Rheumatologists inogona kusiyana mu folic acid supplementation
Inowanzoita kuti vanachiremba vataure ma folic acid nokuda kwevarwere vavo rheumatoid arthritis vanobatwa ne methotrexate. Folic acid inopedzwa ne methotrexate, saka inofanira kuzadzikiswa kuburikidza nekuwedzera. Folic acid inofanirwa kuchengetedza kusvibiswa kwemasero eropa nekushaya ropa. Izvo zvave zvichionekwa kuti kuderedza kushushikana kwemafuta kubva methotrexate.
Methotrexate ndiyo inonyanya kushandiswa DMARD (chirwere chinoshandisa anti-rheumatic drug) cherheumatoid arthritis nezvimwe zvinokonzera rheumatic. Methotrexate inowanikwa mumuromo uye injectable formulations. Chero nzira, methotrexate inowanzoitwa kamwe chete pavhiki (pazuva rimwechete vhiki rese).
Zvimwe Zvirongwa Zvoutano Zvinotaura Nezve Folic Acid
Pane kuchinja kwekuti vanachiremba vanopa mamiro ezuva rimwe e1 milligram ye folic acid kana chiremba chikuru kamwe pavhiki. Nhamba yakakura inowanzopiwa zuva mushure methotrexate dose. Dzimwe nguva vanachiremba vanokurudzira varwere vavo kuti vasvike mukana wezuva nezuva pazuva re methotrexate dose yavo.
I National Rheumatoid Arthritis Society muUnited States, "Methotrexate inoderedza muviri we folic acid uye nguva yakawanda yemigumisiro inogona kuderedzwa nokutora mishonga ye folic acid. Izvi zvinogona kutorwa semamiriyoni mashanu kusvika kune gumi pavhiki. kubudirira kwe methotrexate uye kunyanya rheumatologists kukurudzira kutora folic acid imwe kana mazuva maviri mushure methotrexate, uye kunyanya kusatora pazuva rimwechete se methotrexate. "
Zvirongwa zvakasiyana-siyana zvekurapa ne folic acid zvinogona kutungamirira kumibvunzo yekuti chii chakanaka. Nyanzvi yeRheumatologist Scott Zashin, purofesa wechipatimendi wechipatara paYunivhesiti yeTexas Southwestern Medical School anoti, "Ndine varwere vangu vanoitora zuva rega rega, kusanganisira zuva re methotrexate.Ndinofunga kana yakanaka-kusanganisira iyo kana kuidarika zuva ra.
Hazvina kudzidza, asi hazvigoneki kuti kana protocol inokuvadza. "
Mhedziso Kubva kuChrisrane Review
Muhurukuro pamusoro pekuongorora kweCochrane yakabudiswa munaJuly 2013, iyo yakaratidza uchapupu hunotsigira kushandiswa kwe folic acid kugadzirisa migumisiro inobatanidzwa ne methotrexate, yakarondedzerwa kuti folic acid inoshandiswa yakasiyana-vamwe vanachiremba vanopa maflic acid kuti ishandiswe nguva dzose kuburikidza nevarwere vanotora methotrexate, asi vamwe vanachiremba vanongopa chete kune varwere vane madhara kubva methotrexate. Vamwewo havatauri zvachose nokuti vanotenda folic acid inoderedza kubudirira kwe methotrexate.
Kubvunzurudzwa, kwakabva pane zvabuda kubva kumatanho matanhatu emakiriniki, yakatsigira kushandiswa kwema-dose folic acid mu rheumatoid arthritis varwere vanobatwa ne methotrexate. Folic acid supplementation yakaderedza zviratidzo zvekudya uye chiropa chinokonzera . Iyo nyanzvi yakaratidza kuti folic acid 1 milligram zuva nezuva ndiyo inowanzoshandiswa yekuwedzera kwevashandi vanonzi methotrexate.
Kudzokorora uye pashure pekugadzirisa mharidzo zvakare kwakabvunza mibvunzo pamusoro pekuti varwere vanofanira kutora folic acid upenyu hwavo hwose, uye kana kuwedzera kwemasero kunobatsira kana kunogona kukanganisa methotrexate.
Zvakagumiswa kuti chikwata-chiitiko chekusangana chichada kudzidza zvakanyanya.
The Bottom Line
Pane mitemo yakasiyana-siyana yakagamuchirwa yekutora folic acid apo inorapwa ne methotrexate, uye zvimwe zvidzidzo zvinogona kuratidzira imwe inofanirwa. Kurukurai zvakanyanya pamwe nachiremba wenyu kuti munzwisise kuti nei achisarudza mumwe kune mumwe.
Sources:
> Butler R. Methotrexate muRheumatoid Arthritis. National Rheumatoid Arthritis Society. https://www.nras.org.uk/methotrexate-in-rheumatoid-arthritis.
> Singh JA. Folic acid zvinotsigira rheumatoid arthritis varwere vachitora methotrexate: zvakanaka zvinowedzera zviri nani (muparidzi). Cochrane Database yekuongorora kwakarongeka 2013; 7: ED000063. dx.doi.org/10.1002/14651858.ED000063
> Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, et al. Folic acid uye folinic acid yekudzikisa migumisiro kune varwere vanowana methotrexate ye rheumatoid arthritis. Cochrane Database yekuongorora kwakarongeka 2013; 5: CD000951. dx.doi.org/10.1002/14651858.CD000951.pub2