Zvinowanzoitika, Zvisingaiti, Zvitsva-Kubva, uye Xenoestrogens
Estrogen inokosha hurimoni inodzora kuchinja mumuviri wemukadzi. Zvimwe zvekuchinja izvi zvakanyanya kunaka, zvakadai sekuchengeta mafupa ako akasimba asi zvinogonawo kutungamirira kukura kwekenza yemazamu. Chii chaunofanira kuziva pamusoro pemhando dzezvisikwa zvestrogen zvinokonzerwa mukati memuviri wemukadzi, maitiro eestrogen, plantro-based estrogen, uye xenoestrogens?
Chii chinonzi Estrogens?
Estrogen haisi ikemikari imwe chete asi pane boka rehomoni inokonzera kukura kwomukadzi uye kukwanisa kuva nevana.
Estrogen inobatsirawo kuchengetedza kuenda kwako kumwedzi , inodzivirira mapfupa kubva pakuonda, uye inochengeta cholesterol zvakadzika pasi kudzivirira mwoyo wako. Kunyange zvazvo isrogen inowanzodiwa uye yakakodzera hormone, estrogen dzimwe nguva inogona kushandura hutano hwemazamu mumarariya.
Haasi ose estrogen anobudiswa mumuviri wemukadzi, zvisinei, uye iwe unogona kunge uchiziva maitiro eestrogens mukuzvarwa-kumira mapiritsi uye hormone replacement therapy. Nhamba yacho hairegi ipapo. Kune phytoestrogens iyo inongoshandurirwa mu "plant estrogen" pamwe chete ne xenoestrogens, eestrogen dzakasimba dzinogona kurarama mune zvose kubva pamaplastiki kusvika kuzvinosvibisa ..
Natural Estrogens muChiratidzo cheMukadzi
Mhando dzeestrogen mumuviri wemukadzi dzakasiyana-siyana zvichienderana kana ari premenopausal kana postmenopausal. Kunewo maitiro akasiyana eesrogen mukati memuviri wako unoitwa nenzira dzakasiyana.
Pre-Menopausal Estrogens
- Estrone (E1): Estrone ndiye yakagadzirwa mumayamu mavari asati asvika kumwedzi. Mushure mokunge apera, isrone yakachengetwa mumuviri wemafuta uye masero masero. Vakadzi vane mafuta akawanda omuviri vacharamba vachitonhora kupisa panguva yekuenda kumwedzi, kunyange zvazvo muviri wavo uri kuchengetedzazve Estrone kupfuura vakadzi vane slimmer. Estrone inogadzirwa inowira pasi panguva yekuzvitakura, iyo inoderedza mararamiro ako oupenyu kune estrogen. (Ichi chikonzero nei kubata pamuviri kune chidziviriro pakurwisana kwekenza yepamu).
- Estradiol (E2): Kufanana nesrone, estradiol inogadzirwa mumayamu. Munguva yepamuviri, pane zvishoma zvekugadzira isradiol zvakare.
- Estriol (E3): Estriol inogadzirwa ne placenta panguva yekuzvitakura. Iri rudzi rweesrogen rinobudiswa mune zvakawanda kwazvo, kupfuura esrone kana estradiol, panguva yekuzvitakura. Estriol ikarongwa chiratidzo chehutano hwemwana wako
Menopausal Estrogens
Sezvaunoswedera pedyo nekuguma kwepamuviri , mazai ako achapera (atrophy) uye kugadzirwa kweesrogen uye progesterone kuchachinja panguva iyoyo. Ndiyo maodzanyemba emahomoni aya anokonzera kupisa kunopisa , nguva dzisina kufanira, usiku hunyoro, mafungiro emhepo uye zvimwe zviratidzo. Vanachiremba vanogona kurapa zviratidzo izvi nehommone replacement therapy (HRT) kwenguva pfupi, asi kushandiswa kwenguva refu kwakabatanidzwa nehuwandu hwekenza yepabonde.
Mushure mekuguma kwemazuva, androgens (mahomoni evanhu) akabudiswa ne-adrenal glands anoshandiswa mumasumbu mune esrogen. Izvozvi zvinoshandiswa kune vakadzi vane postmenopausal estrogen receptor-positive chenza chepamu. Iyo enzyme (protein) ine mutoro wekushandura uyerogens kune estrogen inonzi aromatase. Kenza yemukaka yemishonga inonzi aromatase inhibitors (yakadai seAromasin, Arimidex, uye Femara) inopindira nezviito zve enzyme kuitira kuti estrogen isisakwanisa kubudiswa.
Estrogens Inobudiswa Kunze Kwemuviri
Pane mitatu mikuru yeestrogen yakabudiswa kunze kwemuviri wako zvakare. Zvimwe zvakasikwa nezvirimwa, zvimwe zviri mumamiriro ezvinhu, uye rudzi rwechitatu runosanganisira izvo zvakagadziridzwa mubasa.
