Chirwere chinopisa simba , kana IBD, chinosanganisira ulcerative colitis uye Crohn's disease. Zvose izvi hazviregi zvirwere zvisingagumi zvemukati. Zvose izvi zvinorapwa zvinogona kuderedza chirwere uye hospital hospital.
Kuva neBD uye kurapwa nokuda kwacho kunosanganiswa nehuwandu huwandu hwekuita lymphoma, uye njodzi dzinowanzosiyana nezvimwe zvinhu kunze kwekungobatwa.
Chirwere Chirwere Chirwere
IBD inokura pamusana pokuputika mumutsipa, izvo zvinogona kukonzera kubuda ropa, fivha, kukwira kwechichena chekuyera ropa , pamwe nekurwara uye kurwadza kwepamuviri. Kuipa kwebasa muBD kazhinji kunowanikwa mune zvidzidzo zvekufungidzira zvakadai seC CT scan, kana kuti colonoscopy, somuenzaniso.
Lymphoma Risk
Vanhu vane IBD vanorapwa nedzimwe nzira dzokurapa - dzakadai sevanorwisa-TNF vashanduki uye vanoridza zvirwere zvemuviri - vari mungozi yakawanda yevamwe kanzira inosanganisira masero machena eropa lymphocyte , maererano nezvidzidzo zvakawanda. Kune kumwe kusava nechokwadi pamusoro pengozi yakawanda iripo, zvakadaro.
Lymphoma mutsara unotanga mumasero machena eropa lymphocyte, ayo ari chikamu chemuviri wemuviri wemuviri. Izvo zvikamu zviviri zvikuru zve lymphoma ndeHodgkin uye kwete Hodgkin lymphoma (NHL) . Kune mhando dzakawanda uye subtypes . Izvo zvave zvichicherechedza kuti NHL inowanikwa kune yakakwirira kudarika maonero anotarisirwa mune zvirwere zvakasiyana-siyana zvinoda kuti zvirwere zvekudzivirira zvirwere, zvakadai seBDD.
Ngozi dze lymphoma hazvifananidzi kune vose vane IBD. Ngozi dzinopesana maererano nezvinhu zvakadai sezera, zvepabonde, uye zvimwe zvinhu. Kuongorora zvipembenene uye zvinobatsira zveBD remishonga nachiremba wako chikamu chinokosha chechisarudzo chekurapa. Kakawanda, zvinosarudzwa kuti kubatsirwa kwakakura kwezvirapa izvi kunopfuura pangozi shoma inowanikwa.
IBD Treatments
Kushandisa mishonga inopesana nekuvhiringidza yeBD kukurudzira kuregererwa kuteverwa nekuchengetedzwa kwerapi nemishonga inofanirwa kugadziriswa nemasikirini ichiri nzira huru yekurapa. Thiopurines - yakadai seAzathioprin - inoshandiswa zvikuru mukurapa kwechirwere chisingaperi chinoputira chirwere chechirwere.
Mune varwere vane IBD vanorapwa ne thiopurines, kune ngozi yakawedzerwa yemamwe marudzi ekenza yeropa, asi nhamba yekenza inokura semugumisiro wehutano inofanirwa kuva duku. Mune vanhu vanoita nhengo dzemuviri, NHL inosangana nekudzivirira muviri kunonzi post-transplant lymphoproliferative disorder, uye zvimwe zvezvinozivikanwa pamusoro pengozi ye lymphoma inobva kuboka iri revarwere.
Zvimwe mapurogiramu e-lymphoma ave achionekwa nemajena ekugadzirisa zvirwere anoshandiswa muBDD. Lymphoma mushure mekutsvaga ndeimwe yavo. Lymphoma kana iine mononucleosis, kana kuti mono, inogona, uye chimiro ichi chinowedzera kukanganisa varume vaduku kudarika makore 35. Kazhinji, hepatosplenic T-cell lymphoma inogona kukura, uye inotanga kukura pashure pemakore maviri ekurapa pamwe nekubatana kwe thiopurines uye anti-tumor necrosis factor treatment, kana thiopurines chete.
