Tsanangudzo: Microsporidiosis chirwere chinotarisana chinokonzerwa nemhando dzakasiyana dze fungus unicellular, microsporidia . Chirwere ichi chinogona kukanganisa chirwere chepamuviri uye zvimwe zvikamu zvemuviri, zvinowanzotaridzika kune vanhu vane zvirwere zvakakomba zvemasimba, zvakadai seavo vane HIV . Kazhinji pane zvisiri, utachiona hunoitika apo CD4 count yemunhu inowira pasi pe100 masero / mL.
Kunyange zvazvo microsporidiosis inowanzobatanidzwa nehutano hwezviratidzo zvemimba, kusanganisira chirwere chakanyanya uye kuparara , mamwe marudzi e microsporidia anogona kuchinja mafungiro, mapapu, sinuses, maziso uye pakati penheyo system, zvakare.
Pakutanga yaifungidzirwa kuva protozoan pathogen, kuongorora kwezvemagetsi gare gare kwakasimbisa microsporidia kuti ive nhengo yeumambo hwefungi. Ikozvino pane 14 microsporidia marudzi anozivikanwa kuti anobata vanhu.
Prevalence Rates
Uhu huripo hunoratidzika huri kuratidza kuti kupararira kwe microsporidiosis pakati peAIDS vane utachiona hweHIV huri pasi, inenge 1.6%. Zvisinei, zvimwe zvidzidzo zvakaratidza kuti kupararira kwehutachiona hwe microsporidial kune avo vakazotevera-nhanho vanhu vane zvirwere zvisingaperi kana zvirwere zvekurwara zvakanyanya, zvakapoteredza 39%.
Modes of Transmission
Kudengenyeka kwe microsporidia kuchiri kusati kwakanyatsojeka, kunyange zvazvo kuongororwa kunoratidzira kuti fungal spores inogona kuiswa, inhaled, kana kunyange kupfurikidza nehutachiona hwemucho mucosal (seziso).
Muhutachiona, spores inowedzera mukati me cytoplasm (kureva, mukati memvura) yemasero ane utachiona, nemamwe marudzi-akaita seEncephalitozooan intestinalis- anokonzera chirwere chakanyanya, asi vamwe- seEngphelitozoon cuniculi- inokonzera mafungiro uye nheyo yenheyo.
Zviratidzo zve Microsporidiosis
Kunyange zvazvo vanhu vane hutachiona hwezvirwere vanogona kuonekwa kuti vane microsporidiosis, uye yakawanda, chirwere chinoonekwa kune avo vane AIDS .
Kana ichibata chirwere chepamuviri, chirwere chakanyanya uye kuparara kunowanzoonekwa, kazhinji kana kusina fivha, kuvhiringidzika kana kuti fivha huru. Kazhinji, zviratidzo hazvizivikanwi kubva kune zve cystoisosporiasis uye cryptosporidiosis .
Zviratidzo zvinogona kunge zviri kure (zvichienderana nemhando ipi ye microsporidia inotapukirwa) uye inogona kusanganisira:
- Kushungurudza, kubhururuka uye kushanda kufema
- Atypical urinary tract infection
- Muscular simba uye kurwadziwa
- Musoro wemusoro uye migraines
- Kuona maziso, kuchena kwekunzwa, kurwadziwa kweziso, kunyanya kuputika
- Nasal kusanganiswa, kurwadziwa kwechivi
- Inflamed gallbladder
Kuongororwa kwe Microsporidiosis
Kuongororwa kwe microsporidiosis kunotsigirwa nekuratidzwa kwezvipatara zvechipatara uye zviratidzo zvechirwere; pre-test probability (subjective test of the possibility of infection in one); uye kuongororwa kwemasese, urini, miviri yenyama, kana zvimwe zvirwere mumuviri.
Transmission electron microscopy, kunyange zvazvo inodhura, inogona kupa tsanangudzo yekujekesa nekujekesa zvakajeka microsporidia spores. Zvimwe, gramu yakaita kuti microscope ishandiswe inobatanidzwa mukuziva kushandiswa kweporesi.
Genetic PCR (polymerase chain reaction) miedzo inowanika kujekesa microsporidia, asi inenge yakazara mukutsvakurudza chete.
Kurapa kwe Microsporidiosis
Sezvo microsporidiosis inowanzobatanidzwa nehutachiona hwekudzivirira muviri, inorayirwa kuti kusanganisa antiretroviral therapy (kadhi) inofanira kuitwa sechikamu chekutanga chekuita.
IAzole drug, albendazole, inogona kushandiswa kushandiswa mukurapa microsporidia, zvikurukuru nemhando dzakadai seE E. intestinalis , kunyange zvazvo dzimwe dzidzo dzakaratidza kuti hadzina kubudirira mukurapa mamwe mhando. Itraconazole inowanzoshandiswa neAlubendazole mune zvirwere zvinoparadzirwa (kureva, kana yapararira kupfuura kwepakutanga nzvimbo yekutaura).
Iyo antifungal fumagillin inoonekwawo sechinhu chinogona kushandiswa, pamwe nedzimwe dzidzo dzinofunga kuti dzine zvakanakisisa mumatambudziko eE bienusi marwere .
Zvisinei, hazviwanikwi nokuda kwekushandiswa kwehurongwa muUnited States. Matsipa epamusoro fumagillin anowanikwa kune zvirwere zveziso, kunyange zvakakurudzirwa kushandiswa pamwe ne albendazole therapy.
Ndapota, cherechedza, kuti kushandiswa kwe albendazole ikozvino hakusi kukurudzirwa panguva yekutanga kwemwedzi yekudzivirira nekuda kwemhuka yekuongorora inoratidza chiitiko chekuberekwa kwekuberekwa kwekuberekwa. Ikozvino pane zvisingakwanisi deta maererano nekushandiswa kwe albendazole muhutumbi hwevanhu.
Kudzivirira kwe Microsporidiosis
Sezvo etiology (chikonzero) che microsporidiosis haisi zvachose chakajeka, inorayirwa kuti vanhu vanopinda mumuviri-vanopikisa vanotevedzera maitiro akafanana e cystoisosporiasis, izvo zvinosanganisira kudzivisa mvura isina kunyorerwa, nyama yakasviba, kana nyama yakasvibirira yegungwa.
Kutumidzwa: mi-kro-spo-rid-ee-OH-suhs
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