Phytoestrogens
Phytoestrogens masimiro eestrogen anowanikwa mumiti uye mabhodhoro. Izvi zvinonzi phytoestrogens zvinogona kuva nesrogen-semigumisiro mumuviri wako kana iwe uchivarova. Izvozvo zvinogadzirwa nemiti isrogenji zvakanyanya kuderera kupfuura estrogen inokonzerwa nemazivi enyu asi inogona kuva nehutachiona hunobudirira.
Izvo zvinopesana kutaura nezve phytoestrogens. Kuziva isrogen inobatanidza nehuwandu hwehutano hwekenza yemazamu, zvinoreva here kuti haufaniri kudya mbeu? Inobatsira kunzwisisa kuti isrogens yakasimwa yakasikwa inoshanda nenzira yakasiyana pane mahomoni edu ovari. Mumitumbi yedu, phytoestrogens inogona kuva nesrogen-seye kana kuti anti-estrogen madhara zvichienderana nehutundu chaihwo.
Zvinogona kunge zviri nyore kutsanangura izvi nekucherechedza kuti sei kenza yemukaka tamoxifen inoshanda. Apo vakadzi avo vane premenopausal estrogen receptor-positive chenza chepamu, ichi chinodhaka chinogona kuderedza ngozi yekudzokorora. Tamoxifen inosunga kune estergen receptors asi ine estrogen-yakafanana nemamwe maitiro uye anti-estrogen migumisiro kune vamwe. Nemazamu masero (uye masero emukenza webonde), tamoxifen inosunga paestrogen yestergen kuitira kuti estrogen isasagona kusunga. Chiito ichi chinodzivirira isrogen kubva kusunga uye kukurudzira kukura kwemarara. Mune mamwe mishonga, zvisinei, inogona kuva nesrogen-yakafanana nemigumisiro. Nokuda kwepro-estrogen yayo inobata pamapfupa, inogona chaizvo kushanda kusimbisa mapfupa akafanana nenzira iyo inonzi ecenrogen inowanzoita.
Mimwe miriwo ine phytoestrogens inosanganisira soya, red clover, nyemba, zvipembenene zvekudya, uye mafirkseeds. Kune zvizhinji zve "zvinokonzerwa" zvezvokudya zvinowedzera zvinosanganisira phytoestrogens zvinoshandiswa kurapa zvirwere zvemenoopausal zviratidzo. Zvakakosha kucherechedza kuti mamwe emishonga iyi yemishonga haafaniri kushandiswa nevakadzi vane kenza yemazamu kana kuti kune ngozi yakawanda yekuvandudza chirwere chacho.
Xenoestrogens
Xenoestrogens yakabva pamakemikari aripo munzvimbo yedu, mazhinji ayo ari petrochemicals. Xenoestrogens yakanyanya kukunda kupfuura isrogen muviri wako unoita, uye kunyanya kuratidzwa kwezvinhu izvi zvinokonzerwa nemasikirwo eestrogen-akaita seanove nemigumisiro yakaipa pahutano hwako. Xenoestrogens ari mune rimwe boka remakemikari anonzi se-endocrine kuvhiringidza maitiro ayo ari kukonzera kufarira uye kunetseka mukukanganisa kwavanoita muviri wemunhu pakukura nekukura. Bisphenol-A inowanikwa mune mamwe mapurasitiki ndeimwe muenzaniso.
Kunyange zvazvo kutsvakurudza kuri kure nekukwana, kune uchapupu hwokuti zvimwe zvezvinokonzerwa izvi zvinogona kukanganisa kukurudzika kwepabonde, kubereka, uye kunogona kuva chiitiko chekutengesa kenza yepabonde. Tinoshandisa michina ine xenoestrogens zuva nezuva. Inogona kuwanika mune mamwe mapurasitiki, magetsi, mishonga, zvokudya, seseti, uye pesticides. Nzvimbo yedu (mvura, mhepo, ivhu nemiti) iri kusvibiswa ne xenoestrogens kubva pakugadzira mhepo uye kurasa kwezvinhu zvine xenoestrogens.
Synthetic Estrogens
Synthetic estrogens inobudiswa nemakambani emishonga uye inosanganisira iyo yakagadzirwa nesrogen inozivikanwa seEthinyl estradiol . Synthetic estrogens, kufanana ne-xenoestrogens, kazhinji inowedzera simba kupfuura maestrorogeni chaiwo. Inogona kuwanika mumishonga yakafanana yakadai sekuberekwa kwepiritsi uye hormone replacement therapy.
Musati gore ra2002, hormone replacement therapy (HRT) yakagadzirirwa zvikonzero zvakasiyana siyana uye kazhinji yaionekwa sepiritsi inoshamisa inogona kuderedza kusakara. Iyo inoshanda chaizvo mukuderedza zvirwere zvemenaopausal zvakadai sekupisa kunopisa uye kuomeswa kwemadzimai, uye zvinoitawo kunobatsira kubatsira mafungiro evanhu anowanzosvika panguva yekuguma. Mukuwedzera kune kutarisa kwevanhu vane zviratidzo zvemenoopausal, yakave ichipemberera nekuda kwekugona kuderedza mapfupa emapfupa, pamwe nekufunga mafungiro maererano nehutano hwemwoyo neAlzheimer's.
