Kwete Zvose Zvinodzidziswa neBhulogi Zvinoshanda Nenzira Iyoyo Kana Uchishanda IBD
Chikoro chitsva chezvinodhaka chinoshandiswa kuporesa kuputika kunokonzerwa nekuputika kwechirwere chirwere (IBD) kunonzi biologics. Zvisinei, iyi inotambanudza yakawanda yemishonga, uye havasi vose vanoita nenzira imwe chete kana kuti vanopiwa nenzira imwe chete. Vamwe vanobvumirwa kubata chirwere chimwe chete cheBD, asi vamwe vanoshandiswa kurapa chirwere che Crohn uye chironda chekuonda.
Nemhaka yokuti zvinodhaka zvehupenyu zvinoshandura maitiro ezvirwere zvakasiyana-siyana (zvimwe chikamu chinoita kuti vashandire IBD), vanhu vanovatora vanogona kunge vachida kutora mamwe marudzi ezvirwere. Zvakakosha, saka kutora matanho ekuti uone kuti kudzivirirwa kuri munzvimbo yekudzivirira zvirwere. Vanhu vane IBD vanofanira kugamuchira zvirwere , kunyangwe vasati vatanga biologic, asi zvirwere zvakawanda zvinogona kupiwawo panguva inotora biologic.
Vanachiremba vanosarudza sei biologic agent kuti varatidze kune murwere? Kune kusiyana kwakasiyana-siyana pakati pemishonga iyi, uye zvinhu zvakawanda zvinotorwa mukufungisisa. Izvi zvinogona kusanganisira kubudirira (izvo zvinopesana nezvinoenderana nechirwere chechirwere uye sendima), mutengo, uye kushandiswa kweinishuwarenzi, pakati pezvimwe zvinhu. Vanachiremba vachadikanwa kutora zvose zvezvinhu izvi zviri pasi pekufungisisa, uye nezvimwe, pavanenge vachirumbidza murwere kune biologic mishonga.
Pasi pane kutarisa zvishomanana zvezvinhu zvezvidimbu zvemarudzi ekurapa kwebiologic.
Varwere uye vanachiremba vachada kuongorora zvinhu zvose izvi uye vamwe vasati vasarudza.
Cimzia
Cimzia (certolizumab pegol) inonzi tumor necrosis factor (TNF) blocker yakagamuchirwa muna 2008 kuzobata chirwere cha Crohn. Muna 2009 yakagamuchirwa kurapa rheumatoid arthritis, uye ye psoriatic arthritis uye ankylosing spondylitis muna 2013.
Cimzia inowanzopiwa nejoi nemushonga unopera pamba. Cimzia inopiwa majekiseni maviri, ayo anotanga kupiwa mumutambo wekutakura pamasvondo 0, 2, uye 4. Pashure pacho, majekiseni maviri anopiwa mavhiki mana. Imwe nzira yeCimzia ipfundo rinosanganiswa uye rinowirwa muhofisi yechiremba. Migumisiro inowanzoitika kakawanda nemudzvinyiriri iyi inoputika maitiro ekufema (kufanana nehutori), zvirwere zvehutachiona (kufanana nehutachiona), mahara, uye urinary zvirwere.
Nheyo dzinokosha pamusoro peCimzia:
- Cimzia inogamuchirwa kurapa chirwere cha Crohn
- Cimzia inowanzopiwa kumba nejisi
- Cimzia inopiwa pakutanga katatu mumutsara we 2 injections, mavhiki maviri kunze, inoteverwa nemajekisi maviri mavhiki mana
- Matambudziko anowanzowanzobatanidza zvirwere zvinoputika, zvirwere zvehutachiona, rashes, uye urinary zvirwere
- Cimzia ikirasi B pamuviri wemishonga
- Nhamba yakaderera yeCimzia inogona kupinda muchipfuva
- Cimzia inofanirwa kuve firiji
Entyvio
Entyvio (vedolizumab) , iyo yakagamuchirwa munaMeyi 2014, inonzi gut-homing α4β7 integrin inopikisana. Inofungidzirwa kuti inoshanda nekusunga ku α4β7 integrin, iyo inodzivirira kubatana kusingaiti kupisa. Entyvio inogamuchirwa kuti ishandiswe kune vanhu vakuru vane Crohn's disease kana chironda chemaronda.
