Ipapomegranate , iyo yaimboonekwa seyekare, ikozvino yakakurumbira zvikuru. Pomegranate juice inowanikwa munenge imwe neimwe yezvokudya muNorth America.
Asi imwe nhau yakabudiswa muSeptember 1, 2006, magazini yeAmerican Journal of Cardiology inoratidza kuti mapomegranate anogona kusangana nemishonga inowanzopiwa.
Mumwe murume ane makore 48 aitora ezetimibe (Zetia®) 10 mg pazuva uye rosuvastatin (Crestor®) 5 mg imwe neimwe zuva kwemwedzi 17.
Zvose mishonga inoshandiswa pakukwirira kwecholesterol.
Akatanga kunwa pomegranate juice (200 ml kaviri pamusi wevhiki nevhiki) uye vhiki nhatu gare gare, akabatwa kune imwe nguva nekurwadziwa kwehudyu uye yakakura serum creatine kinase level (138,030 U / L, kazhinji <200 U / L). Zvose izvi zviratidzo zve rhabdomyolysis, chirwere chakakomba chinokonzera kuputsika kwemasikironi emasumbu uye zvinogona kutungamirira kushaya mafungiro.
Rosuvastatin ndeyeboka remishonga inonzi HMG-CoA reductase inhibitors, kana kuti 'statins'. Muchero weGrapefruit unozivikanwa kuti uwedzere njodzi yechipin-induced myopathy, asi kusvikira zvino, paiva nemashoko mashomanana pamusoro pekuti kana gome yemapomegranate ingawedzerawo mungozi.
Pomegranate juice nemuchero wemazambiringa, zvose zviri zviviri zvinozivikanwa kudzivirira cytochrome P450 3A4 enzyme systems mumatumbo. Nokuvhiringidza ma enzyme, maji anokwanisa kuwedzera ropa remishonga yakawanda.
Zvichida Mapomegranate-Zvinodhaka Zvinodhaka
- Antiarrhythmics - Amiodarone (Cordarone®), disopyramide (Norpace®), quinidine
- Calcium channel blockers - Felodipine (Plendil®), nicardipine (Cardene®), nifedipine (Procardia®), nimodipine (Nimotop®), nisoldipine (Sular®)
- Statins - Atorvastatin (Lipitor®), lovastatin (Mevacor®), simvastatin (Zocor®)
- Immunosuppressants - Cyclosporine (Sandimmune®, Neoral®), tacrolimus (Prograf®)
- Protease inhibitors - Saquinavir (Fortovase®)
Zvisinei, gome rinogonawo kusangana nemishonga kwete pane urongwa urwu.
Izvozvo zvinodhaka ezetimibe uye rosuvastatin hazvifungidziri kuti zvakaputsika ne cytochrome P450 3A4.
Kubva pane uchapupu hushoma huripo pamusoro pekugona kushandiswa kwezvinodhaka, zvinokosha kuti iwe utaure nachiremba wako kana iwe uri kutora mishonga uye uri kufunga nezvekunwa pomegranate juice.
Sources:
Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Nzira dzekomegranate juisi pavanhu cytochrome p450 3A (CYP3A) uye carbamazepine pharmacokinetics mumakonzo. Dhiyabhorosi Metabolism uye Kugadziriswa. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Inhibitory migumisiro yemiti yemichero pane basa reYP3A. Dhiyabhorosi Metabolism uye Kugadziriswa. 34.4 (2006): 521-3.
Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis inobatanidza nepomegranate juice yekushandisa. American Journal of Cardiology. 98.5 (2006): 705-6.
Zvinonzwisisika: Mashoko anowanikwa pane ino yepaiti inoitirwa zvinangwa zvekudzidzisa chete uye haisi kutsiva mazano, kuongororwa kana kurapwa nechiremba ane chiremba. Hazvirevi kuvhara zvose zvinogona kumira, kushamwaridzana kwezvinodhaka, mamiriro ezvinhu kana zvinetso zvakashata. Iwe unofanirwa kutsvaga kurapwa nokukurumidza mune zvehutano kune chero hutano hwehutano uye bvunza chiremba wako usati washandisa mamwe mushonga kana kuita shanduko kune regimen yako.