Kuita Kuti Ganda Rako uye Immune System Soshanda Pamwe Chete Kuti Uchengetedze Utano
Langerhans masero (LCs) ari pachiganda ( epidermis uye dermis ) yekupemha, kudya uye urogenital maturakiti. Vanogonawo kuwanika kune mamwe maitiro akadai se-lymph nodes, kunyanya kana chirwere cheLangerhans cell histiocytosis (LCH) chinosanganiswa.
LCs inobatsira kukudzivirira nekuchengetedza maantigenji ane ngozi (chero chinhu chinokonzera maitiro ezvirwere zvemuviri kuti azvidzivirire mazviri) kupinda mumuviri wako.
Maitiro eLangerhans Maselo Anoshanda Sei?
Akawanikwa nemudzidzi wezvokurapa wechiGermany ane makore 21, Paul Langerhans, muna 1868, Langerhans masero aripo mumativi ose epidermis uye nhengo dzemhuri ye dendritic. Masero eDendritic masero omusingaoneki anopa antigens kumagadzirirwo ezvirwere uye anowanikwa yose mumuviri wose. LCs masero eDendritic ari paganda uye sezvo masero e-dendritic anoshanda zvakanyanya pakushandura masimba ezvirwere zvezvirwere kusvika pakuvapo kwezvirwere uye zvimwe zvinhu zvekunze, ganda rinoita kuti zvive nehutachiona.
LCs pakutanga yaifungidzirwa kuva chikamu chehurongwa hwemagandanga uye kungocherechedza maitiro ezvirwere zvezvirwere kumasiteni. Pane kudaro, tsvakurudzo yakawana kuti LC inoderedza mararamiro eganda kuhutachiona nekuputika munzira mbiri dzakasiyana-siyana:
- Nokudzivirira ganda rako kubva kune utachiona.
- Nokukurudzira kugadzirisa kweeergicia.
Langerhans masero anotumira maitiro anoshandiswa-masero emumunondo anenge masero e-T uye masero e-B pakarepo mushure mekuona chero chero rudzi rwehupenyu muganda.
Mune masero emuviri anodzivirira vatadzi vakadai sebhakitiriya uye mavairasi uye vanorwisa kukuvadzwa sekucheka uye kuputika.
Nzvimbo yeganda inoramba ichiongororwa neLCs pamamiriro ezvinhu asina kuchengeteka uye masero emumunini anotumirwa kuti adzose mashoko pamusoro pevamwe vapanduki vokunze. Mumuviri unosunungura simba guru remasero ekuvhiringidza kuti varwe nevashamisi nekugadzira zvinokonzera kugadzikana kana kuumba zvisikwa zvitsvuku kudzivirira kubva kune utachiona.
LCs uye Ganda Mamiriro
Kutsvakurudza kutsva kunoratidza kuti Langerhans masero anokwanisa kuziva nekurwisa zvirwere kubva kumamiriro akakomberedza, nokudaro kudzivirira utachiona. Izvi zvinoona kuti LCs inobatanidzwa mukuzvidzivirira kwezvirwere zvezvirwere zvakasiyana-siyana zvinogona kuita kuti zvive zvinangwa zvekudzivirira muviri.
Izvi zvinogonawo kuchinja zvakanyanya kunzwisisa maitiro anokonzerwa nezvinetso zveganda zvakadai se:
- Psoriasis : Mamiriro ezvinhu umo masero eganda anogadzira uye anogadzira zviyero zvinopfurikidza nehumwe hutsvuku, huchinyoro uye mashizha akaoma.
- Lupus : Chirwere chinoputika chinokonzerwa kana maitiro ezvirwere zvekuzvidzivirira achizvidzivirira.
- Kenza yechuti : Chimiro chinonyanyozivikanwa cheCancer muU.S., chinoratidzwa nekukura kusina kuchena kwemasero eganda.
Ikoko kunogonawo kuve nekugadzirwa kwemishonga yepicopi inoshandiswa kuburikidza neganda (Epicutaneous vaccination) iyo inotarisa kuisa LCs zvakananga muganda nemaantijeni. Kutsvakurudza kwave kutarisa mishonga inopiwa kuburikidza nemugariro-kupwanyika kweganda kuitira kuti kudzivisa kukura kwemaranoma , rudzi rwakakomba rwekenza yenguruve.
Chii chinonzi Langerhans Cell Histiocytosis (LCH)?
Langerhans cell histiocytosis (LCH) iboka revashoma, idiopathic dambudziko rinogona kukanganisa ganda, mapfupa nedzimwe nhengo.
Kuwandisa kwemasero akafanana neLCs kunobudiswa mune chirwere ichi, zvisinei, LCH masero anoratidza zvakasiyana, hematopoietic (ropa remasero) kubva kune chirwere.
Sources:
Langerhans P. Uber die Nerven der menschlichen Haut. Varoki Arch [A] 1868; 44: 325-337.
Seo N., et al. Percutaneous peptide vaccination via corneum barrier-kuvhiringidzika murine ganda kuti vaongorore tumor immunoprophylaxis. Proc Natl Acad Sci USA 2000; 97: 371-376.
Yagi H., et al . Induction yeTherapeutically inobatsira cytotoxic T lymphocytes muvanhu ne percutaneous peptide vacunization. Cancer Res 2006; 66: 10136-10144.