Compazine, Thorazine, uye Reglan for Migraine Kurwisa neNausea
Vanopfuura hafu yevanhu vanokura kushungurudzika uye kurutsira panguva yekurwiswa kwemigraine. Sezvo chirwere chinonzi neurotransmitter dopamine chave chichibatanidzwa sechirevererano chikuru chekushungurudzika kwepfungwa munguva yemagraine, mishonga inodzivirira dopamine receptors (inonzi dopamine vanopikisa) inoshanda mukuderedza kushungurudza uye kurutsa. Zvinofadza kuti antiemetic idzi dzinoderedzawo kurwadziwa kwemigraine, uye saka dzinowanzoshandiswa sechirwere chete mukurapa zvakakomba migraines.
Compazine in Migraine Treatment
Antipsychotics yakadai seCompazine (prochlorperazine) inowanzoshandiswa kurapa zvakanyanya migraines uye inosanganiswa neusea.
Mukuwedzera pakurapa kusuruvara kwakanyanya uye kurutsira, Compazine inoshandiswawo mukurapa schizophrenia uye kurapwa kwenguva pfupi kwevanhu vese vasingagoneki nehana. Compazine inowanikwa semapiritsi, zvakasimudzirwa-yakabudiswa capsules, iyo inonzwika mumvura, fomu yemidziyo, inoshandiswa nemidziyo - iyo inowanikwa mukati mekunge (kuburikidza nemuviri) kana kuti inomususcularly (in muscle). Pamusana pekutambudzika kwemishonga yemuromo nemagraine-kufambidzana kunoshungurudza uye kurutsira, Compazine inopiwa kana intravenously kana intramuscularly nokuda kwekuregererwa kwechiratidzo - kazhinji mune imwe nzvimbo yekukurumidzira, nzvimbo yekukurumidza yekuchengetedza, kana kliniki.
Zvimwe zvinokonzerwa nemitemo yeCompazine dzinosanganisira kugona, chirwere, chimiro, kusviba kweganda, kuderedza ropa, uye amororrhea. Extrapyramidal migumisiro inogonawo kuitika semasaisai emasumbu, kusagadzikana, parkinsonism , kana tardive dyskinesia.
Chinhu chisingawanzoviki asi chinogona kutyisidzira upenyu kuCompazine (uye mamwe antipsychotics) ndiNeuroleptic Malignant syndrome, iyo inokonzera zviratidzo zvakasiyana-siyana zvinosanganisira fevha, kusagadzikana kwemisimba, nekuvhiringidzika.
Thorazine in Migraine Treatment
Thorazine (chlorpromazine) imwe inguva antipsychotic dzimwe nguva inoshandiswa kuporesa migraines yakaoma uye inosanganiswa neusea uye kurutsa.
Kufanana neCompazine, inowanzopiwa mukati-kati kana kusinganzwisisiki kune migraine uye kuregererwa kwemhepo. Mukutaura kwezvibatsiro zvaro, maererano nekudzidza kwegore ra2013 mu Journal of Emergency Medicine , Thorazine yakagadzirisa kurwadziwa kwepfungwa, kushungurudzika, uye kunzwisisika kune chiedza uye inzwi kune vanhu vane migraine kana vachienzanisa nevanhu vanotora placebo (saline infusion). Asi muchidzidzo ichi, vanhu vakawanda vakaona kugona uye chiruma kana vakamira pavanotora Thorazine, kana vachienzanisa nevanhu vakagamuchira placebo.
Reglan in Migraine Treatment
Reglan (metoclopramide) inodzivirirawo dopamine receptors. Asi zvakasiyana nedzimwe mishonga inopesana, inoshandiswa kuwedzera gastric motility kune vanhu vane matambudziko ekudzora dumbu ravo, savanhu vane chirwere cheshuga. Kufanana neCompazine, Reglan inowanzoshandiswa kurapa marwadzo ane chokuita ne-migraine uye kurutsira, kunyanya muimba yekukurumidza kana kuchengetedzwa kwekukurumidza, uye inoshanda. Zvechokwadi, imwe yekubvunzurudzwa kweCorkrane yegore ra2013 yakawana kuti kusanganiswa kweRéglan uye aspirin kwakagadzirisa migraine-inobatanidza kushungurudza uye kurutsira nezvishoma zvisingabatsiri kana zvichienzaniswa ne triptan Imitrex (sumatriptan).
Kunyange zvazvo Reglan anowanzova nemigumisiro shomanana pane dzimwe antiemetics, zvinowanzobatanidzwa:
- kusagadzikana
- kuneta
- chizoro
- headache
- kuvhiringidzika
- zvinetso kurara
Kufanana neCompazine kunyange zvakadaro, miitiro yakakomba yakawanda seyedzidzo ye extrapyramidal uye Neuroleptic Malignant Syndrome inogona kuitika (inonyanya kuwanikwa). Uyewo, Reglan inogona kuwedzera mungozi wemunhu wekuora mwoyo uye kuzviuraya.
Pasi Pasi
Nokuda kwemigraine-inosanganiswa nekushusha uye kurutsira, mishonga inodzivirira dopamine receptors muuropi (dopamine antagonists) inowanzoshandiswa, kunyanya Compazine, Thorazine, kana Reglan. Kunyange zvazvo yakanyatsobudirira, mishonga iyi inotakura mungozi. Iva nechokwadi chekuudza chiremba achikubata iwe nezvose zvinetso zveutano nemishonga, kusanganisira mavitamini, zvekuwedzera, uye kupfuura-the-counterrapies.
Sources:
Bigal ME, Bordini CA & Speciali JG. Intravenous chlorpromazine munharaunda yekukurumidzira kushandiswa kwemigraines: chirongwa chinongororwa chisingatarisirwi. J Emerg Med . 2002 Aug; 23 (2): 141-8.
Flake ZA, Linn BS & Hornecker JR. Kusarudzwa kushandiswa kwe antiemetics munzvimbo yekugadzirira. Ndiye Chiremba weNzara 2015 Mar 1; 91 (5): 29306.
Láinez M JA, García-Casado A & Gascón. Kunyatsogadziriswa kwekushungurudza kwakanyanya uye kurutsira mumigraine: kuvandudza zvirwere zvevarwere. Chiremba Relat Mugumisiro Meas . 2013; 4: 61-73.
US Food and Drug Administration. Mishonga Gwaro: Compazine. Yakasvika muna February 4, 2016.
US Food and Drug Administration. Mishonga Gwaro: Reglan (metoclopramide injection). Yakasvika munaFebruary 5th 2016.
ZVINOKUDZIDZA: Mashoko ari panzvimbo ino ndeongangwa dzekudzidzisa chete. Icho hachifaniri kushandiswa sechinzvimbo chekuchengetedza iwe pachako nechiremba ane chiremba. Ndapota ona chiremba wako kuti aongororwe uye kurapwa chero kupi zvako pamusoro pezviratidzo kana chirwere chechiremba .