Dhiyabhorosi Yedu yeDhiyabhorosi-Yakagamuchirwa
Cymbalta (duloxetine) iri FDA-inogamuchirwa nokuda kwe fibromyalgia , kuora mwoyo, chirwere cheshuga chirwere chepfungwa, uye marwadzo asingagumi mushuloskeletal.
Chibvumirano chavo cha2008 chakaita kuti ive yechipiri chemishonga inobvumirwa kuporesa fibromyalgia. Romu generic inowanikwa muUnited States
Cymbalta nedzimwe mishonga inogamuchirwa, Lyrica (pregabalin) uye Savella (milnacipran) , inonzi inorapwa mitsara yekutanga ye fibromyalgia.
Izvozvo zvinoreva kuti vanorumbidzwa vasati vapiwe mamwe mishonga. Vanoshanda zvakanaka kune vamwe asi kwete kuvanhu vose. Kune vamwe vanhu, vanokonzera migumisiro yechirwere iyo inogona kuva nengozi kana isingafadzi kukwanisa kuita kuti vanhu vaende kwavari. Kune vamwe, havangoshanda zvakanaka.
(Izvi hazvisi zvakasiyana neCymbalta.) Hapana bumbiro rimwe chete rinobatsira isu tose nechirwere ichi.)
Chii chinonzi Cymbalta
Cymbalta inorondedzerwa seSNRI kana serotonin norepinephrine reuptake inhibitor. Zvinorevei izvo?
Serotonin uye norepinephrine vane neurotransmitters (makemikisi mumakemikari ako.) Serotonin inobatanidzwa mukurara-kupera uye kunorwadza. Norepinephrine inokubatsira kuti unzwe wakangwarira uye unofarira pamwe nekuita basa mukuyeuka.
Zvose izvi zveeurotransmitter dzinotendwa kuti dzinoparadzaniswa mu fibromyalgia, zvinoreva kuti isu hatina zvakakwana kana zvatiinazvo hazvishandiswi zvakakodzera kuburikidza nehutano hwedu. Chero nzira, tinogona kushandisa zvakawanda zvezvo.
Cymbalta nedzimwe SNRIs hazviwedzeri serotonin uye norepinephrine kuhutano hwedu, asi dzinoita kuti zviwanikwe kwenguva yakareba, iyo inowanzova nemigumisiro yakafanana nekuwedzera mamwe. Kuti uite izvozvo, vanononoka pasi purojekiti inonzi reuptake umo masero mashoma ari muuropi ako anobviswa zvachose serotonin uye norepinephrine mushure mekunge yashandiswa kutumira mashoko kubva kune imwe neuron kune imwe.
(Zvakafanana neurotransmitter inoputika yakasara yakarongedzwa mushure mokuzarura mail yako.) Kuchengetedza neurotransmitter nguva yakareba kwenguva refu kunoita kuti uropi hwako hushandise zvakajeka.
Cymbalta yeFibromyalgia
Mamiriyoni emakiriniki anongoratidzira anoratidza kuti Cymbalta inogona kuderedza kurwadziwa kwe fibromyalgia, zvose pamwe uye pasina comorbid depression. Zvidzidzo zvakare zvinoratidza kuti mushonga uyu unoramba uchibudirira kwegore rimwechete.
Vatsvakurudzi havanyatsonzwisisi kuti mushandisi uyu unoshanda sei. Zvisinei, chidzidzo che2015 (Wang) chinoratidza kuti kunoderedza zvirwere zvinorwadza zvinokonzerwa nehutano hwehutano (neuropathy.) Imwe tsanangudzo yehutachiona hwe fibromyalgia ndeyokuti inosanganisira chirwere chepurovhesi mumatambudziko maduku pedyo necheputi peganda rako. Kana ichokwadi, zvinogona kunge zvakaita kuti Cymbalta inowanzobudirira pakurwadziwa kwedu.
Muchidzidzo ichocho, Cymbalta yakaratidzwa kuderedza marudzi maviri ekurwadziwa anowanzoitwa fibromyalgia: hyperalgesia uye allodynia. Hyperalgesia ndiyo iyo "inotenderera ivhu" rekutambudzika kwedu, nepo allodynia inorwadziwa nezvinhu izvo zvisingaiti kuti zvinokonzera marwadzo, zvakadai sekumanikidzika.
