Hodgkin Lymphoma

Chirongwa cheHodgkin Lymphoma

Lymphoma mutsara unobuda muboka remasero machena anonzi lymphocytes. Mumuviri wako unotsigamira pamhando dzakasiyana-siyana dze lymphocytes kuti uite mabasa akasiyana muzvirwere zvemuviri. Aya lymphocytes ndiwo masero anokura mumatanho, akafanana akaita tadpoles kuva matatya. Uye, sezvo kenza inogona kukura mumarudzi akasiyana e-lymphocytes uye pamatanho akasiyana-siyana ekubudirira kwavo, mhando dzakasiyana-siyana dze lymphoma dzinogoneka.

Hodgkin lymphoma (HL) uye kwete-Hodgkin lymphoma (NHL) ndiwo mapoka makuru maviri e-lymphoma . HL inonziwo chirwere cheHodgkin, uye mazita maviri anorondedzera chirwere chimwechete-hapana chakadaro sehosha yeHodgkin isiri lymphoma. Mumwe chiremba anonzi Thomas Hodgkin akawana HL muma1800, uye lymphoma ine zita rake kusvikira nhasi.

Hodgkin Lymphoma: A Cancer of the Lymph Nodes

HL inowanzotanga mune lymph nodes , sezvinoita maitiro akawanda.

• Kutsungirira nekuwana rubatsiro Paunenge uine Hodgkin Disease

• Kubereka uye Kubata Paunorarama neHodgkin Lymphoma

Mumwe nomumwe wedu ane mazana emakirini, izvo zviduku, nhengo dzakaita semhete dzinobatsira kuchengeta kutarisa mumuviri wemutumbi unonzi lymph.

Chii chinonzi lymph? Zvakanaka, kana iwe uchifungidzira kuisa ropa rako kuburikidza nekanyoro kadiki, masero eropa uye mapuroteni makuru aizoramba ari mumucheka apo mvura inenge ichipfuura. Iyo yewaini yakafanana neyine lymph. Masero mumakirini ndeye nyaya yakasiyana. Masero machena emuviri omunhu anoenda kune lymphatic system kuita mabasa echirwere chemuviri. Maseu akachena anotenderera muine lymph, uye vazhinji vavo vanogara mumakirinikodhi.

Lymph nodes kugara zvakarongeka mumaketani emakirini-lymph-fluid akazara, kushanda semagadzirirwo emasumbu, kana chekuona.

Lymph node imwe neimwe inosvina mvura inogamuchirwa kubva kune midziyo ye lymph iyo inoparadza imwe nzvimbo yomuviri.

Dzimwe nguva vanhu vanoziva lymph nodes semakumbo pasi peganda, kana izvo zvinonzi zvinorembera zvinyuchi zvingaguma kubva kune utachiona. Kazhinji nguva, lymph node ine utano kana husingapinduri inoenda isingaoneki. Uyezve, mamwe lymph nodes ari mukati mukati memuviri, pedyo nemwoyo, pakati pemapapu, kana mukati mukati mechimbuva, kunaya uye kuchenesa lymph fluid kubva munhengo dzomukati uye maviri. Munzvimbo idzi, vangave vasingaoneki kwechinguva, kunyange kana vakwatuka kana kuti vachikura.

Node iri kukura kubva kuHodgkin lymphoma inowanzokwira mumucheto wepamusoro wemuviri, mumakumbo emakumbo emutsipa, pasi, kana mukati mebhokisi.

Chii Chinokonzera Hodgkin Lymphoma?

Masayendisiti haazive chinonyanya kukonzera Hodgkin lymphoma. Kune zvimwe zvinozivikanwa zvinokonzera njodzi, asi kuvapo kwechinetso chekutengesa hakuiti nenzira ipi neipi yekuti HL ichakudziridza, uye hapana chikonzero chekuvadza ndicho chinokonzera apo HL inokura.

