Chikamu 2 che3
Sezvatakadzidza mune chikamu chimwechete, Chii chinonzi Post-Exertional Malaise, vanhu vane chirwere chisingaperi chine simba ( ME / CFS ) vanoona kazhinji kacho kunoshamisa kwezviratidzo zvichienderana nekuedza. Ichi chiratidzo chinoshamisa chechirwere uye icho vatsvakurudzi vave vachiedza kuverenga kwemakore. Tine zvakawanda zvatinodzidza pamusoro pechiratidzo ichi, asi tinoziva kuti zvakawanda zvisiri izvo zvepanyama zvinokonzerwa ne post-exertional malaise (PEM).
Zvisizvo Zvisingabatsiri
Vatsvakurudzi vakaona kusagadzikana kwepabonde mune zvimwe zvinhu, kusanganisira maitiro ezvirwere zvemuviri, iyo inonzi central nervous system, uye yemwoyo. Kusvika ikozvino, ivo havana kukwanisa kugumisa kuti izvi zvisiri izvo ndizvo zvinokonzera (s) zvePEM. Kubvunzurudzwa kwegore ra2014 rezvinyorwa zvezvokurapa zvakatsanangurwa zvakasiyana-siyana zvakashandurwa zvirwere zvekuzvidzivirira mazvirwere muna ME / CFS, zhinji dzazvo dzaisungirwa kuita zvekuita uye PEM. Izvi zvaisanganisira:
- Chimwe chinopindurwa mhinduro mubatsiri (iyo chikamu chemuviri wechirwere chemuviri unobatsira majekesheni akajeka kubva mumuviri wako),
- Kuwedzerwa kwehutachiona hwehupombwe (rudzi rwemagadzirirwo emagetsi) pamwe chete nevarombo antioxidant mhinduro,
- Kushandurwa muzvirwere zvemuviri maune immune.
Mamwe matsvakurudzo (Morris 2014) akaongorora kusakanganiswa kunobatana nechirwere chinonzi adenosine triphosphate (ATP), iyo inomiriro yemagetsi. ME / CFS inofungidzirwa kuti inobatanidza neremera risina kukwanisa kuumba ATP pamutambo we mitochondrial.
(Mitochondria zvivako mumasero ako zvinoshandura mishonga muAATP.)
Chidzidzo chegore ra2015 kuburikidza nekombiyuta yemuenzaniso wechirwere (Lengert) yakatarisa zvakaderera mazinga eAtP, izvo zvinowanzoita kuti kuwedzerwa kuwanda kwesero rekufa. A chain chain kutanga neAAA pasi yakatungamirira ku immunological dysregulations nekushushikana mupfungwa, maererano nemuenzaniso.
Vanotsvakurudza vanoti kudzvinyirirwa kakawanda kwakaita kuti mamiriro acho akaipire. Muna 2012, pepa rinotsvaga mitochondrial basa uye ME / CFS (Morris) rakakurukura zvinhu zvakasiyana-siyana, kusanganisira:
- Yakagadzirira immuno-inflammatory pathways,
- Kuwedzera kwehuwandu hwepro-inflammatory cytokines ,
- Kuwedzerwa kwehukliya yenyu-kB,
- Kubhaira mumitochondrial mabasa, kusanganisira kuderera kweAtP.
Vatsvakurudzi vakatsanangura kuti izvi zvinogona kunge, zvichida chikamu, zvinokonzera kupera kwemitochondrial, izvo zvinoreva kuti kana muviri uchitsvaga simba (nenzira yeAATP), simba rinongova risipo.
Imwe yedzidzo yegore ra2015 yakashandisa nzira yekutsvaidza inonzi near-infrared spectroscopy kuti ienzanise kushandiswa kweokisijeni munguva yekunyorovedza. Kuenzaniswa nevanhu vane hutano muboka rekutungamirira, vatori vechikamu ne ME / CFS vakawanikwa vachichinja kusina kuitika mukati memhepo yakakosha ye hemoglobin (puroteni mumasero matsvuku eropa anotakura okisijeni kumasero ako) mushure mokushanda.
Chero kusanganiswa kwezvikonzero izvi zvinogona kuve zvakakonzera kupa PEM. Kunyange zvakadaro, vatsvakurudzi vane basa rakawanda mberi kwavo. Vamwe vatsvakurudzi vakaratidza kuti zvimwe zvisiri izvo zvinogona kushandiswa sechinangwa chokucherechedza chinangwa cheM ME / CFS apo vamwe vanotenda PEM inogona kuva nzira inobatsira kuti vanachiremba vaone kuoma kwechirwere.
Chinonyanya kukosha, patinodzidza zvakawanda pamusoro pezvinoitika mumuviri panguva yePEM, patinenge tava pedyo nekunzwisisa maitiro ekurapa.
Dzidza zvimwe
Sources:
Lengert N, Drossel B. Nyaya yezvinyorwa. 2015 Jul; 202: 21-31. Mu-silico kuongorora kusagadzikana kwebasa mu myalgic encephalomyelitis / chronic fatigue syndrome.
Miller RR, et al. Zvinyorwa zvemishonga yekushandura. 2015 Mbudzi 20; 13: 159. Submaximal kuongororwa kuongororwa ne-near-infrared spectroscopy mu myalgic encephalomyelitis / chronic fatigue syndrome varwere vachienzaniswa neutano hwakanaka: kuongororwa kwakaitwa nyaya.
Morris G, Maes M. Medical Hypotheses. 2012 Nov; 79 (5): 607-13. Kuwedzera kwenyukireya-kB uye kurasikirwa kwep53 inzira dzakakosha mune myalgic encephalomyelitis / chronic fatigue syndrome (ME / CFS).
Morris G, Maes M. Metabolic utano hwehupfungwa. 2014 Mar; 29 (1): 19-36. Mitochondrial dysfunctions mu myalgic encephalomyelitis / chronic fatigue syndrome yakatsanangurwa neyakagadziriswa immuno-inflammatory, oxidative uye nitrosative stress pathways.
Nijs J, Nees A, et al. Ita maitiro ekudzidzira mafungiro. 2014; 20: 94-116. Kushandurwa kwemuviri wemuviri kunobatsira muvarwere vane chirwere chisingaperi chine fatigue syndrome / myalgic encephalomyelitis: kugadziriswa kwekuongorora mabhuku.