- Azathioprine yaibatanidza ne 2.40 x yakawedzera ngozi yecymphoma mune imwe shanduro yakabudiswa mu "American Journal of Epidemiology."
- Kusanganiswa kwe azatioprine uye 6-mercaptopurine ine 4.92 pangozi yakakwirira yekusimudzira lymphoma pakati pevanhu vane IBD, maererano nekuongorora kwakabudiswa mu "Clinical Gastroenterology uye Hepatology."
Zvishoma zvishoma zvinozivikanwa nezve methotrexate uye lymphoma ngozi mune IBD. Nevanorwisa-TNF vashandi, chiongororo cha2009 chakawana kuti ngozi ye lymphoma ne-anti-TNF + immunomodulator yakanga yakakura kudarika immunomodulator chete.
Pasi Pasi
Iko kune mibvunzo yakawanda isina mhinduro pamusoro pesungo che lymphoma munharaunda yeBD therapy. Kana iwe uine IBD uye uchida kurapwa, zvakanakisisa kuti ukurukure chero dambudziko raunogona kuva naro pamusoro pezvipingamupinyi nechiremba wako, uyo anogona kubatsira kuisa zvinhu nenzira yakatarisa uye kubatsira kubatanidza chokwadi uye nhamba kumamiriro ako ezvinhu.
Pasina kurapa kwakakodzera, varwere vane Crohn's disease uye ulcerative colitis vanogona kuva nehutano hwakaderera hwehupenyu. Vamwe vanachiremba vanosimbisa chokwadi chekuti isu tinenge tichitarisana nenhamba shomanana yezvimwe zviitiko zve lymphoma pakati pezviuru zvevarwere, uye makore mazhinji anotitungamirira kugumisa pamusoro pengozi.
Chinhu chimwe ndechechokwadi: kushushikana kukuru uye kusagadzikana kusingaperi kunobatanidzwa nemhando dzose dzehutano hwehutano, saka kana iwe nachiremba wako masarudza kuti unoda kurapwa, hazviiti kuti iwe unakire kunetseka.
Sources:
Pasternak B, Svanstrom H, Schmiegelow K, et al. Kushandisa Azathioprin uye Dambudziko reKancer muAchirwere Chirwere Chetachiona. Am. J. Epidemiol . 2013; 177 (11): 1296-1305.
Kotlyar DS, Lewis JD, Beaugerie L, et al. Ngozi yeLymphoma Muvarwere Ane Chirwere Chirwere Chirwere Chinoitwa Neazathioprin uye 6-Mercaptopurine: Meta-analysis. Clin Gastroenterol Hepatol. 2015; 13 (5) 847-858.e4.
Bär F, Sina C, Fellermann K. Thiopurines muhutachiona hwehutachiona hunodzokororwa zvakare. World J Gastroenterol. 2013; 19 (11): 1699-1706.
Sokol H, Beaugerie L. Chirwere chechirwere chechirwere uye zvinetso zvemuviri: guruva rinotanga kugadzirisa. Gut . 2009 Oct; 58 (10): 1427-36.
Kandiel A, Fraser AG, Korelitz BI, Brensinger C, Lewis JD. Kuwedzera kwengozi ye lymphoma pakati pezvirwere zvechirwere zvirwere zvinorapwa neazathioprin uye 6-mercaptopurine. Gut. 2005; 54 (8): 1121-1125.
Askling J, Brandt L, Lapidus A, et al. Ngozi yekenza ye hematopoietic kune varwere vane chirwere chinoputika chirwere. Gut. 2005; 54 (5): 617-622.
Bhandari BM, Kroser JA, Bloomfeld RS, Lynch SP. Chirwere Chirwere Chirwere. American College of Gastroenterology. 2013.
Siegel CA. Ngozi yeLymphoma muAchiremera cheMuviri Wezvirwere. Gastroenterol Hepatol. 2009; 5 (11): 784-790.