Zvimwe zvinokonzera njodzi zvinosanganisira utachiona hunokonzera mono, kana kuti mononucleosis, iyo inonzi Epstein-Bar virus. Nhoroondo yemhuri iinewo mungozi, asi haazivi kuti sei kana sei; izvo zvinoreva kuti, panogona kugoverwa mazai ezvemhuri anoita kuti mhuri dzive nehuwandu hweHL, kana zvichida vanhu mumhuri imwechete vane zvirwere zvakafanana zvehuduku izvo zvinovaisa pangozi yeHL. Kuva nechirwere chekudzivirirwa mumuviri kunowedzerawo mukana weHL. Kuzvidzivirira kwakadaro kunokonzerwa neHIV / AIDS, zvimwe zvirwere zvakasiyana-siyana, kana kubva kumishonga inoshandiswa kudzivisa kupindirana kwezvirwere zvemuviri.

Ndiani Anowana Hodgkin Lymphoma?

Hodgkin lymphoma haisati iripo kudarika NHL yakawanda, inongororai chete inenge 10 muzana yezvose zvinokonzera lymphoma. Izvo zvinogona kuitika kune vose nevakuru, uye pane mazera maviri ezera remakore:

• Vachiri kuyaruka uye vechiduku vane makore gumi nemashanu kusvika ku40
• Vakuru vakwegura vanopfuura makore 55

Saka, kunyange zvazvo HL isingawanzoitiki, kana inogona kuita sokuti vanhu vane makore makumi maviri nemakumi makumi maviri vanowana zvirwere zvakanyanya, uye zvichida nemhaka yechikwata chekutanga chezera.

Iyo yakasiyana sei neHas-Hodgkin Lymphoma?

Munhu mumwe nomumwe ane HL anogona kunge ane nyaya yake kuti ataure. Muzhinji, zvisinei, Hodgkin lymphoma iri duku, boka rakasiyana-siyana reymymmas kupfuura NHL. HL inomuka mumasero eB, kana B-lymphocyte, sezvinoita mhando dzakawanda dzeNHL. Zvisinei, kusiyana neNHL, HL ine zvishanu chete tsika dzinoziva subtypes (zvakawanda pane iri pasi apa); NHL ine zvakawanda zvadzo.

HL neNHL vanosiyanawo nenzira iyo vanobuda nayo uye vanopararira kuburikidza nemhando dzakasiyana-siyana dzemuviri. HL yakawanda kwazvo yekutanga uye kupararira mune imwe nzira, nenzira yakarongeka-kubva kune lymph node kuenda kune lymph node. Kunongowanikwa kazhinji uye munguva yekupedzisira chirwere ichi chinoita kuti HL inopinda ropa uye inowanda kupararira. Muzviitiko zvizhinji zveNHL, inofungidzirwa kubva pakuenda-kuenda kuti nodes akawanda muzvikamu zvakasiyana zvemuviri inogona kuve yakabatanidzwa, kusvikira ichiratidzwa zvimwe.

Zviratidzo zveHodgkin Lymphoma

Vanhu vane HL vanogona kusimbisa zviratidzo zvakasiyana, asi chiitiko chinowanzozivikanwa pakuongororwa chinowedzera lymph node (s) uye hapana chimwe chinhu.

Lymph nodes dzinogona kuwedzerwa mumutsipa, kupindira, kana kugomera, zvichiita kuti bundu risina kurwadza , kana mukati mebhokisi.

• Ndezvipi Zvirwere Zvechirwere Muvanhu Vane Hodgkin Zvirwere?

• 8 Zviratidzo nezviratidzo zveHodgkin Lymphoma

Pashoma pfupi, avo vane HL vanogona kuora muviri, fivha , kuchenesa, kana kudonhedzera kutuka usiku, pamwe chete zvinonzi B zviratidzo .

Chimwe chinhu chisingawanzoziviki asi chinoratidza HL kurwadziwa kunobatanidza nekushandisa doro. Masayendisiti haazive chaizvoizvo nei izvi zvichiitika, asi zvinogona kunge zviripo nekuwedzera kwemidziyo mukati memishonga inokonzera lymph nodes mukupindura doro.

