Methotrexate inowanzogadziriswa kurapa rheumatoid arthritis nezvimwe zvirwere zverheumatic. Methotrexate inorondedzerwa sehosha -kuchinja anti-rheumatic drug (DMARD). Mishonga inoderedza marwadzo nekudzivirira kunobatanidza rheumatoid arthritis, kunonoka kufambira mberi kwechirwere ichi, uye kunobatsira kudzivirira kuwirirana pamwe. Paunofunga kubudirira uye kuchengeteka, chirongwa che methotrexate chiri nani kupfuura oral methotrexate?
Kuwanika
Oral methotrexate inowanika mumapiritsi maviri e 2.5 mg. Iyo inowanzo kutanga mazamu evanhu vakuru vane rheumatoid arthritis ndeye 7.5 kusvika 10 mg (3 kusvika ku4 mapiritsi) akatorwa pamwechete kamwe kamwe pavhiki. Kana zvichidiwa, chirwere chacho chinogona kuwedzera zvishoma nezvishoma kusvika 20 kusvika ku25 mg pavhiki. Chiremba wako achagadzirisa chirongwa chakakodzera kwauri.
Methotrexate injection inopiwa pasi peganda (subcutaneously). Inouya se 25 mg ne 1 milliliter kana cubic centimeter. Zvakare, chiremba wako achapa chirongwa chako chaunofanira kushandisa. Muvana vane vana rheumatoid arthritis, muyero wacho unobva pauremu hwemwana.
Ndeapi mapepa eMethotrexate Anosarudzwa?
Methotrexate injection inofungidzirwa kuti haisi nyore nevarwere vakawanda kana ichienzaniswa nemuromo methotrexate. Kutenga masiriti uye kuzvisungirira ne sindete vhiki imwe neimwe inogona kuva dambudziko. Vamwe vanhu vari kunyunyuta-phobic. Saka, sei uchinetseka apo iwe unogona kuvhara mapiritsi mashomanana?
Zvakadini kana pakanga paine musiyano pakati pejekiti ye methotrexate nemuromo methotrexate maererano nekubudirira uye njodzi yemigumisiro?
Maererano nemigumisiro inobva kuchirwere chekutanga chekuchipatara kuti iongorore zvakanyatsogadziriswa maitiro ekugadzirisa methotrexate kune varwere vane hutachiona hwehutukutu hweArthritis, yakabudiswa munaJanuary 2008 nyaya yeArthritis & Rheumatism, methotrexate injection (inonziwo subcutaneous methotrexate) inonyanya kuoma pane kutaura kutungamirirwa kwe methotrexate panguva yakaenzana, pasina kuwedzera kwemigumisiro.
Paiva nevadzidzi makumi matatu nemakumi matatu nemakumi matatu (384) vaidzidza muchidzidzo chemasvondo makumi maviri nemakumi maviri (24-week study) avo vaisarudzwa kuti vawane methotrexate injection kana mumuromo methotrexate. Vadzidzi vanenge vachidzidza, vanoti vane chirwere chepamusoro pakutanga kwekudzidza, vakagamuchira 15 mg yega yega methotrexate injection pamwe ne placebo yomuromo kana 15 mg wega pamuromo methotrexate uye placebo injection.
Kubva pane zvinyorwa zvidzidzo, vatsvakurudzi vakapedzisa kuti methotrexate injection, achishandisa miviri inogona kuwanikwa ye 15 mg / vhiki kwemaawa masere masvondo makumi maviri nemasere (kusanganisira inogona kuwedzera kuwedzerwa), inopfuura kutanga kwe methotrexate nemugwagwa. Pamasvondo makumi maviri nemana, chiyero chevarwere vane mhinduro ye ACR20 chaive chakakwirira zvikuru muboka rinogamuchira methotrexate injection (78%) kupfuura yeboka rinogamuchira muromo methotrexate (70%).
Methotrexate is Slow-Acting
Ne methotrexate kushandiswa, kuvandudzwa muzvirwere zverheumatoid arthritis kana basa rezvirwere zvinowanzoonekwa mumavhiki matatu kusvika ku6. Inogona kutora masvondo gumi nemaviri ekurapa ne methotrexate kuti zvizadzikiswe zvizere.
Migumisiro Yechiri
Rheumatoid arthritis varwere havaoni chero migumisiro yechirwere pavanotora methotrexate. Vamwe varwere vanoona zvido zviduku zvishoma zvinowedzera nekufamba kwenguva.
Nyaya yakanyanya kufanana nayo ye methotrexate ishungu.
Mimwe migumisiro inogona kusanganisira kusadya kwechiropa kushanda kushanda , zvironda mumuromo , kuputika, kurarisa, kusuruvara kwevhudzi , kushuvira kwezuva , uye kusakosha muhuwandu hwemagazi. Iko kune mikana yematambudziko emapapu zvakare.
Sources:
Methotrexate (Rheumatrex, Trexall, Otrexup, Rasuvo). American College of Rheumatology. Michael Cannon, MD. March 2015.
Kuenzaniswa kwekliniki inobudirira nekuchengetedzwa kwemukati mutsinhanisi nemutauriro wekutaura we methotrexate kune varwere vane hutachiona hwehutachiona hweArthritis. Braun et al. Arthritis & Rheumatism Volume 58, Nyaya 1, Mapeji 73-81. December 28, 2007.