira haafaniri kuiswa, uye nguva yakareba yemigumisiro haisati yazivikanwa.
Kunyange zvazvo bhenfotiamine isiri yakarongedzwa nemaitiro eAmerica ehutano hwezvehutano panguva ino, inoratidzika seyo inogona kuva kurapa kunovhiringidza kwehutano hweshuga pasi pemugwagwa.
Kubvumirwa Kusinei Kwakarindirwa neDFA
The Food and Drug Administration (FDA) haisati yabvumirana ne benfotiamine kuitira kushandiswa kwevanhu. Pane nharo pamusoro pekuti iyo inofanira kuve yakanyorwa sei, ingava sekudya kwekudya kana vitamini.
Pane zvinonetsa pamusoro pekuchengetedzwa kwenyika kwenguva refu yekushandisa benfotiamine uye chii chinoreva kuvharwa kwakachengeteka. I-FDA inoda humwe uchapupu hunoratidza kuti benfotiamine inobereka mhinduro inowanikwa muidzo.
Gore rapera, benfotiamine yakaendeswa kune FDA sekuwedzera kwekudya, asi kugamuchirwa kuri kumirira panguva ino.
- FDA Mhinduro Yetsamba Kukumikidza kweBenfotiamine seDeary Supplement
Sources:
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> Huebschmann, MD, Amy G., Regensteiner, Ph.D., Judith G., Vlassara, MD, Helen, uye Reusch, MD, Jane EB "Chirwere cheshuga uye Advanced Glycoxidation End-Products." Diabetes Care 2006 1420-1432. 09 Mar 2007.
> Melpomemi >, MD, Peppa, Uribarri, MD, Jaime, naVlassara, MD, Helen. "Glucose, Advanced Glycation End Products, uye Zvinetso zveShuga: Chii Chitsva uye Chinoshanda." Clinical Diabetes 2003 186-187. 09 Mar 2007.
>> , >,,,,,,,,,,,,,,,,,,,,, , MD, Michaela, Koschinsky, MD, Theodor, Uribarri, MD, Jaime, Vlassara, MD, Helen uye Tschoepe, MD, Diethelm, "Benfotiamine Inodzivirira Macro- uye Microvascular Endothelial Dysfunction uye Oxidative Stress Kubva Kudya Kwakapfuma muGlycation End End Products mune mumwe munhu ane chirwere cheshuga cheshuga. " Diabetes Care 2006 2064-2071. 13 Mar 2007.
> "Zvinodhaka Kubata Matambudziko." Kubvira pakutsvakurudza kusvika kuChechokwadi. 2005. Vechiduku veSaabetes Research Foundation International. 18 Mar 2007.
> Hammes, Hans-Peter, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. "Benfotiamine Blocks Three Main Ways of Hyperglycemic Damage and Prevents Diabetes Retinopathy." Nature Medicine, 18 Feb. 2003 294-299. 18 Mar 2007.