Kuongororwa kweHodgkin Lymphoma

Chiremera chinoparadzirwa chisingatauri hachifaniri kuregererwa. Zvisinei, zvinokonzera lymph node kuwedzera zvakanyanya , uye vazhinji vavo havasi kenza. Kana munhu akambofungidzirwa kuti lymph node isiri itsva, pane nguva yakawanda yekumirira nguva kuti ave nechokwadi chokuti haibvumi kune chimwe chikonzero. Lymph nodes inowanzove yakanyunguduka kubva kune hutachiona uye zvimwe zvinokonzera kudarika lymphoma.

Lymph Node Biopsy

Apo HL inenge ichifungidzirwa, lymph nodes inogona kuve yakagadzirwa. Bhiopsy inzira inoshandiswa nayo muenzaniso wezvisikwa kubva kune lymph node kana zvimwe zvikamu zvemuviri uye kutumirwa ku laboratory kuti iongorore uye kuongororwa. Zvichienderana nenzvimbo ye lymph node, nzira inogona kunge yakajeka kana kuti zvishoma nezvimwe inobatanidzwa, asi mune imwe nguva iyo inowanzoonekwa sokuvhiyiwa kwechidiki. Mhosva inogona kuitwa muchipatara chekuvhima kunze kana muchipatara.

Mune chikonzero chekunyanyisa, iwe unopiwa chirwere chekushaya maitiro kunzvimbo yako kuitira kuti iwe urege kunzwa kurwadziwa panguva iyo. Ganda riri pamusoro pekunyunyuta lymph node (s) rinovhurwa nechingwa chiduku, uye rimwe rymph nodes kana zvishomanana zvacho zvinotorwa. Iyo yakatemwa inobva yatorwa yakavharwa. Iko inotora inotora maminitsi makumi matatu kusvika ku45, uye iwe unogona kudzokera kumusha nguva pfupi mushure mekuita.

Zvimwewo, apo lymph nodes kana dzimwe nzvimbo dzinoshusha dziri mukati mukati memuviri, nzira ye biopsy inogona kusanganisira kuongorora kwemuviri uye kufungidzira kunotungamirira nheyo kunzvimbo chaiyo yezvinhu zvinokanganisika. Chiremba anokwanisa kudarika kushandisa sora kuti awane sampu, iyo inotorwa uye inotumirwa kunechirwere chekuongorora.

Chimiro chakanaka chinoshuva ndechokuti dzimwe nguva zvinoshandiswa, kunyanya sechinhu chekutanga apo pane kunetseka kuti node mumutsipa inogona kubatanidzwa nekenza yemukati nemutsipa. Chimiro chesenzi chinoshuva, zvisinei, hachipi sechinhu chakanaka chemuenzaniso wekunakidza bhiopsy yekutanga kuongororwa kweHL.

Dzimwe nguva dzimwe nzvimbo dzakadai semafuta emapfupa dzinoshandiswa, asi izvi hazviwanzo chikamu chechiitiko chekuongorora kwekutanga HL.

Dambudziko reRopa

Kuyera ropa kwakafanana nehuwandu hwekuverenga ropa kana CBC inosanganisira kupikisa kushandura maitiro eropa emhando dzakasiyana-siyana kuti aone kana nhamba yako inowira mumutambo wakatarwa kana kuti usina kukwana. Zviwanikwa hazvisi zvakananga kune HL. Dzimwe nguva dzimwe zviratidzo kubva muropa zvinogona kushandiswa kuwedzera ruzivo rwunopindirana nekutaura. Uye kuongororwa kwehutachiwana hwehutachiona huriwo chikamu chekutanga chekuongorora kwebazi.