Entyvio inogara ichipiwa nekunyanyisa, kunyangwe muhofisi yechiremba, kuchipatara, kana mune imwe nzvimbo inopindira. Mhedhi yekutakura yeCyyvio inonzi 3 infusions yakaitwa mavhiki maviri. Mushure meizvozvo, kuvhiringidzika kunopiwa pamusoro pevhiki imwe neimwe. Mimwe yemigumisiro inogona kuitika inosanganisira kuronhora, kuputika kwepamusoro kwepachirwere (utachiona, bronchitis), misoro yepamusoro, marwadzo akabatana, kushungurudza, fivha, kuneta, kukohwa, kurwadziwa shure, kuputika, kuchenesa, utachiona hutachiona, kurwadziwa kwehuro, uye marwadzo ekupedzisira .
Nheyo dzinokosha pamusoro paInyvio:
- Entyvio inogamuchirwa nehutachi inouraya uye chirwere cheCrohn
- Entyvio inopiwa nekodzero mumatatu ekutanga anotanga, uye mushure memavhiki masere
- Migumisiro yakajairika inosanganisira zvirwere (kunotonhora, furu, bronchitis, utachiona hwe sinus); kurwadziwa muzvibatanidza, shure, kumutsipa kana kumagumo; zviratidzo zvekushungurudza, fivhiri, kuneta, kukohwa, kana kuchenesa; uye kukanganisa
- Entyvio iklasi B pamuviri wemishonga
- Hazvizivikanwe ikozvino kana Entyvio inopinda muchipfuva
Humira
Humira (adalimumab) mumwewo mumiriri wemanoni uye TNF inhibitor inoshandiswa kubata vanhu vane IBD. Inogamuchirwa kune vanhu vakuru nevana vanopfuura makore matanhatu avo vane ulcerative colitis kana chirwere cheCrohn. Humira akatanga kubvumirwa muna 2002, uye akawedzerwa kuti ashandiswe muCrohn's disease muna 2007 uye ulcerative colitis muna 2012. Humira inogona kupiwa kumba kuburikidza nejisi. Varwere vanodzidziswa maitiro ekuzvipa ivo jekiseni (kana rinogona kuitwa nerubatsiro kubva kune nhengo yemhuri kana shamwari). Vamwe vanhu vane Humira vanogona kunge vane izvo zvinonzi " site injection reaction" , iyo kupfugama, kurwadziwa, kuchenesa kana kubwinya panzvimbo inoshandiswa mushonga. Izvi zvinowanzoitirwa kurapwa pamba neaini kana antihistamine mishonga (kuchinja injection nzvimbo vhiki rese inobatsirawo).
Pfungwa huru pamusoro peHumira:
- Humira inogamuchirwa kune zvose Crohn's disease uye ulcerative colitis
- Humira anopiwa kumba nekuzvidzivirira
- Humira inotanga ne 4 injections, inoteverwa nemajirisi maviri masvondo maviri gare gare, uye ipapo jira rimwe nerimwe rimwe vhiki
- Migumisiro yakajairika inosanganisira kurwadziwa kana kushungurudzika panzvimbo yejojo uye kuora musoro, kuputika, uye kusuruvara
- Humira iklasi B pamuviri wemishonga
- Vacheche vakaberekerwa vanaamai vanotambira Humira havafaniri kugamuchira zvirwere zvinorarama kwemwedzi mitanhatu
- Humira inoda kuve firiji
Remicade
Bhuku rekutanga rebiologic therapy rinobvumirwa kushandiswa kune vanhu vane IBD Remicade (infliximab) , iro rakagamuchirwa muna 1998. Remicade inonzi monoclonal antibody iyo inonzi TNF inhibitor uye inopiwa kuvarwere kuburikidza ne IV. Izvi zvinogona kuitwa muhofisi yechiremba, asi kazhinji inowanzoitika mune imwe nzvimbo yekuisa pasi, iyo inzvimbo dzakagadzirirwa kugadzirisa mishonga naV. Remicade inogona kushandiswa kurapa chirwere cheCrohn kana chironda chekurara, uye yakabvumirawo vana vaduku sevana 6, mune mamwe mamiriro ezvinhu. Remicade inofungidzirwa kushanda nevanhu vane IBD nokuti inhibits TNF, iyo inhengo inobereka kuvhiringidza mumuviri.