Dosage
Iyo yakakurudzirwa Cymbalta dosage is 60 mg, inotorwa kamwe pazuva. Inowanzotanga pa 30 mg pazuva uye yowedzera kusvika ku 60 mg mushure mekunge vhiki.
Nhamba yakakwirira kudarika iyi haitendi kuti inobudirira kune fibromyalgia, uye inobatanidzwa nehuwandu hwemigumisiro yemigumisiro.
Vanhu vanoda kumira kutora ichi chirwere vanofanira kutaura nachiremba wavo pamusoro penzira yakakodzera yokuderedza zvishoma nezvishoma; kumira kamwe kamwe kune ngozi. Chiremba wako anogonawo kukwanisa kukubatsira kuderedza zviratidzo zvekuregera.
Migumisiro Yechiri
Cymbalta inosanganiswa nemitambo yakawanda inogoneka. Izvo zvaunofanira kuudza chiremba wako pakarepo zvinosanganisira:
- Allergic reactions (rash, itching kana mikoko, kutuka kwechiso, miromo kana rurimi),
- Ropa kudzvinyirira kuchinja,
- Kuvhiringidzika,
- Kutsiva uye / kana kurasikirwa kwekuenzanisa,
- Kutaura nekukurumidza, manzwiro anonakidza, kana kunze kwekudzivirira,
- Kukurumidza, kusagadzikana kwepfungwa,
- Fever,
- Hluccinations kana kurasikirwa kwekubatana nechokwadi,
- Kugumburwa,
- Kurwiswa, kurutsa,
- Kuzviuraya pfungwa kana mamwe mafungiro anochinja,
- Mvura ine rima,
- Kubuda ropa kusina kujairika kana kuputika.
Zvimwe zvikamu zveCymbalta izvo zvisingawanzodi kurapwa zvinosanganisira:
- Chiratidzo chisina kunaka,
- Appetite inoshanduka,
- Kuchinja mune zvekuita zvepabonde kana kushanda,
- Headache,
- Kuwedzera kwekutuka,
- Nausea.
Is Cymbalta Yakakodzera Here?
Kana iwe uchida kuedza Cymbalta, taura nachiremba wako. Iva nechokwadi chekucherechedza zvakanyatsonaka zvinobudirira uye zvinotarisa uye tarisa mune zvingave zvakakanganisika kusangana nemimwe mishonga iwe uri kutora.
Iyo pfungwa yakanaka, nemishonga ipi neipi, kuti ive nerwendo rwemigumisiro inogoneka inobatsira. Iwe unogona kuda kurega vanhu vari pedo newe vachiziva nezvemigumisiro yakakomba, yakadai sekugumburwa, kurasikirwa kwekubatana neicho, kana kuzviuraya, kuitira kuti vazive zviri kuitika, kana zvichiitika.
Sources:
Arnold LM, et al The clinical journal of pain. 2009 Jul-Aug; 25 (6): 461-8. Kuenzanisa kwehutano nekuchengeteka kwe duloxetine pakurapa fibromyalgia kune varwere vane kurwisana pasina hukuru hwekuora mwoyo.
Choy EH, et al Clinical rheumatology. 2009 Sep; 28 (9): 1035-44. Kuchengetedzwa uye kushivirira kwe duloxetine mukurapa kwevarwere vane fibromyalgia: kuongororwa kwakaitwa data kubva kumakirini mashanu emakiriniki.
Hauser W, et al. Arthritis research & therapy. 2014 Jan 17; 16 (1): 201. Kudzokorora kwemishonga yemapirmistra mu fibromyalgia syndrome.
NIH Mabhuku NO. 04-5326
Uceyler N, et al. Ubongo. 2013 Jun; 136 (Pt 6): 1857-67. Dhiyabhorosi inorwara kune vane varwere vane fibromyalgia syndrome.
Wang CF, uye al. Anesthesia uye analgesia. 2015 Aug; 121 (2): 532-44. Maitiro emunharaunda uye emuitiro we duloxetine muAllodynia uye hyperalgesia achishandisa randa rekukanda incision pain model.