Autoantibodies ndiwo mapuroteni anokonzerwa nemasimba emuviri wako. Iwe unogona kunge unoziva kuti maitiro ezvirwere zvemuviri wako akagadzirirwa kurwisa zvinotyisa semavirusi uye mabhakitiriya anoita nzira yawo mumuviri wako. Asi iyo autoanbody inoshandura kurwisa kwayo pane chinhu chisina kunaka: Panzvimbo yekurwisa vanopinda kune dzimwe nyika, autoantibodies vachikanganisa kurwisa zvikamu zvemuviri wako.
Pavanoita izvi, autoantibodies inokonzera kuvhiringidza nekukuvadza kune chero hurongwa hwemuviri hunoitika huri kurwisana. Izvi zvinokonzera mune izvo zvatinoti " autoimmune chirwere " -kureva, "auto" zvinoreva "iwe pachako." I-autoantibodies inotangira zviratidzo zvechirwere chaicho chiri pachena.
Sei Mutumbi Wenyu Uchiita Autoantibodies?
Izvozvo hazvisi pachena. Genetics inogona kuita basa iri, sezvinoita zvinhu zvakasikwa. Asi vatsvakurudzi havana kutsanangura kuti nei vamwe vanhu vane mararamiro akafanana uye / kana zvimwe zvinokonzera zvakatipoteredza zvinotanga kuita autoantibodies uye zvinoenderera mberi kukudziridza chirwere chemotokari, asi vamwe vasingaiti. Muchirwere chechiliac , somuenzaniso, muviri wako unopindira kuwedzerwa kweprotheni ye gluten muzvokudya iwe unodya nokuumba autoantibodies izvo zvinoenderera mberi kurwisa rwonzi rwemukati mako.
Iye zvino, huwandu hwevanhu vane chirwere chechiliac hutakura chimwe chezviviri zvemajeni izvo zvinoita kuti zvivepo.
Asi izvi zvinonzi chirwere chechiliac zvipenyu zvakanyanya, uye chikamu chiduku cheavo vane majeni anotanga kuita autoantibodies uye vanoramba vachikura chirwere ichi. Saka, zviri pachena kuti pane chimwe chinhu chiri kutamba chinoita kuti muviri wako utange kugadzira autoantibodies. Kutsvakurudza kuri kuenderera mberi kuti uone kuti "chimwe chinhu" ichocho chinogona kuva chei.
Ndezvipi Zvimwe Ndinofanira Kuziva Nezve Autoantibodies?
Mamwe maantiantibodies anorwisa imwe nhengo-somuenzaniso, autoantibodies mune chirwere chechiliac kurwisa musikana muduku, autoantibodies mukudzivirira kwechirwere chetachiona kurwisa chirwere chetachiona, uye autoantibodies muurudzi rwechipiri chirwere cheshuga chinokonzera masero anokonzera insulini mupascreas.
Izvi zvikamu-specificantiantibodies zvinowanzoendesa kune zviratidzo zvakanyatsojeka zvinogona kubatsira chiremba wako kuti aone zvakajeka. Semuenzaniso, pane mazana emakiromita ezvirwere zvepachiyero izvi , asi zviratidzo zvinowanzoonekwa, zvinosanganisira zvinetso zvekudya uye anemia, zvinogona kupa ruzivo rwekubatsira pakuongorora.
Zvimwe autoantibodies ndizvo zvinonzi "systemic," izvo zvinoreva kuti vanorwisa munzvimbo dzakasiyana-siyana mumuviri wenyu wose. Izvi zvinogona kuita kuti zviratidzo zvakawanda, zvakadai sekurwadziwa kwemajoka uye rashes, zvigadzirise mamiriro acho ezvinhu zvakaoma kunzwisisa.
Somuenzaniso, zvingava zvakaoma kutaurira musiyano pakati pezvirwere zvega autommune lupus uye fibromyalgia, izvo vanachiremba vanotenda hazvisi mamiriro ezvinhu ega. Kuti zvibatsire kuita kuti kuongororwa, vanachiremba vanogona kurayira kuongorora kwekutsvaga ropa vachitsvaga autoantibodies inonzi anti anti-nuclear antibodies, kana ANA. Izvi ndezvokudzivirira zvirwere izvo zvinorwisa zvikamu zve nuclei dzako, uye anenge anenge wese ane lupus anoedza kuve akanaka kwavari, achienzaniswa nediki shoma chete yevaya vane fibromyalgia.
Sources:
Arbuckle MR et al. Kuvandudza autoantibodies kusati kwaitika kliniki ye systemic lupus erythematosus. New England Journal of Medicine . 2003 Oct 16; 349 (16): 1526-33.
Dönmez S et al. Chirwere chemoto chinonzi autoimmune rheumatic chinosangana zviratidzo mu fibromyalgia varwere uye maitiro avo pamusana pokuzvidya mwoyo, kuora mwoyo uye kufungidzira: kuenzanisa. Clinical uye Ongororo Rheumatology . 2012 Nov-Dec; 30 (6 Suppl 74): 65-9.
Fujii T. Direct uye asinganzwisisiki pathogenic nhengo dze autoantibodies mu systemic autoimmune zvirwere. Allergology International . 2014 Dec; 63 (4): 515-22.
Hu ZD et al. Autoantibodies mu-pre-clinic autoimmune chirwere. Clinica Chimica Acta: The International Journal of Clinical Chemistry . 2014 Nov 1; 437: 14-8.