Orencia (abatacept) yakagamuchirwa neU.S. Food and Drug Administration (FDA) musi waDec 23, 2005 semishonga yekupedzisira yekurapa zviratidzo nezviratidzo zve rheumatoid arthritis . Orencia akabatana nedzimwe nhatu dzeDMARD dzezvinyorwa panguva yekuderedza kufambira mberi kwekugadziriswa kwemuumbi, kusanganisira tumor necrosis chinokonzera zvinopesana (anti-TNF drugs):
Simponi (golimumab) uye Cimzia (certolizumab pegol), mavirizve TNF blockers, vakabvumidzwa gare gare.
Orencia inogamuchirwa kuti ive yakarongeka kuti iite zvakasimba rheumatoid arthritis varwere vasina kugadzikana kupindura kune rimwe remishonga-inoshandiswa zvinodhaka (DMARDs) iyo inowedzera kune vanopikisa veNTF vanosanganisira:
- Rheumatrex (methotrexate)
- Arava (rakasara)
- Plaquenil (hydroxychloroquine)
- Azulfidine (sulfasalazine)
Orencia Inoshandiswa Sei
Saizvozvowo naRicicade (infliximab), Orencia inopiwa sechirwere chinoputira (IV). Orencia kunyange iyo inoshandiswa kupfuura maminitsi makumi matatu, kusiyana ne infliximab iyo inotarisirwa pamusoro pemaminetsi maviri.
Kutevera kutungamira kwekutanga, Orencia inopiwa pamasvondo maviri ne4, ipapo masvondo mana mushure mazvo. Orencia inogona kushandiswa se monotherapy (yoga) kana inogadzikana nedzimwe DMARD dzisiri dzeNATF dzinokonzerwa nehuwandu hwehuwandu hwehutsanana pamwe chete.
Kubva munaJuly 2011, kuumbwa kwekudzivirira-injectable yeOrencia kwakagamuchirwa neDFA.
Migumisiro Yechikamu Yakabatanidzwa naOrencia
Zvimwe zvikanganiso zvinosanganisira asi hazvirevi kune:
- zvinokonzera kugadzirisa izvo zvisingawanzove kutyisa upenyu
- utachiona
- Matambudziko epumusoro (zvikurukuru kune varwere vane chirwere chepachirwere chinokonzera kupora maperembudzi uye marignancies)
Chokwadi Chinofanira Kufungisisa Asati Waedza Orencia
Mari yeOrencia inosanganisira kuongorora kwayo inogona kunge yakawanda kudarika injectable TNF antagonists adalimumab uye etanercept asi pasi pe infliximab. Orencia akaratidza kungobatsira zvishoma kana achishandiswa ari oga saka zvakanakisisa zvakatemwa kune imwe DMARD yakadai se methotrexate kana vamwe kuti vabudirire zvakaguma.
Kusvikira pane zvimwe zviitiko zvekurapa naOrencia, vamwe vanachiremba vanodzichengetedza kune varwere vakakundikana kana vaviri kubva kune vatatu vanopikisa TNF (vachienzaniswa nezvisingabatsiri migumisiro kana kusakwanisa kubatsirwa). Izvi zvinodhaka zvemaArthritis zvave zviri pamusika kubva etanercept yakatangwa muna 1999 uye inoratidza chikonzero chakanaka chekubatsira-panjodzi.
Orencia vs. Anakinra
Anakinra inowanzoshandiswa kurapa rheumatoid arthritis nekuda kwekudiwa kwayo majekiseni ezuva nezuva uye kubatsirwa kwakakwana kunofananidzwa nevanopikisa veNTF vanodzivisa basa reN TNF (cytokine kana mutumwa pakati pemasero). TNF inhengo inobatsira zvikuru mukukonzera kuputika nekukuvara mu rheumatoid arthritis.
T masero anoshandawo pakuita kuti zviratidzo zviratidzo nezviratidzo zve rheumatoid arthritis. Orencia inovhara chiratidzo muropa iro rinodikanwa kumasero eT kuti aite kukanganisa.
Kineret (anakinra) inodzivirira i-cytokine IL-1 iyo inobatsira mukukanganisa kweropa iro riri chikamu cherheumatoid arthritis.
Mhinduro yakapiwa naScott J. Zashin, MD, purofesa mupurezidhendi mudzidzisi paYunivhesiti yeTexas Southwestern Medical School, Division of Rheumatology, muDallas, Texas. Dr. Zashin zvakare ari kuenda kuchiremba muPresbyterian Hospitals yeDallas uye Plano. Iye ishamwari yeAmerican College of Physicians uye American College of Rheumatology uye nhengo yeAmerican Medical Association.