Nheyo dzinokosha pamusoro peRicicade:
- Remicade inopiwa neV
- Remicade inotenderwa kuCrohn's disease uye ulcerative colitis
- Matatu okutanga mazamu anopiwa (mushure mekutanga kwemuti, wechipiri mavhiki maviri gare gare, chechitatu mavhiki mana pashure pacho)
- Mushure mekutanga kwemitengo, inopiwa pamusoro pevhiki imwe neimwe (dzimwe nguva nokukurumidza kana zvichidiwa)
- Matambudziko anowanzovhiringidzika mumimba, kusuruvara, kuneta, uye kurutsa
- Remicade iklasi B pamuviri wemishonga
- Remicade haina kuonekwa kuti inopinda mumukaka wemukaka
Simponi
Simponi (golimumab) inonzi TNF inhibitor inobvumirwa kuporesa ulcerative colitis. Simponi yakagamuchirwa kutanga muna 2009 kubata rheumatoid arthritis, psoriatic arthritis, uye ankylosing spondylitis . Muna 2013 yakagamuchirwa kurapa chironda chekurara. Ankylosing spondylitis mamiriro ezvinhu anogona kuwirirana nealcerative colitis, zvinoreva kuti mishonga iyi inogona kushandiswa kurapa zvose (kana zvimwe) chirwere (s). Simponi inopiwa kumba, saka varwere vanodzidziswa nehutano hwehutano hwekuzvidzivirira pachavo (zvichida ivo pachavo kana nekubatsira). Zvimwe zvekukanganisa kwakanyanya ku Simponi ndiko kuwana zvirwere zvinokonzera zvirwere zvakadai sechando, zviratidzo zvakadai sehuropa kana chirwere chinonzi laryngitis, uye zvirwere zvehutachiona sehutachiona. Kuva nehukundu, kurwadziwa, uye kunhuwa panzvimbo yejojo, inowanzobatwa nechando uye antihistamine, chimwe chiitiko chinogona kuipa.
Nheyo dzinokosha pamusoro peCononi:
- Simponi inogamuchirwa kuti iite chirwere chekurwara
- Simponi inopiwa nejena kumba
- Simponi inotanga ne 2 injections, inotevera 1 injection 2 masvondo gare gare, uye 1 injection masvondo mana mushure mazvo
- Zvinokonzerwa nemigumisiro inowanzobatanidza kurwadziwa kana kutsamwirwa panzvimbo yejojo uye kuputika kwepamusoro kana zvirwere zvehutachiwana
- Simponi ndeye Mutauro B pamuviri wemishonga
- Hasi ikozvino kuzivikanwa kuti Simponi ichaita sei mwana anoyamwa
- Simponi inofanira kuva firiji
Stelara
Stelara (ustekinumab) munhu anonyatsokonzerwa neonoclonal immunoglobulin antibody. Yakatanga kugamuchirwa muna 2008 sechirwere chepecoriasis uye muna 2016 kuzobata chirwere cheCrohn. Stelara inoshanda kuita kuderedza chirwere cheCrohn's disease chinokonzera nekutsvaga interleukin (IL) -12 uye IL-23, iyo inofungidzirwa kuti inobatsira pakukura kwekuvhuvhuta mumatumbo. Nhamba yekutanga ye Stelara inopiwa nekodzero, mune imwe nzvimbo inopindira kana hofisi yechiremba. Mushure mokunge kuvharwa kwekutanga, Stelara inogona kutorwa kumba nejisi inopiwa mavhiki masere. Varwere vanogona kuzvipa jekiseni mushure mekunge vadzidziswa nemupi wehutano wehutano. Zvimwe zvinowanzovhiringidza zvirwere zvinowanikwa kuvanhu vane Crohn's disease vanotora Stelara vanosanganisira kushambidzika (panguva yekudzivirira kwekutanga), kurwadziwa kana kubwinya panzvimbo yejojo, kubatwa, uye zvirwere zvakadai sechando, chirwere chemuvhu, bronchitis, urinary tract utachiona, kana utachiona hwe sinus.
Pfungwa huru pamusoro peSlara:
- Stelara inobvumirwa kubata chirwere cha Crohn
- Inotakura chirwere cheStrara inopiwa nekodzero uye ipapo inopiwa nemajojo kumba
- Vanhu vanotora zvidzitiro zvechirwere vanofanira kutaura nachiremba wavo pamusoro pezvinogona kugadzirisa zvirwere uye Stelara
- Migumisiro yakajairika inosanganisira zvirwere, injection site reactions, uye kurutsa
- Stelara iklasi B pamuviri wemishonga
- Zvinofungidzirwa kuti Stelara anopinda muchipfuva
- Stelara inofanirwa kuva firiji
> Sources:
> Janssen Biotech, Inc. May 2013.
> Janssen, Inc. " Stelara (ustekinumab) Kunyora Mashoko ." Stelarainfo.com. Aug 2016.
> Amai Kumwana. "Certolizumab Pegol (Cimzia) uye Kuberekwa." MotherToBaby.org. Aug 2015.
> Takeda Pharmaceuticals, Inc. "About Entyvio." Entyvio.com. 2015.
> UCB, Inc. " Cimzia (Certolizumab Pegol) Mishonga yeMishonga ." Cimzia.com. Apr 2016.