Kuneta ndechimwe chezviratidzo zvinowanzoonekwa zve Multiple Sclerosis (MS) , uye zvinogona kuva zvakanyanya kukanganisa uye zvinoremedza-dzimwe nguva kunyange zvakanyanya kudarika zviratidzo zveMMS, sematambudziko asina simba kana matambudziko.
Mukuwedzera pane kusaremara, kuneta kweSM-yakanyanya chiratidzo chinonyangadza kuporesa. Kunyange zvazvo Provigil (modafinil) uye Symmetrel (amantadine) inowanzonyatsotsanangurwa kuti ineta ye MS, hapana humwe uchapupu hwezvesayenzi hwokusimudzira kushandiswa kwavo.
Uyewo, mishonga iyi ine zvimwe zvisingabatsiri. Somuenzaniso, Provigil (modafinil) inogona kukonzera kusuruvara, izvo zvinogona kukuvadza kuneta kwomunhu. Fungidzira uchikwira usiku humwe-izvi zvinongotanga kupfuurira, kwete kungobatsira, kupera kwako.
Saka vazhinji vadzidzisi veSMS (uye vanhu vanogara neMS) vari kutsvaga kutsvaga mhinduro yekurwisana nekuneta kwe MS. Nepo maitiro emararamiro akaita semishonga ekurovedza ave akaratidza chivimbiso, vazhinji vari kutsvaga "kuneta-kurwisa piritsi."
Coenzyme Q10
Coenzyme Q10 , inozivikanwawo seCoQ10, inonzi antioxidant inowanikwa mune imwe sero yese mumuviri wako. Sezvinorwisa antioxidant, iyo inotambisa rusununguko rusununguko, runogona kukuvadza masero mumuviri wako. Nokurwisa rusununguko rwehudical, coenzyme Q10 inofungidzirwa kuchengetedza masero ane utano, kuvandudza kushanda kwavo uye simba remasabolism.
Coenzyme Q10 inofanirwawo kuti ine anti-inflammatory properties. Izvi zvinoreva kuti zvinogona kugadzirisa zvirwere zvemuviri zvevanhu, izvo zvatinoziva zvinopfurikidza kune munhu ane MS.
Ichokwadi, kutsvakurudza kwakaratidza kuti kuwedzera kwekuwedzera ne coenzyme Q10 kunokonzera dzimwe zviratidzo zvekuvhiringidza, semukirini necrosis factor (TNF) , muropa remvura.
Saka, chimwe chekuwedzera se coenzyme Q10 chinoderedza yako kana kuti yakaneta yako yeWS-yakaneta? Izvo zvingave zvakakodzera kuedza, maererano nekudzidza kumwe. Izvo zvataurwa, iva nechokwadi chekukurukurirana chero kupi zvako kutsva kana mishonga nachiremba wako kutanga kuti uve nechokwadi kuti yakachengeteka uye yakarurama kwauri.
Kurapa MS Kuneta neCoenzyme Q10
Mukudzidza muna 2016 muNutritional Neuroscience, 45 vatori vechikamu vane multiple sclerosis vakagadziriswa kugamuchira 500mg ye coenzyme Q10 kana piritsi ye placebo zuva revhiki gumi nembiri. Chidzidzo chacho chaipofumadzwa zvakapetwa, zvisingatauri vatori vechikamu kana vaparidzi vaiziva avo vakagamuchira coenzyme Q10 kune avo vakagamuchira piritsi ye placebo.
Pakutanga kwechidzidzo, chiyero chinowanzoshandiswa kuenzanisa kuneta muSMS (chinonzi Fatigue Severity Scale) chaitarisirwa kune vose vatori vechikamu. Yakazoshandiswa zvakare pamagumo ekudzidza (pamasvondo gumi nemaviri).
Iyo Fatigue Severity Scale (FSS) ine zvinyorwa zvipfumbamwe zvinowanikwa pane imwe nhanho-yechinomwe, nechirevo chimwe chete "chinopesana zvachose" uye zvinomwe zvinoreva "zvakasimba kubvumirana." Izvo zvikwereti zviyero zviyero zvezvipfumbamwe zvipfumbamwe, uye zvikwata zvakakwirira zvichiratidza kuneta kwakanyanya.
Chirevo chemuenzaniso kubva pachiyero "kuneta kunopesana nebasa rangu, mhuri, kana hupenyu hwemagariro evanhu." Kana iwe wakabvumirana zvakasimba neshoko iri, iwe unokora 7 (chikwata chepamusoro).
Migumisiro yenyaya yacho yakawana kuti vatori vechikoro vakatora coenzyme Q10 vaiva nekuderera kukuru muhuwandu hwavo hweFSS-izvi zvinoreva kuderera kuderera-zvichienzaniswa nevatori vechikamu vakatora piritsi ye placebo.
Kurapa Dhiyabhorosi Dhiyabhorosi muMS neCoenzyme Q10
Muchidzidzo chakafanana, vose vevatori vechikamu vakaongororwawo nezvezviratidzo zvekuora mwoyo vachishandisa Beck Depression Inventory (BDI).
BDI ine mibvunzo makumi maviri nemumwe mibvunzo yakasarudzwa yakawanda inowanikwa pane imwe yero kubva ku zero kusvika kune mitatu, uye mitatu inomirira zviratidzo zvakanyanya. Mienzaniso yezvirwere zvekuora mwoyo zvinowanikwa munyaya iyi zvinosanganisira:
- manzwiro okusuruvara, kusava netariro, kuora mwoyo, kushaya mhosva, uye / kana kusagadzikana
- zviratidzo zvomuviri sekurasikirwa nekurema, kuneta, kurasikirwa kwechido mune zvepabonde, uye kurasikirwa nechido
- kuzviuraya
Pakupera kwekudzidza, vatori vechikamu vakatora coenzyme Q10 vakave nekuvandudza kukuru muzvirwere zvavo zvekuora mwoyo, zvichienzaniswa nevatori vechikamu vakatora piritsi ye placebo.
