Chirwere Chezviratidzo Zvinoputika
Mixed connective tissue disease (MCTD) chirwere chinogadziriswa nehutachiona hune humwe hutatu hutachiona hwezvirwere- systemic lupus erythematosus , scleroderma , uye polymyositis.
Cause
Chikonzero cheMCTD hachizivikanwi. Inenge 80 muzana yevanhu vanoonekwa kuti vane MCTD vakadzi. Chirwere chacho chinokanganisa vanhu vane makore mashanu kusvika makumi mapfumbamwe nemakore makumi mapfumbamwe nemazana makumi masere ekuberekwa kwepamusoro pakati pevechiri kuyaruka kana vanhu vane makore makumi maviri.
Panogona kunge kune ruzivo rwemagetsi asi hauna nhaka yakananga.
Zviratidzo
Zviratidzo zvekutanga zvezvirwere zvinokanganisa zvirwere zvakanyanya kufanana nezviratidzo zvinosangana nedzimwe zvirwere zvinogadzirisa zvirwere uye zvinogona kusanganisira:
- Kuneta
- Kusuruvara kwepfungwa kana utera
- Joint pain
- Low-grade fever
- Raynaud's phenomenon
Zviratidzo zvishoma zvinowanzobatanidzwa neMCTD zvinosanganisira zvakanyanya mapirymyositis (kunyanya kuchinja mafudzi nepamusoro maoko), kurwadziwa kweArthritis, aseptic meningitis, myelitis, chirwere cheminwe nezvigunwe, hovha huru, kurwadziwa kwepamuviri, neuropathy yemagunha ekutenderera mukati, kuoma kunomedza, kufema kwekufema, uye kurasikirwa kunzwa. Mapapu anokanganisa kusvika ku75 muzana yevanhu vane MCTD. Inenge 25 kubva muzana yevarwere vane MCTD vane maitiro eutsvo.
Kuziva
Kuongorora zvirwere zvakasiyana-siyana zvinogona kuoma zvikuru. Zviratidzo zvezvinhu zvitatu-systemic lupus erythematosus, scleroderma, uye polymyositis-kazhinji hazviitiki panguva imwe chete.
Pane kudaro, vanowanzokura imwe pashure peimwe nguva.
Kune, zvisinei, zvimwe zvinhu zvina zvinogona kuratidza kufungidzirwa kweMCTD panzvimbo pane mumwe munhu anogadzirisa chirwere chemashuga:
- Kunyanya kuwedzera kwe-anti-U1 RNP (ribonucleoprotein) muropa
- Kushayikwa kweimwe nyaya inowanzoenderana ne systemic lupus erythematosus, yakadai sezvinetso zveputsvo uye pakati pehutano hwematambudziko
- Yakanyanya arthritis uye mishonga yechakamusoro (isina kufanira mu systemic lupus kana scleroderma)
- Raynaud's phenomenon, uye maoko akadzora (asingazivikanwi ne systemic lupus)
Nepo kuvapo kwe-anti-U1 RNP ndiyo inonyanya kusiyanisa iyo inokweretesa kuongororwa kweMCTD, kuvapo kwechirwere ichi muropa kunogona kutangira zviratidzo.
Kurapa
Kurapa kwehutano hwakakanganiswa hutachiona hunotungamirirwa kuronga zviratidzo uye kutarisa zvinokonzera zvakanyanya zvechirwere, zvakadai sekubatanidzwa kwomuviri. Somuenzaniso, chirwere chepachimona chepachimhosva chinofanirwa kurapwa nemishonga inopesana nehutachiona. Zviratidzo zvinopisa zvinogona kubva pane zvinyoro kusvikira kune zvakanyanya, uye kurapa kwaizofanira kusarudzwa zvichienderana nekuoma. Nokuputika kwakanyanya kudarika, NSAIDs kana kuti chirwere chakashata- corticosteroids chinogona kupiwa. Kuenzanisa kunokonzera kupisa kunogona kudikanwa neyortic cortiosteroids. Kana pane chikwata ichibatanidzwa, zvirwere zvekudzivirira muviri zvinogona kupiwa.
Outlook
Kunyangwe nekuongorora kwakarurama uye kurapa kwakakodzera, kufungidzira kunogona kuoma kuumba. Kunyatsoita murwere kunoenderana nhengo dzipi dzinobatanidzwa, kuoma kwokuputika, uye kuwedzera kwechirwere. Maererano neCleveland Clinic, 80 muzana yevanhu vanopona makore gumi mushure mekunge vaongororwa neMCTD.
Kufanirwa kweMCTD kunowedzera kuipa kune varwere vane unhu hwakasungirirwa kune scleroderma kana polymyositis.
Zvakakosha kucherechedza kuti kune nguva yakawedzerwa iyo isina zviratidzo, kunyange pasina mushonga weMCTD.
> Sources:
> Bennett R. Anti-U1 RNP Zvirwere muMixed Connective Tissue Disease. Kusvika pari zvino.
> Firestein GS, Kelley WN. Kelleys Textbook of Rheumatology . Philadelphia, PA: Elsevier / Saunders; 2013.
> Gunnarsson R, Hetlevik SO, Lilleby V, Molberg Ø. Mixed connective tissue disease. Maitiro Akanakisisa & Tsvakurudzo Clinic Rheumatology . 2016; 30 (1): 95-111. doi: 10.1016 / j.berh.2016.03.002.
> Mixed Connective Tissue Disease. Cleveland Clinic.