Kutsvakurudza nezveNzira Dzakanakisisa dzeKuberekwa kweKartilage
Cartilage kuberekwa patsva kuedza kudzorerazve maronda akabatanidzwa. Nzira dzakasiyana-siyana dzave dzichishandiswa kugadzirwa kwekatekete . Kunyange zvazvo imwe yeiyi iri kushandiswa mazuva ano, vatsvakurudzi vanoramba vachitarisa munzira itsva dze regrow cartilage mukuedza kupa vanhu zororo kubva mukurwadziwa kwewasteoarthritis.
Chii Chinonzi Cartilage Inobatsira?
Matrix yekatekete inoumbwa ne collagens, proteoglycans, uye mapuroteni asina kubatana.
Kunyange zvazvo martilage ari sangano rakanyatsorongeka, inenge 85 muzana yetiketeti mvura. Izvi zvinoderera kusvika makumi manomwe kubva muzana muvanhu vakwegura. Chondrocytes ndiyo chete masero anowanikwa mutikiti uye izvi zvinogadzirwa nekuchengetedza martilage matrix.
Goroti inoshandiswa inoshandiswa sechikwata uye inoshungurudza kunyanya mukati memubatanidzwa. Izvo zvinodaro nokuti inosvika kumagumo emapfupa maviri ayo anogadzira mubatanidzwa. Cartilage kukuvadza kunogona kukonzerwa nemamiriro akawanda akabatanidza:
Masangano anokonzerwa nekartilage kukuvara anorwadza, akaoma, uye ane zvishoma zvokufamba .
Dambudziko nderokuti maronda haakwanisi kuzvirapa pachake. Nekudaro, chikafu chinonzi articular chakave chinonyanya kutaurwa nevatsvakurudzi vazhinji uye vanogadzira nyuchi dzinoedza kukwanisa kukura musana wekare uye kuisimudza panzvimbo yezvakakuvadzwa kana kuti yakasakara.
Kufambira Mberi Nokugadziriswa kweCartilage
Nzira dzakasiyana-siyana dzave dzakagadzirwa dzinoratidza kufambira mberi mukugadzika kwechikafu.
- Dhiyabhorosi kana Abrasion - A chiremba arthroscopically anobvisa tsvina yakasununguka inokonzera kubuda pamapfupa kumusoro uye kukura kwe fibrocartilage (fibrous cartilage kana zvisikwa zvitsvuku ). Mune zvimwe zviitiko, fibrocartilage inogona kunge isina simba zvakakwana kuti idzivirire zvakanyatsobatanidzwa.
- Kugadzirwa kwemakumbo - Chiremba anonyanya kukonzera nzvimbo yakakanganiswa uye anoita maitiro akawanda mumapfupa. Izvi zvakagadzirirwa kukurudzira kubuda uye kukura kwe fibrocartilage zvakare.
- Mosaicplasty kana Osteochondral Autograft Transplantation Surgery - Chiremba anovhiya anobvisa pfupa remapfupa nekatekete yakafukidzwa kubva kune imwe nzvimbo yakanyatsobatanidzwa uye inoiisa kune yakaora.
- Periosteal Flap - Chiremba anovhiya anobvisa chikamu cheperiosteum (iyo inogadzirisa mafupa akavhara mapfupa ose) kubva pachiganda uye inoiisa kune imwe nzvimbo yekushungurudzika kwekatekete .
- Autologous Chondrocyte Implantation (ACI) - Chiremba anovhiya arthroscopically anobvisa chikamu chiduku chekateti kubva pamabvi. Mhuka yacho inotumirwa kubhorosi inofanira kukurudzirwa. Kuvhiya kwechipiri kunodiwa kuitira kuti masero akakura-siyana akwanise kuiswa panzvimbo yeiyo yakakanganiswa.
- Osteochondral Allografts - Pfupa remupiro rinoshandiswa kugadzirisa maronda akaora.
