Inorable compound inoderedza kusangana kwehuputi hwehuputi hwehutano
Synvisc (hylan GF 20) inonzi flux viscous yakabva kune chinhu chinonzi hyaluronan (sodium hyaluronate). Hyaluronan inoberekwa zvakasikwa mumuviri kuti ibatsire kuisa majoini. Chimiro chinowanika muSyvisc chinoitwa kubva kune gelatinous zvinhu zvakatorwa kubva kumagumbe ehuku.
Synvisc inoshandiswa mune imwe nzira yehutano inozivikanwa seviscosupplementation iyo iyo inoshandiswa muzvikamu zvakabatana kuti ibatsire kuwedzera kugadzirwa.
Drug Overview
Synvisc injections inogamuchirwa kuitira kurapwa kweasteoarthritis yemabvi kune vanhu vakakundikana kupindura kune mamwe maitiro ekuchengetedza, kusanganisira analgesics uye kusina zvinodhaka.
Synvisc inowanikwa mune injini mbiri-milliliter zvakananga mumabvi akabatanidzwa. Haisati yabvumirwa kune chero chibatanidzwa kunze kwebvi. Synvisc inowanzopiwa sechikamu chezvikamu zvitatu zvinopiwa mavhiki ose. Kuti zvive nemigumisiro yakanakisisa, synovial fluids mumakumbo emabvi anowanzobviswa vasati vasvika mujisi rekutanga.
Pane imwe svondo re Synvisc, inozivikanwa saSyncc-One, iyo inoshandiswa seyechete, matanhatu-milliliter kupfura.
Synvisc yakagamuchirwa kuti ishandiswe neU.S. Food and Drug Administration musi waAugust 8, 1997. Synvisc-One yakagamuchirwa neDFA musi waFebruary 26, 2009. Zvikamu zvakanyanya zvinowanzobatanidzwa ne Synvisc zvinosanganisira:
- Urombo, kuzvimba, kana kuoma mumabvi akaiswa
- Joint effusion ("mvura mumabvi")
- Joint nerve pain
- Rash kana mikoko
- Fever
- Nausea
- Headache
- Chizutu
- Muscle makampu
- Kuneta
Zvizhinji zvezviratidzo izvi zvinononoka kuenzanisa zvakasimba uye zvichagadzirisa pachavo pasina kurapwa. Kana imwe yezviratidzo ichi ichiramba ichiwedzera, fanira chiremba wako pakarepo sezvo ichi chichigona kuva chiratidzo chetachiona kana kuti kurwara.
Kubudirira kweSyncc mukuraira Knee Surgery
Chirwere chemakiriniki chakaitwa kuti chiongorore kubudirira kwe Synvisc kune vanhu vane osteoarthritis yakasimba yeimwe kana mabvi maviri. Vatori vechikamu vanosanganisira 56 vakadzi uye varume makumi mashanu nemakumi mashanu nemasereji ava nemakore makumi matanhatu nematanhatu. Mumwe nomumwe akanga akundikana kuwana ruzamu pamwe nemamwe maitiro asingashandisi anonzi inflammatory drugs (NSAIDs) kana kuti cortisone shots .
Panguva yekutongwa, mumwe mugoveri akagamuchira matatu injini ye Syn Synthc kwevhiki imwe chete. Kuongororwa kwakaitwa pane imwe, mitatu, mitanhatu, 12, 15, uye 18 mwedzi. Chidzidzo chacho chaiva nechinangwa chekuongorora kuonekwa kunorwadza kwevatori vechikamu uye kujekesa kuti kurapa kwaive kwakadini pakuderedza kushanda kwegondo rose (TKR) chirwere.
Pakupera, vatsvakurudzi vakaratidza kuti 72.6 muzana yevarwere vanobatwa ne Synvisc kudziviswa chirwere cheTKR munguva yose yekudzidza. Kunyange zvazvo pasina maitiro akaoma kana kwenguva yakareba akaonekwa, vanhu vasere vakaona maitiro ekuvhiringidza kwakatevera majekiseni. Hapana chaifungidzirwa chakakomba.
Kubva paWestern Ontario uye McMaster Universities Osteoarthritis Index ( WOMAC ), kuongororwa kunoshandiswa kuyera maonero ekurwadziwa, vanhu veSyvisc vakawana inenge 20 muzana inodonhwa nehurombo kana vachienzaniswa nevaya vari panzvimbobo.
Osteoarthritis yemabvi nhasi ndiyo inowanzosangana neArthritis muUnited States, iyo inofungidzirwa inofungidzirwa vanhu vane mamiriyoni 13.7. Kubva pane zvaakawana zvidzidzo, Synvisc inofungidzirwa senzira yakachengeteka uye inobudirira yekurapa kurwadziwa nekuremara muhuwandu hwevanhu uye, kana yakashandiswa zvakakodzera, inogona kubatsira kunonoka kuvhiyiwa kwemakore matatu kana kupfuura.
> Kwakabva:
> US Food and Drug Administration. (2008) "Yakarongwa Synvisc-Imwe Chidimbu Chekuchengetedza uye Kubudirira." Silver Spring, Maryland.