Chidzidzo chevakadzi chinonzi Health's Initiative chakabudiswa muna 2002 chakavhundutsa vakadzi uye vanachiremba avo zvakafanana. Iyo yekare chishamiso chemishonga, apo ichichiri chekubatsira kwemainiopausal zviratidzo chakanga chisina kubatsira pakuderedza kushungurudzika kwemwoyo uye kurohwa. Uye zvinonyanya kukosha pane zvose ndeyokuti HRT chaizvoizvo yakawedzera njodzi yekenza yemazamu. Ichisimbiso chekuwana kutsva, mitezo ematambudziko matsva emukenza webonde akatanga kumira sezvo vazhinji vevakadzi vakamira kutora HRT.
Estrogens uye Chechi yeBeer Risk
Estradiol inowedzera mukana wekudzivirira kenza yepazamu mumadzimai evanhu vanopinda mumasopaopausal.
Mishonga yemakemikari yemishonga (kuberekwa kwepiritsi) inosanganisira estrogen, uye kune dzimwe nyevero mukushandisa madhiragi aya. Kune vakadzi vari pangozi yekenza yemazamu, kuberekwa kwekuberekwa kunogona kuisa njodzi. Kuberekwa kwepiritsi kunowanikwa (asi kazhinji) kunobatanidza nemashiro uye ropa maziso (deep vein thrombosis).
Masero esrogen ari pasi anowanikwa nehutano huri pasi hwekuita kenza yemvere. Kuva nemwana wekutanga usati wava nemakore makumi matatu uye kuva nevana vakawanda kunobatanidzwa nehuwandu hwehutachiona (nekuda kwekuderedzwa kweiestrogeni panguva yekuzvitakura). Nyaya, kunyange zvakadaro, kuve nepamuviri kunobatanidza nehuwandu hwekuita kenza yemavhesi pasi pemutsara, asi mungozi yakakwana mushure mokuberekwa ndeyechokwadi kupfuura vakadzi vasina kuberekwa.
Kunyange zvazvo vanachiremba vasingashandisi ropa reesrogen maitiro ekuwana mukana wako wekenza yepazamu, zvakakosha kubvuma basa remahomoni aya mukukonzera kenza. Kuti urambe uine utano hwakanaka hweweserogen, vanachiremba vanokurudzira kuti utore matanho ekuderedza dambudziko rako rekuita kenza yepabonde:
- Ramba uine utano hwakanaka
- Deredza uwandu hwewaini yako
- Dzidzira nguva dzose
- Dzivisa kupora-menopausal hormone therapy kana chiremba wako achifunga kuti uri pangozi
- Chengetedza meso ako nenzeve kuti udzidze zvakawanda nezve xenoestrogens. Mazhinji emakemikari aya akaoma kudzivisa, asi kuchenjerera kusvikira taziva zvakawanda zvingangodaro kuchenjera. Pane hutsvakurudzo hwakawanda hunoenderera mberi uye isu tichanzwa kunge tichinzwa zvakare mumakore anotevera. Zvidzidzo zvakadai semunhu anotarisa Bisphenol-A kukanganisa kamu kanzvadzi yepabonde yemararamiro inoratidza kuti basa re xenoestrogens mukukura kwekenza yemazamu rinoda kunyatsongororwa kunogona kungove chidimbu chechando.
- Kana uri kufunga nezvekutora mishonga yekugadzira mishonga inotora phytoestrogens, taura nemudzidzisi wehutano uyo akadzidza izvi zvinowedzera. Kune vamwe vanachiremba vakatora chido chakasimba mukubatanidza nzira idzi dzisina kufanana nemishonga inowanzogonesa iyo inogona kukubatsira kunzwisisa zvinogona kuisa njodzi uye kubatsirwa.
Sources:
> Fucic, A., Gamulin, M, Ferencic, Z. et al. Maitiro ezvakatipoteredza kune Xenoestrogens uye Estrogen Related Cancers: Kubereka Zviratidzo, Breast, Makuhwa, Chirwere, Pancreas, uye Brain. Environmental Health . 2012. 11Suppl 2): S8.
> Nagaprashantha, L., Adhikari, R., Singhal, J. et al. Shanduro dzekushandura Dzakakurumbira-Maitiro Akasikwa Phytochemicals uye Targeted Agent Kusanganiswa muBritain Cancer. International Journal of Cancer . 2017 Oct 4. (Epub mberi kwekudhinda).
Fuhrman BJ, Schairer C, Gail MH, et al. "Estrogen metabolism uye mungozi yekenza yebonde mumadzimai emasopaopausal". National Cancer Institute. 2012, 326-339.
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