Zvinoreva Zvidzidzo Zvidzidzo
Zvigumisiro zvinoratidza kuti coenzyme Q10 inobatsira pakugadzirisa zvose kuneta uye zviratidzo zvinodzvinyirira muvatori vechikamu neMS. Ichi chirevo chinonakidza, kunyanya sezvo coenzyme Q10 inowanikwa pane-the-counter.
Iyo inewo yakadzika yechiratidziro yehuwandu hwehuwandu, ine huwandu hunoenderana nemigumisiro inosanganisira:
- dumbu rinogumbura
- nausea
- chirwere
- mapundu
- headache
Coenzyme Q10 inowanikwawo mune dzimwe nhengo dzakasiyana-siyana dzinosanganisira soft and hard shell capsules, mahwendefa, uye kunyange muromo wechirwere.
Izvi zvose zvinotaurwa, chidzidzo chacho chaive chiduku (makumi mashanu chete) uye chakapedza mavhiki gumi nemaviri. Zvidzidzo zvakakura uye zvenguva refu zvekuongorora kuitika kwe coenzyme Q10 kune vanhu vane MS inofanira kuitwa.
Zvakakoshawo kunzwisisa kuti Coenzyme Q10 haina kubvumirwa neU.S. Food and Drug Administration (FDA) yekurapa chero mamiriro ekurapa, kusanganisira kuneta muna MS.
Tsvaka Nhungamiro Kubva KwaDaktari Wako
Kunyange zvazvo coenzyme Q10 iri kuwedzera uye inowanikwa pasina mushonga, inofanira kungotorwa pasi pekutarisirwa kwechiremba, kunyanya sezvo zvingasava zvakanaka kune munhu wose.
Somuenzaniso, mune vamwe vanhu, coenzyme Q10 inogona kuderedza shuga yeropa. Izvi zvingava zvinetso kune vanhu vane chirwere cheshuga avo vari kutorawo mishonga ine hutachiwana hwemashuga eropa.
Inogonawo kutaurirana nemimwe mishonga inoshandiswa neropa remishonga kana ropa rinopedza mishonga. Saka kunyange kana chiremba wako achikupa yakanaka kuti uedze coenzyme Q10, unogona kunge uchida kunyatsoongorora.
Uyewo, muyero unoshandiswa mukugadzidza ino unofanirwa kumusoro pa 500mg pazuva. Zvizhinji zvinowedzera mabhodhoro anoti haatore kudarika 200mg pazuva. Kana uchizoedza kuwedzera ichi, simbisa chirongwa chakanaka nechiremba wako. Semuenzaniso, kutora chirwere chakanyanya kudarika kunogona kuve chema-therapeutic (mune mamwe mazwi, kwete kuwedzera mukana wokukubatsira).
A Peek In the Future of Coenzyme Q10 in Multiple Sclerosis
Coenzyme Q10 haina kuongororwa zvakawanda mu multiple sclerosis, asi izvi zvingave zviri kuchinja.
Ichokwadi, chidzidzo chakabhadharwa neNational Institute of Neurological Disorders uye Stroke chiri kuongorora migumisiro yemushonga unonzi Idebenon-mishonga inogadzirwa nevanhu yakafanana ne coenzyme Q10. Ichi chidzidzo chiri kuongorora kuchengetedzwa nekubudirira kweIngbenone mukurapa vanhu vane MS-primary-progressive MS .
Chidzidzo chacho chiri kunyatsoenzanisa chiyero chekufambira mberi kweuropi atrophy (kupera kweuropi kubva pakurasikirwa kwemasero emagunha) kuvanhu vanotora Idebenone kune vanhu vanotora placebo.
Ichi chidzidzo ndechidzidzo chePekutanga I / II, saka chaiye, asi chinonakidza zvisinei-kunyanya sezvo pasina ikozvino mairi mishonga inogamuchirwa neDAA yekurapa MS-inofambira mberi.
Shoko Rinobva
Kunyange zvazvo kunyanya kushandiswa kwesayenzi kunofanirwa kuitika mukuchengeteka uye kubatsirwa kwekutora coenzyme Q10 mukurapa zviratidzo zveSMS sekuneta, kana kunyange chirwere icho pachako, ichi chidzidzo 2016 chinoshandiswa muNutritional Neuroscience chinhu chakanaka kutanga.
> Sources:
> Mezawa M et al. Nzira yakaderedzwa ye coenzyme Q10 inovandudza glycemic control muvarwere vane chirwere cheshuga chechirwere cheshuga. Biofactors . 2012 Nov-Dec; 38 (6): 416-21.
> Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 senzira yekurapa kuneta uye kuora mwoyo mune multiple sclerosis patients: A double blind randomized clinical trial. Nutriti Neurosci . 2016; 19 (3): 138-43.
> Sanoobar M et al. Coenzyme Q10 supplementation inogadzirisa zvirwere zvinoputira muvarwere vane multiple sclerosis: aviri bofu, placebo, anorongedzwa randomised clinical trial. Nutriti Neurosci. 2015 May; 18 (4): 169-76.
> University of Maryland Medical Center. (January 2015). Coenzyme Q10.
> US National Institutes of Health. (October 2016). Dhimoni Dzakaputika-Placebo-Rakatariswa Phase I / II Clinical Trial ye Idebenone muVirwere Nekutanga Kufambira Mberi Multiple Sclerosis (IPPoMS).