Kusvikira munguva pfupi ichangopfuura, vanachiremba vakawanda vakapa cholesterol-kudya-CHD hypothesis. Chokutanga, kukwidziridzwa kwekorotera muropa kana hypercholesterolemia kunokonzera coronary heart disease (CHD). Chechipiri, kudya kwakagadzirwa nemafuta emhuka uye cholesterol inowedzera cholesterol muropa. Chechitatu, kuderedza cholesterol muropa kunoderedza dambudziko rekodonary heart disease.
Pakukosha kwebasa, cholesterol-kudya-CHD hypothesis inoratidzika kuva inonzwisisika. Mushure mezvose, "isu tiri izvo zvatinodya," uye kana tikadya zvokudya zvakapfuma mucholesterol uye yakazara (mhuka) mafuta, ipapo ropa redu rekutsvalaira rinogona kukwira. Uyezve, nokuti mabheti-mavhari evhavha uye anoita kuti chirwere cheCD uye chirwere-zvive chikamu chakagadzirwa necholesterol, kuwedzera kwehushuterolin muropa rechipiri kune kudya kunowedzera dambudziko reKDD nekurohwa. Uye, kana iwe uchingoderedza cholesterol muropa rako uchishandisa mishonga, iwe unoderedza ngozi yako yeCDD nekurova, kurudyi? Zvakanaka, nekuremekedza izvozvi zvose zvingafungidzirwa, hazvigoneki.
Kunyanya ichangopfuura, pane kuchinja kwegungwa mumitemo inotungamirira kutungamirirwa kweCDD. Hatina chokwadi kana kudya kunowanikwa muhushutera uye mafuta akazara zvinokonzera zvakananga kuwedzera mazinga echolesterol muropa. Uyezve, hatinzwisisi kana kuderedza ropa rekutsvaga kwehutachiona kune avo vari pangozi yezvirwere zvemoyo kunobatsira kudzivisa kurwadziwa, angina isina kugadzikana, kurwisa kwemwoyo uye nezvimwe.
Zvose zvatinoziva ndezvokuti mararamiro ehupenyu (somuenzaniso, kurasikirwa, kuraira muviri uye kusvuta kusvuta) pamwe nemasitini, kana zvinodhaka zvakadai seZocor uye Crestor, izvo zvinogadzirisa zvirwere uye zvinowedzera kuderedzwa kwepoprotein lipoprotein cholesterol (LDL-C) kana kuti "zvakaipa" cholesterol, zvichida kubatsira kubvisa rufu uye zvimwe zviitiko zvinotambudza mwoyo,
Evolocumab ndeyeji itsva yechirwere. Mumakiriniki ekuedzwa kwakave zvichiratidzwa nekukurumidzira kuderedza maLDL-C mumakwikwi akasiyana-siyana muvanhu vanobatanidzwa-zvikurukuru kune avo vane genetic disorder inonzi mhuri ye hypercholesterolemia inokonzera cyclopean (chaizvoizvo, yakakosha) mazinga echolesterol muropa. Iye zvino kana evolocumab ichapa chero rubatsiro kuvanhu vakawanda vari panjodzi yekufa uye zviitiko zvinotambudza zvinokonzerwa nechirwere chemoyo chinoramba chiripo, uye zvichida zvinoenderana nemigumisiro yenguva refu kana inotarisira zvidzidzo inotarisa vatori vechikamu mumakore evolocumab (Repatha ) therapy. Mune mamwe mazwi, nguva chete ichataura kana evolocumab inoshanda.
Chii Chinonzi Evolocumab?
Evolocumab inonyatsoitwa munhu monoclonal antibody inosunga uye inodzivisa purotini PCSK9. Iyi protein inopindira ne-receptor inotora LDL-C yekusvibiswa nechiropa uye inopindirawo kukwanisa kwemugamuchira uyu kugadzirisa zvakare. (Zvinofadza, kutsvakurudza kunoratidza kuti mitemo inogona kunyanya kuwirirana PCSK9, zvisinei, kana yakashandiswa pamwe, mitemo uye evolocumab haisi kunyatsogadzirisa kana kukwanisa.)
Parizvino, Amgen, evolocumab's maker, ari kuita mamiriyoni makuru emakiriniki miedzo muvanhu vakasiyana-siyana varwere munyika yose.
