Kamwe-kwevhiki rimwechete Subcutaneous Autoinjector
Rasuvo (methotrexate), single-dose autoinjector ine mishonga yemishonga methotrexate , yakagamuchirwa neU.S. Food and Drug Administration (FDA) musi waJuly 11, 2014. Rasuvo, yakagadzirwa naMedac, Pharma, Inc. iri nyore- shandisa nzira dzakasiyana-siyana kumuromo methotrexate kana kuti ye-vial-and-syringe injectable fomu.
Zviratidzo zveRasuvo
Rasuvo inogamuchirwa kuti vatungamiri vevarwere vane chirwere chakanyanya, chinoshanda che rheumatoid arthritis uye polyarticular vana vechidiki idiopathic arthritis vakange vasina kukwana kugadzirisa mushonga wekutanga wekutanga kana kuti vakanga vasina kukanganisa.
Rasuvo inoratidzwawo nekudzora zviratidzo zvinosangana nekuoma, recalcitrant, kudzivisa psoriasis kune vanhu vakuru vakakundikana kuwana mhinduro inogutsa nemamwe maitiro ekurapa. ( Cherechedza: Rasuvo haifaniri kushandiswa kurapa zvirwere zveeoplastic.)
Kutungamirirwa kweRasuvo
Rasuvo inotungamirirwa kamwe chete nevhiki semushandisi wekutengesa chete. Rasuvo inowanikwa mumatomu gumi kubva ku7,5 mg kusvika ku 30 mg (mu 2.5 mg kuwedzera). Iyo autoinjector inokonzerwa nemunhu uye inofanirwa kuiswa mumimba kana chidya. Mamwe maitiro e methotrexate anofanira kushandiswa kana kuwandisa pasi pe7,5 mg kana kupfuura 30 mg kunyoreswa-kana kana kugadziriswa pasi pe 2.5 mg kuchidiwa.
Izvo zvinotanga kumira mutezo we methotrexate ye rheumatoid arthritis ndeye 7.5 mg kamwechete kwevhiki kune injodzi yemumuromo kana inonyorera. Nokuda kweporioriasis, inowanzotangira chirwere chacho ndeye 10-25 mg kamwe chete kwevhiki kuburikidza nemuromo, zvinyorwa, zviduku, kana kushandiswa kwemukati.
Ne polyarticular vana vechidiki idiopathic arthritis, iyo inotanga kuisa inonzi 10mg / m2 kamwe chete kwevhiki (m2 yakaita mita mamita yemuviri nzvimbo).
Ndiani Asingashandisi Rasuvo?
Rheumatoid arthritis varwere vane pamuviri havafaniri kushandisa Rasuvo. Inofanirawo kudzivirirwa navanaamai vanoyamwisa, pamwe chete nevarwere vanobata: kudhakwa kana chirwere cheropa, immunodeficiency syndromes, kana preexisting ropa dyscrasias.
Varwere vane hypersensitivity vanozivikanwa kuti methotrexate vanofanirawo kudzivisa Rasuvo.
Zvinowanzovhiringidza Kuchinja
Pane zvinowanzoitika zvinosangana neRasuvo kusanganisira, kuora mwoyo, kurwadziwa mumimba, dyspepsia, chironda chemuviri kana muromo, nasopharyngitis, chirwere, chirwere chechiropa, kusavheneka, musoro, bronchitis, thrombocytopenia (low plates), alopecia, leukopenia (low white blood cell kuverenga), pancytopenia (pasi shoma yemarudzi ose emasero eropa), dutu, uye kunzwisisa kune ultraviolet chiedza. Kana uine mhinduro yakaipa, unogona kuudza iyo muiti wezvinodhaka pa 1-855-336-3322, kune FDA pa 1-800-FDA-1088, kana kuti Medwatch pane http://www.fda.gov/medwatch .
Kubatana Kwemishonga
Chiremba wako anofanira kuva nerunyorwa rwemishonga yose uye zvigadziri zvauri kutora ikozvino. Cherechedza kuti nokutora aspirin, NSAID , kana kuti corticosteroid mishonga pamwe chete neRasuvo, serum methotrexate mazinga anogona kuwedzerwa (kureva kuti, inogona kuramba iri muropa rako kwenguva refu) uye inogona kuwedzera dambudziko rekushaya chepfu.
Kutora proton pump inhibitors (kureva, Nexium kana omeprazole) neRasuvo kunogonawo kupedzera serum methotrexate mazinga uye kuwedzera kungozi yekutyisa.
Manyevero uye Kuchengetedza
Rasuvo inosanganisira Boxed Warning (iyo inonyanya kukurudzira nyevero yakabudiswa).
Mashoko akajekesa aya eBhokisied Warning ndeokuti:
- Rasuvo inofanira kungoshandiswa navanachiremba vane zivo uye ruzivo rwe antimetabolite therapy. Rasuvo inonzi folate analog metabolic inhibitor.
- Nemhaka yezvingaita zvakakomba zvinosvibisa, zvichida kuuraya, Rasuvo inofanira kurongerwa kune avo vane rheumatoid arthritis, psoriasis, kana kuti polyarticular vana vechidiki idiopathic arthritis vasina kupindura kune dzimwe mishonga.
- Methotrexate inonzi yakakonzera rufu rwekuberekwa kana kuberekwa kusina kunaka.
- Methotrexate kupera kunoderera kune avo vane utano husina kunaka, ascites, kana kuti kunyunyuta kuderera.
- Bhoora marrow kudzvinyirira, aplastic anemia, uye masimba kunyohwa zvinogona kuitika zvisingatarisirwi uye zvinogona kuuraya kana methotrexate inotorwa neNSAIDs.
- Kushandisa kwenguva refu methotrexate kunogona kukonzera hepatotoxicity, fibrosis, uye cirrhosis. Periodic chiropa test biopsy inogona kuratidzwa.
- Methotrexate-induced lung disease (semuenzaniso, yakaoma uye isingagumi mukati-kati pepneumonitis) inogona kuitika, kunyange pamitambo yakadzika.
- Diarrhea uye ulcerative stomatitis inoda kuti kurapwa ne methotrexate kuve kwakadzivirirwa kudzivirira mumimba kuora mwoyo kana kushaya zvirwere.
- Malignant lymphoma inogona kukura kunyange nehana yakanyanya methotrexate. Chirwere ichi chinofanira kuregwa kuti chione kana lymphoma ichidzoka.
- Methotrexate inogona kukurudzira "tumor lysis syndrome" kune varwere vane kukura nokukurumidza.
- Yakakura, dzimwe nguva inouraya, kugadzikana kweganda kunogona kuitika nekushandisa methotrexate.
- Zvichida kuuraya zvirwere zvinotapukira zvinogona kuitika pamwe nekushandisa methotrexate.
- Kana methotrexate inopiwa pamwe chete ne-radiotherapy, pangava nehuwandu hwehutachiona hwetachiona necrosis uye osteonecrosis .
The Bottom Line
Rasuvo inzira yakagadzirwa ye methotrexate. Rasuvo anotakura zvose zvingangova nemigumisiro yakaipa uye kunyeverwa kwebhokisi rinobatanidzwa nemamwe maitiro e methotrexate.
Sources
Rasuvo. Kunyatsorondedzera Mashoko . Revised 7/2014.
Rasuvo Inobvumirana Nhoroondo. drugs.com.