Iyo mishonga yakange yakave nemigumisiro yakavhenganiswa uye ikozvino inogadziriswa muEurope
Vatsvakurudzi vakadzidza Diacerein kuti vaone kana mishonga inogona kuderedza kufambira mberi kweasteoarthritis. Zvirwere-zvinoshandiswa zvinodhaka zvinoshandiswa kurapwa kwerheumatoid arthritis nezvimwe zvinopesana nemararthritis. Asi zvinodhaka zvinogona kugadzirisa kufambira mberi kweasteoarthritis , kunonoka kuwirirana pamwe nekuderedza mukana wekuremara, kuramba usina kudzivirirwa.
Zvinosuruvarisa, Diacerein haasati aratidzira kuti njodzi dzinodarika zvikomborero zvayo, uye zvinowanzoitwa osteoarthritis zvirwere hazvina kuderedza chirwere ichi kubva pakufambira mberi.
IUUAL Treatments Do not Slow Disease Progression
Nzira dzisiri dzisingashandisi zvinodhaka pamabvi eodheearthritis uye hip osteoarthritis , maviri emapfundo akawanda anokonzerwa newasteoarthritis, anosanganisira kuora muviri, kuedza muviri, uye kudzivisa kuita zvinhu zvinoremedza zvinowedzera kuoma kumapfundo.
Zvinodhaka uye zvinowedzera zviremba zvinoshandisa kurapa osteoarthritis zvinosanganisira kudya kwakakwana kwe vitamini D; analgesics dzakadai seTylenol ; NSAIDs (nonsteroidal anti-inflammatory drugs) yakadai se naproxen uye ibuprofen; zvinowedzera zvakadai sa glucosamine sulfate ; uye majekiseni anobatana . Dzimwe nzira dzokurapa dziriwo pakati pezvakakurumbira zvekurapa. Zvimwe kunze kwekurasikirwa nekurema, hakuna kumbove nehuchapupu hunogutsa hwokuti maitiro aya ekurapa anononoka kana kudzivirira osteoarthritis.
Zvidzidzo zveDiacerein seOsteoarthritis Disease-Modifier
Zvidzidzo zvakatsvaga kukwanisa kushandisa diacerein kuporesa osteoarthritis emabvi uye muchiuno. Diacerein chirwere chinopesana nokuputika chinoshanda nenzira yakasiyana kubva kuNSAIDS chaiyo. Diacerein inodzivirira interleukin-1, kusiyana nekudzivisa cyclooxygenase (COX) nzira iyo NSAIDs ichiita.
Mukutsvaga, varwere vanowanzogamuchira mitsara ye 50 mg ye diacerein kaviri pazuva. Muna 2006, Cochrane Collaboration yakabudisa kuongororwa kwezvidzidzo zvinomwe zvemakiriniki zvinosanganisira diacerein zvaisanganisira varwere 2 279. Izvozvo zvakagumisa kuti diacerein yaiva nemigumisiro shoma pakuvandudza marwadzo nekuderedza kufambira mberi kweasteoarthritis zvichienzaniswa nekurapwa kwakakwana neNSAIDs kana placebo. Nzira yakanyanya kufanana nayo yakabatana ne diacerein yaiva yehara.
Iko Cochrane Collaboration yakashandura kurongeka kwavo kuitika muna 2013, ichiwedzera mitsva mitatu mitsva yevadzidzi 141. Tsvakurudzo idzva yakasimbisa kuti simba reuchapupu hwekubudirira kwe diacerein hwakanga hwakaderera kusvika pakuenzanisa, uye kuderedza kurwadziwa kwakanga kusinganyanyi. Mu osteoarthritis yehudyu, pakanga pane zviduku zvishoma zvekuderedza nzvimbo yakabatanidzwa kuderedza, asi zvingangove zvisingaitiki kuchipatara. Pane huwandu hwe24% hwekuwedzera mararamiro semagumisiro ekushandiswa kwe diacerein.
European Medicines Agency Inopa Zvipingamupinyi
Musi waMarch 19, 2014, Gwaro Rokugadzirisa Kwekugamuchirwa Kwemagariro uye Nzira Dzakasarudzwa - Vanhu (CMDh) vanobvumirwa kurambidza diacerein muEuropean Union. Ichisarudzo chakazosimbiswa pamutemo musi waSept 4, 2014. Boka rinotarisa chisarudzo chazvo pamusoro pengozi yevarwere vanoita zvirwere zvakanyanya uye zvirwere zvechiropa nekuda kwechirwere.
Muchidimbu, boka racho rakasarudza kuti dambudziko re diacerein rakapfuura zvaro.
Pane Ongororo Dzakawanda Diacerein Inodiwa Here?
Nyanzvi yeRheumatologist Dr. Scott J. Zashin yakurukura diacerein sezvinogona kurapwa kweasteoarthritis. "Panguva ino, hapana humwe uchapupu huri pachena hwokuti diacerein inobereka migumisiro inokosha sechirwere chinoshandura zvirwere chepa osteoarthritis," akadaro. "Chimwe chidzidzo chinodiwa kuti tive nekuchengetedza kwenguva pfupi uye kwenguva refu uye kubudirira kwe diacerein ye osteoarthritis."
Mushonga hauwanikwi muUnited States, European Union, Canada, Britain, kana Australia. Inogona kuwanika munyika dzakasarudzwa, zvichienderana nekuwedzera mitemo.
Chisarudzo cha2014 cheEuropean Union yekudzivirira mishonga inoratidza kuti zvinogona kuitika migumisiro yezvinodhaka zvinotambudza kupfuura chero ipi zvayo inogona kubatsira.
Sources:
Fidelix TS, Soares BG, Trevisani VF. "Diacerein yewasteoarthritis." Cochrane Database Syst Rev. 2006 Jan 25; (1): CD005117.
Fidelix TS, Macedo CR, Maxwell LJ, Fernandes Moça Trevisani V. "Diacerein for osteoarthritis." Cochrane Database Syst Rev. 2014 Feb 10; 2: CD005117. doi: 10.1002 / 14651858.CD005117.pub3.