PET Scans uye Imaging

PET kuongorora pamusoro pemakore achangopfuura kwave kwakakosha pakugadzirwa kwekutanga kweHodgkin lymphoma. PET kuongorora kunogonawo kubatsira kutaurira musiyano pakati pemakumbo anoshanda uye mafirimu anoramba ari mumuviri mushure mekunge munhu ane HL apora. Mirayiridzo inobva kuNational Comprehensive Cancer Network inopa PET / CT kuti ive yekutanga yekugadzirisa uye yekupedzisira kupindura mhinduro kune varwere vane HL .

PET kuongorora uye CT kuongorora kune marudzi maviri akasiyana- siyana ekufungidzira anowanzoitwa pamwe chete kuitira kuti mufananidzo wakajeka wematomu unowanikwa kuburikidza neC CT apo simba rePET rinosungirirwa kuti rione nzvimbo dzezvirwere zvinopenya. Muto mubhokisi, kana mediastinum, inowanikwa zvakajairika mukirasi HL paPET / CT.

Basa rePET rinoenderera mberi nekushanduka, uye kune chido chikuru mukati mekuita PET kuongorora, umo iwe unogona kuona mhinduro yauri kupiwa kune chirongwa chinotangira usati warongerwa. Muzviitiko zvakawanda, jweta rinenge riri kunze panguva yakanakisisa yePET kuongorora uye zvinoshandiswa pakuchinja kwerapi.

Marudzi eHodgkin Lymphoma

Kune marudzi mashanu makuru eHL ayo anogona kuonekwa ane. Chikoro cheHodgkin lymphoma ishoko rekare rinoshandiswa kurondedzera boka remazana mana anowanzobatanidzwa pamwe chete anowedzera zvinopfuura 95 muzana zvezviitiko zvose zveHL munyika dzakabudirira. Pakati pemarudzi mashanu makuru, mazana mana okutanga ndiwo classical HL:

Nodular Sclerosing Hodgkin Lymphoma (NSHL)

• Rudzi rwakakurumbira rweHL; nhoroondo ye 60 muzana kusvika 70 muzana yeHL zviitiko zvose
• Zvinowanzowanikwa kune vakadzi uye zvinowanzobata vanhu vaduku
• Inonyanya kubata node mumutsipa kana mumakumbo, kana mukati mebhokisi

Mixed Cellularity Hodgkin Lymphoma (MCHL)

• Imwe mhando yakawanda yeHL, inotora 15 muzana kune 30 muzana yezviongorori
• Zvinowanzowanikwa munyika dzinokura
• Inobata vanhu vezera ripi zvaro
• Zvichida kuisa mimba pane yakanyanya kufanana nodular sclerosing zvakasiyana, uye zvisingabviri kusanganisira nodes mukati memuti
• Ane utsinye, asi anonyatsoporesa

Lymphocyte Depleted Hodgkin Lymphoma (LDHL)

• Nzira isingawanzoitiki yeHL iyo inongogadzira chete 1 muzana yematambudziko
• Kuonekwa kune vanhu vakwegura uye kazhinji kunoonekwa mune imwe nzvimbo yakakwirira; uyewo inowanikwa kune avo vane utachiona hweHIV

Lymphocyte-rich Classical Hodgkin Lymphoma (LRCHL)

• Kazhinji subtype; nhoroondo dze 5% kubva kune 6 muzana yezviongorori
• Inobata vanhu kunyanya muma30s kana makumi mana
• Vakawanda vanoonekwa kuti vari mumatanho ekutanga; Mhinduro yekurapa yakanakisisa
• Kazhinji inowanikwa mune dzimwe nhengo shomanana dzemaitiro; inoitika muhafu yepamusoro yemuviri.

Icho chinodzinga imwe nzira imwe chete yisiri yeclassical HL :

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)

• Iye zvino inofungidzirwa sehuwandu hweHL hwakasiyana nedzimwe mhando dziri pamusoro
• Nhoroondo dze 4% kusvika ku5 muzana yezviongorori
• Masero masikirini akafanana neNHL
• Chipatara chirwere chakafanana nemhando ye lymphocyte-yakawanda ye classical HL, inobatanidza lymph nodes kazhinji mumutsipa uye mumakumbo

Ndezvipi zvinoratidzira?