- Matrix Associated Chondrocyte Implantation (MACI) - The FDA yakabvumira nzira iyi muna 2017 inoshandiswa kune vanhu pasi pemakore 55 ne "focal chondral defects" - zvipembenene zvinogona kutungamirira kuhasteoarthritis yemabvi. Izvo zvakafanana neAACI asi inoda chirwere chisina kuvhara uye chondrocytes dzinotumirwa kudzokera kune chiremba wechiremba pane chigamba chinoita sechando pamusoro penharaunda yacho.
Zvose izvi zvinobereka zvibereko zvakasanganiswa. Icho chiripo mibvunzo yakawanda iyo inotambudza kuedza kurwisa katetilage.
Zvimwe zviongorori zvekurapa zvinodiwa kuti zviwane mhinduro dzakasimba uye kukudziridza nzira dzinoderedza zviratidzo zveArthritis uye dzinoita kushandiswa kwenguva refu kwekartilage yakakuvara.
Ongororo Inopfuurira
Dambudziko rekuuya nechirongwa chiri nani chekugadziriswa kwetiketeti chiri mupfungwa dzevanotsvakurudza vakawanda. Munyika yose, tsvakurudzo itsva uye maitiro anoenderera mberi kutarisa munyaya iyi uye migumisiro yekutanga inotaridzika.
Somuenzaniso, muna 2008, bioengineers paRicon University vakawana kuti kunyanya kunetseka (kufanana nezvakawanikwa kupfuura hafu yemiraira pasi pemvura yegungwa) kunosimudzira maseroti ekurasira kukura mishonga mitsva.
Iyi nyuchi itsva inenge inenge yese yezvinhu zvekusikwa kwechikafu.
Vatsvakurudzi vanotenda kuti kubudirira kunova nechivimbiso chekurapa kweArthritis. Muongorori anotungamirira akafanotaura kuti zvichave makore mashoma vasati vazogadzirisa chirongwa chekliniki muvanhu.
Masero emashonga ari kushandiswawo kukura hutsva hutsva hwemaguno eArthritic mumagadzirirwo ari kuendeswa kuWashington University School of Medicine kubva muna 2017. Mukubatana neKytex Therapeutics, tariro yevatsvakurudzi ava ndeyokuti izvi zvichava humwe humwe humwe humwe humwe humwe huchava humwe humwe humwe humwe humwe humwe huchava humwe humwe humwe humwe humwe humwe huchava humwe humwe humwe humwe humwe huchava humwe humwe humwe humwe humwe huchava humwe humwe humwe humwe huno huchaita humwe humwe humwe humwe huchaita humwe humwe hutachiona hwekushandura .
Iyi nzira inoratidza kuvimbiswa kwevaya vari pasi pe50. Inoshandisa "3-D, biodegradable synthetic scaffold" uye inonyanya kusimuka musungo wokuputika kuti udzivise marwadzo. Kune arthritic varwere, zvinogona kunonoka, kana zvisingazobvisi, chido chekunyora mutsva.
Sources
- Axtell B. FDA OKs Kutanga muNyika Itsva yeKnee Cartilage Repair. Arthritis Foundation. 2017.
- Boyd J. Cartilage kuberekwa '20, 000 Leagues Under the Sea '. Rice University. 2008.
- Dryden J. Stem Maseku Engineered Growing Cartilage, Fight Inflammation. Washington University School of Medicine. 2016.
- > Chipatara Chekuvhiya Kunokosha. Nzira Dzokugadzirisa Kuparara Kwemakumbo Akatsigira Kuratidza Chivimbiso Mukurapa Varwere Kupfuura 40. 2016.
- > Rai V, > Dilissio > MF, Dietz NE, Agrawal DK. Mazano Akangobva Kuitika Mukugadzirisa Kwemafutiraji: Ongororo Yakarongeka yeScaffold Development uye Tissue Engineering. Nyaya yeByomedical Materials Research Chikamu A. 2017. chii: 10.1002 / jbm.a.36087.