Migumisiro yematambudziko aya ari kuvimbisa nekuremekedza kukwanisa kwe evolocumab kuderedza mazinga eLDL-C. Somuenzaniso, mune imwe chirongwa cheGe 3, vatori vechikamu vane chirwere chakaipa kwazvo chemhuri (hypercholesterolemia) (homozygous family hypercholesterolemia) avo vaiva pamagadzirirwo emitemo (vamwe vaivewo mune imwe mishonga yeCholesterol inonzi Zetia) vakawana kuderera kwe 31% muzana reLDL-C pa12 vhiki dzinoenzaniswa nevarume vasina kugamuchira mishonga. (Vakapindawo vakawanawo 23 kubva muzana kuderera kweapolipoprotein B.) Zvakakosha, evolocumab yakashanda nekukurumidza kupfuura mamwe mimwe mishonga mitsva inouya pasi pipeline: lomitapide uye mipomersen.
Kuti uite basa, maererano nemigumisiro yakaipisisa, evolocumab zviri nani kubvumira kupfuura komitapide uye mipomersen.
Mune chimwe chikamu cheChitatu chechitatu, vatori vechikamu vakanga vasingafariri mitemo miviri uye vakabatwa ne evolocumab neZetia chete vakaona 53 kusvika 56 muzana kubva muzana yeLDL-C kana vachienzaniswa ne 37 kusvika 39 muzana muzana yevatori vechikamu vanowana Zetia chete. Uyezve, evolocumab yakaita zviitiko zvishomanana zvakashata kupfuura Zetia.
Pakupedzisira, mune zvidzidzo zveChikamu chepiri, mune vagovani vane hypercholesterolemia uye vatove vari pakati nepakati kusvika kune yakakwirira-stin therapy, evolocumab yakaderedzwa maLDL-C nema 66 kusvika 75 muzana apo inoshandiswa kaviri pamwedzi.
Rinogona Kubatsira Vaparu Zvechokwadi Here?
Panguva ino, juri rinenge risiri kunze kwekuti kana evolocumab ichakwanisa kupa chero hupi hupi hwehutano kuvanhu vari pangozi yekurohwa nekurwadziwa kwemoyo. Kungoderedza cholesterol maitiro zvichida zvinoreva zvishomanana kuvanhu vakawanda, pfungwa yakatorwa kumusha nemitemo itsva yeAAC / AHA iyo yakabvisa zvachose "chinangwa" maitiro e serum cholesterol. Uyezve, izvi zvinongororwa zvinoratidza kuti maitiro, iyo chete mishonga inonyatsoratidza chero kubatsirwa mukuderedza kuora mwoyo kwepfungwa uye kufa, inofanira kurongerwa kune vanhu vane hutano hwepfungwa (chirwere kana chirwere chemoyo), vanhu vane LDL-C dzinopfuura 190 ( yakakwirira kwazvo ye "cholesterol" yakaipa kwazvo, vanhu vane makore makumi mana kusvika ku75 vane chirwere chechirwere cheshuga, uye vanhu vane makore makumi mana kusvika kune makumi manomwe nemakore makumi manomwe nemashanu vari mukana wehutano hwehutano mumakore gumi anotevera.
Kana panguva yakareba yekurapa kwechirwere ichi inotevedzana nemakore akawanda, evolocumab inoratidza zvakajeka pakugadzirisa migumisiro yehutano hwepfungwa sezvakaita chirwere chepfungwa uye kushaya mwoyo, zvino tiri kutarisa kubudirira kwemishonga inogona kuenzaniswa nemitemo. Isuwo tiri kutarisana nekusimbiswa kwecholesterol-kudya-CHD hypothesis iyo yakave yakaratidza kuti haifaniri kunge yakatarwa nemakore ekuongorora zvesayenzi. Pakupedzisira, kukwanisa kwe evolocumab kuderedza mitemo yeLDL-C kune vanhu vakasiyana-siyana vanopinda muzvikamu kunounza mupfungwa ye drug blockter Zetia, iyo yakaratidza kuti haina kubudirira (kana kunyange zvishoma zvinokuvadza) mukudzivirira kuiswa kwepakiti mukudzidzira. Mune mamwe mazwi, Zetia yakanga yakaoma zvikuru uye saka inogona kuva evolocumab
> Sources
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