Nenzira yakawanda, HL inofananidzwa seimwe yenzira inoporesa uye inoporesa yekenza yeropa painobatwa mumatanho ayo okutanga, uye inogona kuporesa kunyange mumatanho ekupedzisira. Zvisinei, panewo mhaka dzinodzoka mushure mekurapa uye / kana izvo zvakaoma kubata.

Nhamba pamusoro peHL kurapa mazinga uye kuponeswa kwemitemo haisi nyore nguva dzose kunzwisisa kana kushandisa kune mumwe chete; saka nekushanda nachiremba kuti anzwisise kusarudzwa kwekurapa uye prognoses inokosha.

Kurapa kweHodgkin Lymphoma

Kana iwe wakabatwa uine HL uye uri kushamisika nezvekusarudza kwako kurapwa, taura nachiremba wako pamusoro pechando chako uye izvo zvinorevei. Chemotherapy kana radiation inogona kukurudzirwa, asi chii chakakunakira iwe chichatsiva pane yako chaiyo HL, mhaka, makore ako, hutano hwako hwose, nezvimwewo.

Dzidza zvakawanda nezvekurapa Hodgkin lymphoma .

Kana iwe uchiri kurapwa, iva nechokwadi chekuona chiremba wako kana ukacherechedza chero chinhu chipi zvacho chitsva chine chokuita nemamiriro ako ezvinhu kana uri nemigumisiro, mamwe acho anogona kugadzirirwa mishonga. Kana iwe uine mubvunzo pamusoro pemamiriro ako ezvinhu kana kuti uri kutarisirwa sei, usambozeza kutaura nachiremba wako zvakare kana kutsvaga mutsara wechipiri.

Shoko Rinobva

Iwe unofanirwa kufungidzira kugadzirira kusangana nachiremba wako kana uine zviratidzo zvinoshungurudza kana zviratidzo. Dzimwe nguva lymph node inoputika inongova lymph node inoputika, iyo inokosha kuchengeta mupfungwa. Asi kusazvidza lymph node inoramba ichibhururuka kunogonawo kureva mikana isina kuwanikwa yekuona nekukurumidza nekurapa.

Kana iwe kana munhu waunoda akawanikwa ane Hodgkin lymphoma, zvinowanzoita kuti uchinetseke uye zvishoma zvichishamisika. Kuita manzwiro emarudzi ose e-lymphoma uye kurapwa kunogona kuva basa rinotyisa. Paunenge uchiverenga, iva nechokwadi chokuti zvitubu zvako zvinoreva Hodgkin lymphoma zvakananga, kwete kwete lymphoma zvachose.

Pano, isu tinopindira kutsanangura zvinhu zvichienderana nesayenzi yakanakisisa, asi nguva dzose muchiChirungu. Ongorora kakawanda uye pane chimwe chikamu chekufamba kwako kwechirwere, uye shandisa zvimwe zvezvipo kune varwere vakaita seAmerican Cancer Society uye Leukemia & Lymphoma Society.

Dzimwe nguva zvinogona kubatsira kutaura kune mumwe munhu ave achishandisa Hodgkin lymphoma uye zvose zvinorwara uye kurapwa zvinosanganisira. Kudzivirira kupedza mazano, misangano, uye kunyange nhepfenyuro yevanhu ndeye nzira dzakanakisisa dzekubatana nevamwe vanogona kugoverana nematambudziko ako kana kuva nezvakaitika zvakafanana nemanzwisisiro.

> Sources:

> America Cancer Society. Ndezvipi zvinokonzera ngozi kune Hodgkin chirwere?

> Hutchings M. Inobatsira sei PET / CT kubatsira mukusarudza chirwere chevarwere vane Hodgkin lymphoma? Hematology Am Soc Hematol Dzidzo Yedzidzo . 2012; 2012: 322-7.

> Townsend W, Linch D. Hodgkin's lymphoma kuvanhu vakuru. Lancet . 2012; 380 (9844): 836-47.